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Imaging Goggles for Fluorescence-Guided Surgery

Award Number: R01EB030987
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Imaging Goggles for Fluorescence-Guided Surgery - Interest in the use of optical imaging instruments in medical interventions stems from their ease of use, rapid adaptation to clinical needs, portability, real-time feedback, and relatively low cost. Of particular interest is the role of optical imaging in oncology. Surgery is the primary curative method for solid tumors confined to the tissue of origin with the goal of completely removing both the tumor mass and microscopic lesions. Unfortunately, the irregular growth pattern and infiltrations into surrounding healthy tissue prevent complete removal in many cases, resulting in positive surgical margins (PSMs). PSMs are prevalent in oncologic surgery, increasing cancer recurrence rates and often necessitates a second surgery to improve disease-specific survival. While PSM occurrence is significant in advanced clinical centers, the situation is worse in many rural hospitals and resource- limited areas due to limited histology infrastructure and workforce needed for margin assessment. Thus there is an urgent need for an intraoperative imaging system to visualize cancer, guide tumor removal, and determine margin positivity in the operating room (OR) in low and high resource settings alike. Handheld fluorescence imaging systems have been developed to aid cancer resection. Still, they suffer from several limitations, including a significant footprint in the OR and the inability of the operating surgeon to directly control the imaging device while performing surgery. To address these shortcomings, we developed a head- mounted display device (HMD) cancer imaging system for real-time intraoperative fluorescence-guided surgery (FGS). The system HMD captures near-infrared (NIR) fluorescence and color images from the surgical bed and displays accurately aligned color-NIR images in real-time, enabling FGS without disrupting surgical workflow. The HMD has a small footprint, is intuitive to use, and is amenable for widespread use, including non-cancer applications such as imaging of peripheral blood flow. Preliminary testing of the HMD system in human cancer patients identified some areas for improvement that will accelerate the eventual clinical adoption of the system worldwide. Addressing these needs requires expertise in packaging software development for medical devices with DICOM image format and user interface development using human factors engineering. We have teamed up with a company that has both expertise and experience in developing augmented reality/mixed reality (AR/VR) software combined with deep machine learning in wearable devices on this project. Together, we will optimize the system performance and ergonomics using human factors engineering. The collaborative project will (1) develop and validate an automated fluorescence thresholding algorithm for tumor delineation; (2) develop and validate automated registration of augmented reality in the system; and (3) develop and evaluate clinical software to improve user experience. At the completion of this project, we expect to develop and validate a clinic-ready, user-friendly HMD system with a small hardware footprint, enabling seamless integration with surgical workflow to enhance clinical adoption. The system will increase the rates and decrease the time of successful tumor resection. Anticipated low cost and ease of use will expand adoption in low and high resource settings worldwide. This objective approach to cancer surgery will reduce the incidence of PSMs and improve treatment outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	12/8/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $483,907 )
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	6/7/2024	NON-COMPETING CONTINUATION	$39,504
2024	2024	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	12/22/2023	NON-COMPETING CONTINUATION	$444,403
														Subtotal = $483,907

Issue Date FY: 2023 ( Subtotal = $509,078 )
2023	2023	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	1/27/2023	NON-COMPETING CONTINUATION	$509,078
														Subtotal = $509,078

Issue Date FY: 2022 ( Subtotal = $585,022 )
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	2	5/31/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$585,022
2022	2022	UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER, THE	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	2	8/3/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$306,097
2022	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	1	8/3/2022	NEW	-$306,097
2022	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	5/27/2022	NEW	$0
														Subtotal = $585,022

Issue Date FY: 2021 ( Subtotal = $564,129 )
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/1/2021	NEW	$564,129
2021	2021	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	1	5/25/2021	NEW	$0
														Subtotal = $564,129

Grand Total All Awards = $2,142,136

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Imaging Goggles for Fluorescence-Guided Surgery

Award Number: R01EB030987

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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