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 | Issue Date FY: 2026 ( Subtotal = $43,686,122 ) (Continued on the next page) |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA288862 | NT-I7, a novel long-acting interleukin-7, in combination with anti-PD-1 checkpoint blockade for the treatment of glioablastoma | 000 | 2 | NIH | 1/13/2026 | $582,338 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA132878 | Post-translational Modifications in DNA Damage Response: a Structural Perspective | 000 | 13 | NIH | 12/30/2025 | $363,150 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AR085016 | A novel, clinically expedient, AAV-based gene therapy for bone healing | 000 | 2 | NIH | 2/5/2026 | $432,145 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA269384 | Re-purposing Oncolytic Virotherapy to Re-invigorate CAR T Cell Therapy for Solid Tumors. | 000 | 4 | NIH | 12/9/2025 | $327,341 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA248288 | Relating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and Risk | 000 | 6 | NIH | 2/12/2026 | $364,038 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AI165782 | Transport Mechanisms and Inhibition of Efflux Pumps in Pathogenic Organisms | 001 | 5 | NIH | 1/22/2026 | $813,289 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AI170535 | Characterizing the role of CSDE1 as a critical co-factor for VSV replication. | 000 | 4 | NIH | 2/18/2026 | $403,500 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AI162678 | Context dependent amino acid availability and sensing determines humoral immunity | 000 | 5 | NIH | 1/9/2026 | $470,828 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AR076347 | The Role of Cellular Senescence in Carpal Tunnel Syndrome | 000 | 6 | NIH | 12/5/2025 | $603,632 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AI195565 | Regulation of target cell survival by TBK1 and IKKe | 000 | 1 | NIH | 2/23/2026 | $624,521 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG083832 | Automated speech assessment for diagnosis of FTD spectrum disorders | 001 | 3 | NIH | 2/23/2026 | $80,413 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081584 | Biophysically inspired mechanical biomarkers of normal pressure hydrocephalus | 000 | 3 | NIH | 2/23/2026 | $403,500 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG083832 | Automated speech assessment for diagnosis of FTD spectrum disorders | 000 | 3 | NIH | 1/23/2026 | $723,711 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG087140 | Neuroinflammation, white matter integrity, AD biomarkers and pathology in corticobasal syndrome | 001 | 2 | NIH | 2/26/2026 | $79,802 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG087140 | Neuroinflammation, white matter integrity, AD biomarkers and pathology in corticobasal syndrome | 000 | 2 | NIH | 2/2/2026 | $718,230 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081955 | Validation of the Mayo Test Drive Screening Battery Composite and Stricker Learning Span for Early Detection and Monitoring of Cognitive Decline in Preclinical and Prodromal Alzheimer’s Disease | 001 | 3 | NIH | 2/24/2026 | $149,703 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081955 | Validation of the Mayo Test Drive Screening Battery Composite and Stricker Learning Span for Early Detection and Monitoring of Cognitive Decline in Preclinical and Prodromal Alzheimer’s Disease | 000 | 3 | NIH | 12/1/2025 | $1,347,320 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG097480 | Role of Brd4 in enhancing old donor heart preservation quality via 3D chromosomal restructuring | 000 | 1 | NIH | 1/28/2026 | $660,157 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG090601 | Prescription opioids, brain structure, and cognition in older adults with chronic pain | 001 | 2 | NIH | 3/2/2026 | $77,064 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG090601 | Prescription opioids, brain structure, and cognition in older adults with chronic pain | 000 | 2 | NIH | 2/6/2026 | $693,566 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG076469 | A novel cilium-to-nucleus axis promotes cellular senescence | 001 | 5 | NIH | 2/25/2026 | $32,595 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21CA277138 | Novel 3D DWI for Detection and Characterization of Prostate Cancer in Men with Pelvic Metal Implants | 000 | 3 | NIH | 12/11/2025 | $203,727 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AI190265 | C. albicans Induced Immune Skewing in Early Life | 000 | 1 | NIH | 2/3/2026 | $443,850 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AI188334 | Discovery of efflux pump inhibitors using a high-throughout bacterial assay | 001 | 2 | NIH | 12/29/2025 | $201,750 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AG097887 | Real