Thursday, July 3, 2025 7/3/2025

PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT

Award Number: R01ES009815
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/1999
PERIOD OF PERFORMANCE END DATE: 12/31/2014

Group Awards By:

View Award Description

PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT - DESCRIPTION (provided by principal investigator): Owing to a legacy of industrial pollution throughout the 20th Century, families and children in the in the United States are exposed to mixtures of environmental contaminants; one of the most significant contaminants is polychlorinated biphenyls (PCBS). PCBs demonstrate multiple forms of neurotoxicity, most notably with regard to dopamine (Mariussen & Fonnum, 2006) and white matter development (Sharlin et al. 2006; Preliminary Studies). This investigative team has shown a link between exposure to PCBs and impulsive behavior, or more specifically, impaired response inhibition (Stewart et al. 2003, 2005, 2006). This highly circumscribed behavioral deficit, characterized by an impaired ability to withhold responses, is associated with a rich brain imaging literature that implicates a number of frontal and fronto-striatal structures in its regulation. The importance of the link between response inhibition and brain function in this cohort is underscored by the finding of significant reductions in white matter throughout the cerebral cortex, especially the frontal cortex, in our PCB-exposed children. We intend to investigate whether PCB exposure and impaired response inhibition is related to impaired activation of the prefrontal cortex (inferior) and if those activational changes are related to reductions in white matter integrity in frontostriatal tracts. The proposed study will capitalize on an 18 year longitudinal study of child development, in combination with state-of-the-art neuroimaging approaches at the Rochester Center for Brain Imaging (RCBI). The Specific Aims are: AIM #1) To test the hypothesis that altered activation of the prefrontal cortex (PFC) underlies the PCB-related deficits in impulse control (response inhibition). AIM #2) To test the hypothesis that frontostriatal connectivity is reduced in PCB exposed children. PUBLIC HEALTH RELEVANCE: There is reasonable evidence from research studies that indicate that prenatal exposure to PCBs produces impairments in cognitive and behavioral development in children. The Oswego Project represents one of the few major, longitudinal studies in the United States designed to assess the effects of exposure to low levels of PCBs on child development. The stable nature of the cohort, the 16 years of experience the principal investigators have with these cohorts, the well-established testing protocols, and the extensive database of exposure, outcome and potentially confounding/mediating variables permit rigorous assessment of the impact of prenatal PCB exposure in the teen years.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $324,551 )
2013	2013	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	001	12	7/17/2013	NON-COMPETING CONTINUATION	$26,494
2013	2013	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	000	12	12/20/2012	NON-COMPETING CONTINUATION	$298,057
														Subtotal = $324,551

Issue Date FY: 2012 ( Subtotal = $358,377 )
2012	2012	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	000	11	1/10/2012	NON-COMPETING CONTINUATION	$329,035
2012	2012	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	001	11	3/15/2012	NON-COMPETING CONTINUATION	$29,342
														Subtotal = $358,377

Issue Date FY: 2011 ( Subtotal = $358,377 )
2011	2011	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	001	10	6/9/2011	NON-COMPETING CONTINUATION	$22,397
2011	2011	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	000	10	12/20/2010	NON-COMPETING CONTINUATION	$335,980
														Subtotal = $358,377

Issue Date FY: 2010 ( Subtotal = $364,693 )
2010	2010	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	001	9	2/8/2010	COMPETING CONTINUATION	$364,693
2010	2007	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	000	8	2/4/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $364,693

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	000	8	6/10/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $451,275 )
2007	2007	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Environmental Health	000	8	8/3/2007	NON-COMPETING CONTINUATION	$451,275
														Subtotal = $451,275

Issue Date FY: 2006 ( Subtotal = $210,999 )
2006	2006	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	7	8/11/2006	NON-COMPETING CONTINUATION	$210,999
														Subtotal = $210,999

Issue Date FY: 2005 ( Subtotal = $213,263 )
2005	2005	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	6	9/15/2005	COMPETING CONTINUATION	$213,263
														Subtotal = $213,263

Issue Date FY: 2003 ( Subtotal = $399,978 )
2003	2003	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	5	8/11/2003	NON-COMPETING CONTINUATION	$399,978
														Subtotal = $399,978

Issue Date FY: 2002 ( Subtotal = $386,235 )
2002	2002	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	4	7/26/2002	NON-COMPETING CONTINUATION	$386,235
														Subtotal = $386,235

Issue Date FY: 2001 ( Subtotal = $373,446 )
2001	2001	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	3	8/6/2001	NON-COMPETING CONTINUATION	$373,446
														Subtotal = $373,446

Issue Date FY: 2000 ( Subtotal = $360,179 )
2000	2000	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	2	8/21/2000	NON-COMPETING CONTINUATION	$360,179
														Subtotal = $360,179

Issue Date FY: 1999 ( Subtotal = $361,122 )
1999	1999	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biometry and Risk Estimation_Health Risks from Environmental Exposures	000	1	9/23/1999	NEW	$361,122
														Subtotal = $361,122

Grand Total All Awards = $4,162,495

Top

All Categories

About

Search

Reports

Data Submission

Award Information

PRENATAL PCB EXPOSURE AND COGNITIVE DEVELOPMENT

Award Number: R01ES009815

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/1999

PERIOD OF PERFORMANCE END DATE: 12/31/2014

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer