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 | Issue Date FY: 2026 ( Subtotal = $372,103 ) |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG076636 | Advancing MR elastography to map mechanical signatures of key AD/ADRD processes | 000 | 4 | NIH | 11/26/2025 | $397,775 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01CA271410 | Mayo Clinic Center for Clinical Proteomics | 000 | 4 | NIH | 11/24/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01FD007842 | Development of the brain penetrant ATM inhibitor WSD0628 in combination with radiation for recurrent high grade glioma | 000 | 2 | FDA | 11/20/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01DK108288 | The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer | 000 | 10 | NIH | 11/26/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01DK108288 | The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer | 000 | 10 | NIH | 11/26/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA237398 | Role of Nuclear Pore-Regulated Mechanisms in Prostate Cancer Aggressiveness | 000 | 6 | NIH | 11/20/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA225996 | BAK Autoactivation in Hematological Malignancies | 000 | 5 | NIH | 11/26/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA242023 | Regulation of pten tumor suppressive functions by C-tail phosphorylation. | 000 | 5 | NIH | 11/19/2025 | $0 |
| | 2026 | 2023 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21NS130297 | Harnessing the latent heat of saline evaporation for safe and effective endovascular therapeutic organ cooling | 000 | 1 | NIH | 11/25/2025 | -$25,672 |
| | 2026 | 2023 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01MH122258 | CRCNS: Processing speed in the human connectome across the lifespan | 000 | 5 | NIH | 11/24/2025 | $0 |
|
| Issue Date FY: 2025 ( Subtotal = $290,064,443 ) (Continued on the next page) |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01EB036541 | A Dynamic Patient Data Library and Virtual Imaging Trial Platform for Training and Evaluating AI-based Algorithms in CT Imaging | 000 | 1 | NIH | 7/23/2025 | $641,063 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R33AT012185 | MRI-based quantitative characterization of impaired myofascial interface properties in myofascial pain syndrome | 000 | 2 | NIH | 8/12/2025 | $1,578,672 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01CA271410 | Mayo Clinic Center for Clinical Proteomics | 001 | 4 | NIH | 7/29/2025 | $1,115,210 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG050603 | Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal study | 001 | 10 | NIH | 6/10/2025 | $63,472 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG050603 | Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal study | 000 | 10 | NIH | 3/18/2025 | $714,049 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03OD039975 | Rare variant analysis integrating large public DNA sequencing controls and gene expression data for discovering novel predisposition genes of orofacial clefts | 000 | 1 | NIH | 6/10/2025 | $320,799 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081584 | Biophysically inspired mechanical biomarkers of normal pressure hydrocephalus | 001 | 2 | NIH | 6/10/2025 | $32,280 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081584 | Biophysically inspired mechanical biomarkers of normal pressure hydrocephalus | 000 | 2 | NIH | 3/20/2025 | $363,150 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | F32DK145067 | The role of sympathetic signaling in inflammation-induced colon dysfunction and recovery | 001 | 1 | NIH | 7/31/2025 | $0 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | F32DK145067 | The role of sympathetic signaling in inflammation-induced colon dysfunction and recovery | 000 | 1 | NIH | 7/31/2025 | $75,520 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03OD039975 | Rare variant analysis integrating large public DNA sequencing controls and gene expression data for discovering novel predisposition genes of orofacial clefts | 000 | 1 | NIH | 6/10/2025 | $1 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL164416 | Targeting Immune-Responsive Gene 1 (Irg1) and Itaconate for Cardioprotection of the Donor Heart for Transplantation | 002 | 4 | NIH | 7/29/2025 | $647,639 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01LM014760 | Virtual World-based Cardiac Rehabilitation to Promote Data-Powered Cardiovascular Health Among Cardiac Patients: A Multicenter Randomized Clinical Trial | 001 | 1 | NIH | 9/22/2025 | $0 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR084242 | Leveraging Large Language Models to Automate and Improve Accuracy of Medical Registry Curation | 000 | 1 | NIH | 9/11/2025 | $377,273 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01LM014760 | Virtual World-based Cardiac Rehabilitation to Promote Data-Powered Cardiovascular Health Among Cardiac Patients: A Multicenter Randomized Clinical Trial | 000 | 1 | NIH | 9/9/2025 | $390,852 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UH3NS132128 | Hybrid approach for comprehensive mutation detection in a cell | 000 | 3 | NIH | 9/10/2025 | $562,405 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R13CA306357 | Africa HepatoPancreatoBiliary Cancer Consortium | 000 | 1 | NIH | 9/9/2025 | $60,000 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K08AA032553 | Multimodal Approach for Diagnosis and Prognosis of Metabolic and Alcohol-Associated Steatotic Liver Diseases | 000 | 1 | NIH | 9/11/2025 | $202,176 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K08HL175205 | Toward Artificial Intelligence-enabled Automatic Echocardiography Reporting: A Study of Visual-Linguistic Foundation Model Frameworks | 000 | 1 | NIH | 9/10/2025 | $188,136 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R56DK141633 | CLINICAL SIGNIFICANCE OF SOMATIC MOSAIC STATES IN THE CONTEXT OF SHORT TELOMERES | 000 | 1 | NIH | 9/9/2025 | $150,000 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21CA302968 | CCNE1 is synthetically lethal with drug induced nuclear Cathepsin L (nCTSL) | 000 | 1 | NIH | 7/23/2025 | $412,429 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL176555 | Discovering aging-associated genetic modifiers and therapies for anthracycline-induced cardiotoxicity | 000 | 1 | NIH | 7/23/2025 | $680,583 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K23MD019644 | Screening Mammography: Early Breast Cancer Detection for All at Risk | 001 | 2 | NIH | 7/29/2025 | $155,520 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | OT2OD039849 | All of Us Biobank | 000 | 1 | NIH | 7/22/2025 | $80,770 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AG093316 | Multiomic analysis of downstream molecular effect of teloemre length in individual chromosome arms | 000 | 1 | NIH | 7/29/2025 | $441,100 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | OT2OD039849 | All of Us Biobank | 000 | 1 | NIH | 7/22/2025 | $13,400,000 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | OT2OD039849 | All of Us Biobank | 000 | 1 | NIH | 7/22/2025 | $5,751,974 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK132718 | Noninvasive assessment of portal hypertension and hepatic interstitial pressure with advanced magnetic resonance elastography | 000 | 3 | NIH | 2/27/2025 | $310,878 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL166238 | Electrochemical Catheter for Prevention of Central Line-Associated Bloodstream Infection | 000 | 3 | NIH | 2/19/2025 | $382,186 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01AI179609 | Mitochondrial Malfunction in T Cell Aging and Tissue Inflammation | 000 | 2 | NIH | 2/12/2025 | $563,609 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | TL1DK147565 | Next Generation KUH Researchers (GENERATOR) Training Core | 000 | 1 | NIH | 8/6/2025 | $882,138 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA272496 | Targeting PLK1 in RAS mutant chronic myelomonocytic leukemia | 001 | 3 | NIH | 5/29/2025 | $42,712 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA272496 | Targeting PLK1 in RAS mutant chronic myelomonocytic leukemia | 000 | 3 | NIH | 3/14/2025 | $384,419 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AG093815 | Digital detection of handwriting impairments in patients with atypical Alzheimer’s disease and frontotemporal dementia | 000 | 1 | NIH | 6/16/2025 | $441,100 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01AA026974 | Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) – Mayo Clinic | 003 | 7 | NIH | 8/27/2025 | $355,080 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG093767 | Premenopausal bilateral oophorectomy and biomarkers of Alzheimer’s and cerebrovascular diseases | 001 | 1 | NIH | 8/28/2025 | -$204,080 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG093767 | Premenopausal bilateral oophorectomy and biomarkers of Alzheimer’s and cerebrovascular diseases | 000 | 1 | NIH | 5/14/2025 | $1,979,481 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AI188373 | Ebola Virus Life Cycle Modeling In Vivo | 000 | 1 | NIH | 7/29/2025 | $441,100 |
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