Friday, March 14, 2025 3/14/2025

TGFbeta-regulated epithelial-mesenchymal transition (EMT)

Award Number: R01CA154663
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

Abstract Aggressive tumors that are metastatic and intrinsically resistant to conventional therapies represent a critical issue mediating the morbidity and mortality of most, if not all tumors, including breast cancer. It is postulated that targeting the epithelial-mesenchymal transition (EMT) and the ensuing formation of cancer stem cells (CSCs) is likely to represent a means of reducing the rate at which primary breast cancers spawn metastatic derivatives. In the context of cancer, cells having undergone an EMT have enhanced tumor-initiating ability, are capable of generating mammospheres, exhibit cell-surface markers and gene expression profiles similar to both normal mammary (MaSC) and breast cancer (BCSC) stem cells and become more resistant to chemotherapeutics. We have recently demonstrated a role for TGFβ-induced EMT in the formation of tumor initiating cells (TICs), through a signaling pathway involving the RNA binding protein hnRNP E1 (E1). Herein, our data demonstrates that this TGFβ/E1/ signaling pathway leads to the induction of an embryonic lncRNA known as Platr18 (pluripotent associated transcript 18). We show that this lncRNA is not expressed in normal epithelium or other adult somatic tissues but is highly induced by the TGFβ/E1 axis and in cells having undergone an EMT or during cancer progression. The scientific premise of the proposal is that the TGFβ- mediated EMT program induces the generation of TICs and tumor progression through TGFβ/E1 signaling and reactivation of silenced Platr18. Its goals are to delineate the molecular mechanism(s) of Platr18 function and determine its role in modulating T-cell mediated immunity through VSIG-3 & tumor innervation through Sema4F.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $336,353 )
2025	2025	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	15	12/9/2024	NON-COMPETING CONTINUATION	$336,353
														Subtotal = $336,353

Issue Date FY: 2024 ( Subtotal = $355,038 )
2024	2024	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	001	14	4/16/2024	NON-COMPETING CONTINUATION	$18,685
2024	2024	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	14	1/11/2024	NON-COMPETING CONTINUATION	$336,353
														Subtotal = $355,038

Issue Date FY: 2023 ( Subtotal = $373,725 )
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	13	12/20/2022	NON-COMPETING CONTINUATION	$336,353
2023	2023	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	001	13	3/15/2023	NON-COMPETING CONTINUATION	$37,372
														Subtotal = $373,725

Issue Date FY: 2022 ( Subtotal = $373,107 )
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	12	1/7/2022	COMPETING CONTINUATION	$373,107
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	002	12	4/29/2022	COMPETING CONTINUATION	$90,546
2022	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	001	11	4/29/2022	NON-COMPETING CONTINUATION	-$90,546
														Subtotal = $373,107

Issue Date FY: 2021 ( Subtotal = $355,063 )
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	11	11/20/2020	NON-COMPETING CONTINUATION	$337,309
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	001	11	1/29/2021	NON-COMPETING CONTINUATION	$17,754
														Subtotal = $355,063

Issue Date FY: 2020 ( Subtotal = $355,063 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	001	10	1/17/2020	NON-COMPETING CONTINUATION	$35,507
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	10	12/12/2019	NON-COMPETING CONTINUATION	$319,556
														Subtotal = $355,063

Issue Date FY: 2019 ( Subtotal = $344,411 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	9	12/13/2018	NON-COMPETING CONTINUATION	$344,411
														Subtotal = $344,411

Issue Date FY: 2018 ( Subtotal = $355,063 )
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	001	8	5/23/2018	NON-COMPETING CONTINUATION	$35,507
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	8	12/14/2017	NON-COMPETING CONTINUATION	$319,556
														Subtotal = $355,063

Issue Date FY: 2017 ( Subtotal = $355,063 )
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	001	7	1/24/2017	COMPETING CONTINUATION	$0
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	000	7	11/23/2016	COMPETING CONTINUATION	$355,063
2017	2017	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	003	7	5/8/2017	COMPETING CONTINUATION	$2
2017	2015	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Cancer Biology Research	002	6	5/8/2017	NON-COMPETING CONTINUATION	-$2
														Subtotal = $355,063

Issue Date FY: 2015 ( Subtotal = $306,063 )
2015	2015	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	000	6	11/18/2014	NON-COMPETING CONTINUATION	$275,456
2015	2015	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	001	6	1/27/2015	NON-COMPETING CONTINUATION	$30,607
														Subtotal = $306,063

Issue Date FY: 2014 ( Subtotal = $296,881 )
2014	2014	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	001	5	7/18/2014	NON-COMPETING CONTINUATION	$21,424
2014	2014	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	000	5	12/10/2013	NON-COMPETING CONTINUATION	$275,457
														Subtotal = $296,881

Issue Date FY: 2013 ( Subtotal = $287,699 )
2013	2013	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	001	4	6/7/2013	NON-COMPETING CONTINUATION	$134,668
2013	2013	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	000	4	12/6/2012	NON-COMPETING CONTINUATION	$153,031
														Subtotal = $287,699

Issue Date FY: 2012 ( Subtotal = $306,063 )
2012	2012	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	000	3	12/30/2011	NON-COMPETING CONTINUATION	$275,457
2012	2012	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	001	3	4/20/2012	NON-COMPETING CONTINUATION	$30,606
														Subtotal = $306,063

Issue Date FY: 2011 ( Subtotal = $316,482 )
2011	2011	CWRU-CLEVELAND CLINIC LERNER COLLEGE	9500 EUCLID AVENUE	CLEVELAND	OH	44195	CUYAHOGA	USA	Cancer Biology Research	000	1	12/14/2010	NEW	$325,775
2011	2011	CWRU-CLEVELAND CLINIC LERNER COLLEGE	9500 EUCLID AVENUE	CLEVELAND	OH	44195	CUYAHOGA	USA	Cancer Biology Research	002	1	9/12/2011	NEW	-$316,482
2011	2011	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29403	CHARLESTON	USA	Cancer Biology Research	001	2	9/9/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$195,800
2011	2011	CWRU-CLEVELAND CLINIC LERNER COLLEGE	9500 EUCLID AVENUE	CLEVELAND	OH	44195	CUYAHOGA	USA	Cancer Biology Research	003	1	9/23/2011	NEW	$111,389
														Subtotal = $316,482

Grand Total All Awards = $4,716,074

Top

All Categories

About

Search

Reports

Data Submission

Award Information

TGFbeta-regulated epithelial-mesenchymal transition (EMT)

Award Number: R01CA154663

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer