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Genetic, Social, and Developmental Epidemiology of Drug Use Disorders

Award Number: R01DA030005
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2010
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Genetic, Social, and Developmental Epidemiology of Drug Use Disorders - Program Director/Principal Investigator: Kendler, Kenneth S This second competitive renewal seeks to continue our innovative and productive research program which seeks to understand the etiology of drug use disorders (DUD) utilizing data available on the entire population of Sweden of unparalleled completeness and depth. We have eight specific aims: i) to use a newly developed genetic risk score for DUD for the entire Swedish population to explore boundaries of the DUD phenotype, model gene x environment interactions and clarify origins of DUD-related comorbidities; ii) to understand the impact of social roles/relationships (e.g., marriage, divorce, parenthood) on risk and resilience for DUD; iii) to explore the etiology of opiate use disorder (OUD) by comparing the social, familial and genetic risk factors OUD and non-opiate DUD, by clarifying the etiologic role of opiate prescriptions in OUD development and to identify clinically meaningful subtypes of OUD, especially an iatrogenic form; iv) to investigate the impact of institutional settings on subsequent DUD, focusing on military service and incarceration; v) to evaluate the impact of synthetically constructed populations compared to actual Swedish populations in the evaluation of DUD and OUD utilizing FRED (A Framework for Reconstructing Epidemiological Dynamics) developed by our collaborators at the Public Health Dynamics Laboratory (PHDL) at University of Pittsburgh; vi) to improve our contagion models for the transmission of DUD by taking advantage of new data available in Swedish registries on high school attendance, college attendance and workplace, improved Geographic Information Systems and FRED; vii) to explore the association between stressful and traumatic events including COVID-19 exposure severity and stress-related disorders (e.g., posttraumatic stress disorder [PTSD]) with DUD onset and recurrence and examine moderators of impact of both exposures and stress-related disorders on DUD and viii) using a calibrated, detailed version of the Swedish population in FRED, to evaluate the predicted impact of a range of mitigation strategies, based on the relationships defined by our earlier work and new findings from the above aims. We will, for many of these aims, attempt to clarify the causal nature of the observed associations using statistical and natural experimental methods. We will use comprehensive data from multiple nationwide data sources in Sweden on 11.8 million men and women to accomplish these goals. Applying the deep expertise of our research groups at Virginia Commonwealth, PHDL and Lund University in drug abuse research, social and genetic epidemiology, causal inference and epidemiological model development to a uniquely powerful sample, we expect this study to have important implications for DUD research, prevention and policy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	14	12/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $589,808 )
2024	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	14	4/30/2024	NON-COMPETING CONTINUATION	$58,981
2024	2024	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	14	1/11/2024	NON-COMPETING CONTINUATION	$530,827
														Subtotal = $589,808

Issue Date FY: 2023 ( Subtotal = $590,694 )
2023	2023	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	13	1/11/2023	NON-COMPETING CONTINUATION	$59,069
2023	2023	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	13	12/28/2022	NON-COMPETING CONTINUATION	$531,625
														Subtotal = $590,694

Issue Date FY: 2022 ( Subtotal = $590,270 )
2022	2022	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	003	12	3/30/2022	NON-COMPETING CONTINUATION	$59,026
2022	2022	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	002	12	12/16/2021	NON-COMPETING CONTINUATION	$531,244
2022	2021	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	005	11	6/3/2022	COMPETING CONTINUATION	$3,793
2022	2021	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	11	11/9/2021	COMPETING CONTINUATION	$293,369
2022	2020	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	10	11/9/2021	NON-COMPETING CONTINUATION	-$293,369
2022	2020	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	004	10	6/3/2022	NON-COMPETING CONTINUATION	-$3,793
														Subtotal = $590,270

Issue Date FY: 2021 ( Subtotal = $627,950 )
2021	2021	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	11	3/10/2021	COMPETING CONTINUATION	$627,950
2021	2020	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	10	3/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $627,950

Issue Date FY: 2020 ( Subtotal = $570,518 )
2020	2020	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	10	1/16/2020	NON-COMPETING CONTINUATION	$570,518
														Subtotal = $570,518

Issue Date FY: 2019 ( Subtotal = $560,441 )
2019	2019	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	9	1/14/2019	NON-COMPETING CONTINUATION	$462,090
2019	2019	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	9	6/18/2019	SUPPLEMENT FOR EXPANSION	$98,351
														Subtotal = $560,441

Issue Date FY: 2018 ( Subtotal = $468,027 )
2018	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	8	1/19/2018	NON-COMPETING CONTINUATION	$421,224
2018	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	8	4/26/2018	NON-COMPETING CONTINUATION	$46,803
														Subtotal = $468,027

Issue Date FY: 2017 ( Subtotal = $474,662 )
2017	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	001	7	5/22/2017	NON-COMPETING CONTINUATION	$47,467
2017	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	7	1/9/2017	NON-COMPETING CONTINUATION	$427,195
														Subtotal = $474,662

Issue Date FY: 2016 ( Subtotal = $476,992 )
2016	2016	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Drug Use and Addiction Research Programs	000	6	3/1/2016	COMPETING CONTINUATION	$476,992
														Subtotal = $476,992

Issue Date FY: 2014 ( Subtotal = $501,604 )
2014	2014	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	000	5	12/26/2013	NON-COMPETING CONTINUATION	$451,443
2014	2014	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	001	5	2/20/2014	NON-COMPETING CONTINUATION	$50,161
														Subtotal = $501,604

Issue Date FY: 2013 ( Subtotal = $494,632 )
2013	2013	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	001	4	5/21/2013	EXTENSION WITH OR WITHOUT FUNDS	$30,915
2013	2013	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	000	4	4/4/2013	EXTENSION WITH OR WITHOUT FUNDS	$463,717
														Subtotal = $494,632

Issue Date FY: 2012 ( Subtotal = $526,694 )
2012	2012	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	000	3	1/31/2012	NON-COMPETING CONTINUATION	$526,694
														Subtotal = $526,694

Issue Date FY: 2011 ( Subtotal = $541,644 )
2011	2011	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	002	2	6/28/2011	NON-COMPETING CONTINUATION	$39,089
2011	2011	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	000	2	4/26/2011	NON-COMPETING CONTINUATION	$502,555
2011	2010	UNIVERSITY OF LUND	BOX 112	LUND		00000		SWE	Drug Use and Addiction Research Programs	001	1	6/28/2011	NEW	$0
														Subtotal = $541,644

Issue Date FY: 2010 ( Subtotal = $555,467 )
2010	2010	UNIVERSITY OF LUND	BOX 112	LUND				SWE	Drug Use and Addiction Research Programs	000	1	3/12/2010	NEW	$555,467
														Subtotal = $555,467

Grand Total All Awards = $7,569,403

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Genetic, Social, and Developmental Epidemiology of Drug Use Disorders

Award Number: R01DA030005

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2010

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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