world impact of glucagon-like peptide receptor agonist (GLP-1 RA) use on older adults | 000 | 1 | NIH | 3/13/2026 | $443,850 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01NS126227 | Seronegative Autoimmune Encephalopathies: Biomarker Discovery, Validation & Deep Phenotyping | 000 | 5 | NIH | 2/23/2026 | $397,500 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01NS113828 | Utilizing epidemiology, imaging and fluid biomarkers in MOG antibody-associated disease to inform prognosis, pathogenesis and therapeutics | 000 | 6 | NIH | 2/24/2026 | $638,605 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01NS103212 | CD8 T cell mediated disruption of Blood Brain Barrier Tight Junctions | 001 | 10 | NIH | 2/23/2026 | $593,164 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01NS076491 | Computational and Biological Approach to Flow Diversion | 000 | 15 | NIH | 12/10/2025 | $405,317 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL171097 | Unraveling the cell divergent roles of Glucocorticoid-Induced TNF-R Related Protein (GITR): A new opportunity to treat atherosclerosis using targeted immunotherapy | 000 | 2 | NIH | 2/16/2026 | $690,965 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL171056 | INTEGRATION OF MECHANICAL AND MOLECULAR CUES DURING DISTAL LUNG DEVELOPMENT | 000 | 3 | NIH | 3/6/2026 | $561,833 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01MH131623 | Uncovering the origin of hypermutability in adult brains | 000 | 3 | NIH | 12/10/2025 | $844,959 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL107304 | Epicardial remodeling in cardiomyopathy and cardiac aging | 000 | 14 | NIH | 2/23/2026 | $598,871 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL166238 | Electrochemical Catheter for Prevention of Central Line-Associated Bloodstream Infection | 000 | 4 | NIH | 2/13/2026 | $382,186 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL166140 | Targeting Mineralocorticoid Receptor Condensates to Optimize Donor Heart Preservation | 000 | 4 | NIH | 2/16/2026 | $646,056 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL160570 | Hydrogen Sulfide in Neonatal Airway Disease | 000 | 4 | NIH | 2/12/2026 | $566,606 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL160761 | Mechanisms of Clinical and Hemodynamic Response to Pulmonary Vasodilator Therapy in Fontan physiology | 000 | 5 | NIH | 2/23/2026 | $553,275 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL151379 | Evaluating the natural evolution of myocardial stiffness in aging, sex differences, and through menopause transition in women, using a free-breathing magnetic resonance elastography approach | 000 | 4 | NIH | 2/16/2026 | $554,891 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01GM144351 | Methods for microbiome compositional data | 001 | 5 | NIH | 3/10/2026 | $32,788 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01GM144351 | Methods for microbiome compositional data | 000 | 5 | NIH | 1/15/2026 | $295,088 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK136208 | Inhibition of autoimmune diabetes by ST8Sia6 | 000 | 3 | NIH | 2/28/2026 | $454,682 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK138998 | Characterization of microvasculature in kidney transplant by super-resolution ultrasound imaging | 000 | 3 | NIH | 2/26/2026 | $568,357 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK137231 | Engineering microcapsules for scalable differentiation of human pluripotent stem cells into hepatocytes | 000 | 3 | NIH | 2/13/2026 | $555,713 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK134448 | NAFLD Diagnosis and Outcomes | 000 | 3 | NIH | 1/14/2026 | $530,351 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01EB036987 | AI-assisted quantitative photon-counting-detector CT imaging for cytogenetic risk prediction and treatment response in multiple myeloma | 000 | 2 | NIH | 1/30/2026 | $474,398 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK142296 | Autophagic Processes and Hepatocellular Steatosis | 000 | 1 | NIH | 2/18/2026 | $495,130 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK139607 | Investigate the trafficking and function of polycystins in primary cilia and their implications for polycystic kidney disease | 000 | 3 | NIH | 1/9/2026 | $541,708 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK145578 | Reversing abnormal metabolism in mild autonomous cortisol secretion (MACS) | 000 | 1 | NIH | 2/17/2026 | $741,387 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01EB017095 | Diagnostic performance assessment and dose optimization using patient CT images: Application to deep-learning CT reconstruction and denoising technologies | 000 | 12 | NIH | 1/7/2026 | $421,277 |
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