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Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes

Award Number: R01AR055563
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The overall goal of this project is to prevent risk of second anterior cruciate ligament (ACL) injury in vulnerable populations, which consist of young, active men, women, girls and boys. Specifically, we propose to 1) stratify patients into risk groups for second ACL injury, 2) determine the effects of differential treatment on biomechanical measures of ACL injury risk and return to sport readiness after reconstruction (ACLR). Additionally, we will begin the development of a clinical algorithm that will classify patient risk for second ACL injury to facilitate the translation of findings from the laboratory into the clinic. Differential treatment will include a home only program, a standard clinical rehabilitation program, and a novel targeted neuromuscular training program designed to augment core and hip strength as well as promote optimum, low risk movement strategies in both lower extremities. Highly active men and women between the ages of 14 ≥ 24 years who have sustained an acute, isolated primary ACL injury will be recruited for study participation. As patients enter their final phase of rehabilitation after surgery they will undergo testing that includes self-reported function, performance of drop jumps, hop testing, strength assessment, and balance assessment. After testing, patients will be randomized into one of the three intervention groups for a six-week, twelve-session training program. After completion of training the patients will repeat the same battery of tests. To determine relative risk for second ACL injury, cluster-analysis statistical testing will be performed. Differences between risk-groups will be validated using the frontal plane hip and knee motions, which will be used as surrogates for ACL injury. Repeated measures ANOVA testing will be conducted to identify differences before and after testing to determine the effectiveness of each intervention program on clinical performance and biomechanical measures. Results from this proposed work will allow us to prospectively identify high risk patients who are the most appropriate recipients of enhanced treatment, including targeted neuromuscular training, which may reduce second ACL risk. Patients with lower-risk for second ACL injury may achieve optimum benefits from less intensive intervention. Thus, differential interventions may reduce the risk of a subsequent injury, enhance the quality of life for a significant cohort of young adults, and yield a more efficacious delivery of health care resources after ACLR.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$10,418 )
2025	2022	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	10	11/4/2024	NON-COMPETING CONTINUATION	-$10,418
														Subtotal = -$10,418

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	10	6/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $692,585 )
2022	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	10	7/12/2022	NON-COMPETING CONTINUATION	$692,585
														Subtotal = $692,585

Issue Date FY: 2021 ( Subtotal = $674,940 )
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	9	7/2/2021	NON-COMPETING CONTINUATION	$674,940
2021	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	7/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $674,940

Issue Date FY: 2020 ( Subtotal = $696,334 )
2020	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	8	6/15/2020	NON-COMPETING CONTINUATION	$696,334
														Subtotal = $696,334

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	7	7/11/2019	NON-COMPETING CONTINUATION	$0
2019	2018	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	7	5/22/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $645,051 )
2018	2018	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	7	7/17/2018	NON-COMPETING CONTINUATION	$645,051
														Subtotal = $645,051

Issue Date FY: 2017 ( Subtotal = $566,618 )
2017	2017	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	6	8/28/2017	COMPETING CONTINUATION	$566,618
														Subtotal = $566,618

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2012	OHIO STATE UNIVERSITY	1800 CANNON DR/700 LINCOLN TOW	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	9/9/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $665,441 )
2012	2012	OHIO STATE UNIVERSITY	1800 CANNON DR/700 LINCOLN TOW	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	8/9/2012	NON-COMPETING CONTINUATION	$665,441
														Subtotal = $665,441

Issue Date FY: 2011 ( Subtotal = $2 )
2011	2011	OHIO STATE UNIVERSITY	1800 CANNON DR/700 LINCOLN TOW	COLUMBUS	OH	43210	FRANKLIN	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	7/29/2011	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$2
														Subtotal = $2

Issue Date FY: 2010 ( Subtotal = $683,350 )
2010	2010	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	8/5/2010	NON-COMPETING CONTINUATION	$659,123
2010	2010	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	3/15/2010	SUPPLEMENT FOR EXPANSION	$24,227
														Subtotal = $683,350

Issue Date FY: 2009 ( Subtotal = $647,629 )
2009	2009	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/31/2009	NON-COMPETING CONTINUATION	$647,629
														Subtotal = $647,629

Issue Date FY: 2008 ( Subtotal = $626,933 )
2008	2008	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/28/2008	NEW	$626,933
														Subtotal = $626,933

Grand Total All Awards = $5,888,465

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Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes

Award Number: R01AR055563

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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