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Low-Dose Exposure to Ionizing Radiation in Adulthood and Subsequent Cancer

Award Number: R01CA242852
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Low-Dose Exposure to Ionizing Radiation in Adulthood and Subsequent Cancer - ABSTRACT Since the 1980s, the US public’s exposure to ionizing radiation has increased, largely due to increasing radiation from diagnostic medical procedures such as computed tomography (CT) exams. The doses from such procedures are typically low but may be repeated over time and increase in frequency in later life. Quantitative estimates of radiation-associated cancer risk are primarily derived from the study of Japanese atomic bomb survivors. Questions have been raised about the appropriateness of using a study of atomic bomb survivors as the basis for contemporary estimates of radiation risk from protracted, low dose exposures. The parent study for this proposal assembled an international cohort of 308,000 radiation dosimeter-monitored workers from some of the world’s most informative cohorts in the United Kingdom, France, and USA, in a project called INWORKS. Here, we propose a major update that extends follow-up of each national cohort by at least 10 years, anticipated to yield more than a fifty percent increase in the number of cancer cases in the pooled analysis and support an innovative set of analyses to directly address questions relevant to radiation protection for low dose exposure to ionizing radiation in adulthood: 1) radiation-associated risks for solid cancer and leukemia; 2) cancer site-specific radiation risks; 3) cumulative absolute excess cancer risk estimates and their coherence with the risk models currently used to inform radiation protection and decision- making; 4) modification of site-specific excess relative rates (per unit dose) with time since exposure and age-at-exposure; and, 5) combined analyses of information from INWORKS and the Japanese atomic bomb survivor data to yield superior estimates of low dose radiation- cancer mortality associations. We leverage state-of-the-art G-estimation methods for cumulative risk estimation, Bayesian methods for data smoothing, and applied decision theory to guide policy-relevant summarizations of these empirical data. The study will provide a direct assessment of radiation risk following protracted, low dose radiation exposures in adulthood; and the findings will complement evidence regarding radiation risks derived from the study of Japanese atomic bomb survivors. The proposed study builds logically upon results of the highly successful parent study and is likely to exert a sustained influence on the field and make a major contribution to national and international radiation protection recommendations. Research outputs will be disseminated via peer-reviewed journals, presentations, a project website, and engagement with radiation protection organizations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $368,807 )
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Cancer Cause and Prevention Research	001	5	5/19/2026	COMPETING CONTINUATION	$379,407
2026	2022	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Cancer Cause and Prevention Research	000	4	1/14/2026	NON-COMPETING CONTINUATION	-$10,600
														Subtotal = $368,807

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Cancer Cause and Prevention Research	000	4	9/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $351,956 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Cancer Cause and Prevention Research	003	4	8/23/2022	NON-COMPETING CONTINUATION	$351,956
2022	2021	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Cancer Cause and Prevention Research	002	3	1/13/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$391,046
2022	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	001	2	1/13/2022	NON-COMPETING CONTINUATION	-$347,451
2022	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	1	1/13/2022	NEW	-$43,595
														Subtotal = $351,956

Issue Date FY: 2021 ( Subtotal = $359,138 )
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Cancer Cause and Prevention Research	001	3	9/16/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$359,138
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	2	9/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $359,138

Issue Date FY: 2020 ( Subtotal = $347,451 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	001	2	8/14/2020	NON-COMPETING CONTINUATION	$347,451
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	1	11/7/2019	NEW	$0
														Subtotal = $347,451

Issue Date FY: 2019 ( Subtotal = $359,555 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Cause and Prevention Research	000	1	9/20/2019	NEW	$359,555
														Subtotal = $359,555

Grand Total All Awards = $1,786,907

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Low-Dose Exposure to Ionizing Radiation in Adulthood and Subsequent Cancer

Award Number: R01CA242852

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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