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 | Issue Date FY: 2025 ( Subtotal = $279,541,055 ) (Continued on the next page) |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA271486 | Cooperativity of TMPRSS2-ERG fusion with p53 inactivation in prostate cancer pathogenesis | 000 | 4 | NIH | 2/28/2025 | $372,578 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K23MD016230 | Rural Patient Risks and Exposures for Diabetes ConTrol (Rural PREDICT) | 002 | 5 | NIH | 4/15/2025 | -$11,002 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | F30CA294722 | DNA aptamers as tools for toxin delivery to glioblastoma | 001 | 1 | NIH | 7/10/2025 | $0 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA275074 | Evaluation of novel tomosynthesis density measures in breast cancer risk prediction | 000 | 3 | NIH | 3/19/2025 | $604,359 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | F30CA294722 | DNA aptamers as tools for toxin delivery to glioblastoma | 000 | 1 | NIH | 7/10/2025 | $49,738 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01EB036987 | AI-assisted quantitative photon-counting-detector CT imaging for cytogenetic risk prediction and treatment response in multiple myeloma | 001 | 1 | NIH | 8/22/2025 | $78,124 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01EB036987 | AI-assisted quantitative photon-counting-detector CT imaging for cytogenetic risk prediction and treatment response in multiple myeloma | 000 | 1 | NIH | 3/19/2025 | $546,874 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01EB031790 | Super Resolution for Improved Multislice Prostate MRI | 001 | 4 | NIH | 6/25/2025 | $62,245 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01EB031790 | Super Resolution for Improved Multislice Prostate MRI | 000 | 4 | NIH | 3/17/2025 | $560,204 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL167796 | Targeting Senescence Specific Mechanisms of NF-κB Activation to Reverse Chronic Pulmonary Fibrosis | 001 | 2 | NIH | 7/16/2025 | $58,902 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL167796 | Targeting Senescence Specific Mechanisms of NF-κB Activation to Reverse Chronic Pulmonary Fibrosis | 000 | 2 | NIH | 3/5/2025 | $530,118 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA275074 | Evaluation of novel tomosynthesis density measures in breast cancer risk prediction | 001 | 3 | NIH | 5/22/2025 | $67,152 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R37CA276851 | Glioma intelligence from behind enemy lines | 001 | 3 | NIH | 5/29/2025 | $52,545 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R37CA276851 | Glioma intelligence from behind enemy lines | 000 | 3 | NIH | 3/3/2025 | $472,910 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | RF1AG058266 | Prevalence, etiology, and clinical implications of low count monoclonal B-cell lymphocytosis (MBL) | 000 | 6 | NIH | 8/15/2025 | $3,354,111 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL172948 | Understanding and addressing the lack of and delayed screening for primary Aldosteronism | 000 | 1 | NIH | 2/24/2025 | $726,611 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL172948 | Understanding and addressing the lack of and delayed screening for primary Aldosteronism | 001 | 1 | NIH | 4/3/2025 | -$726,611 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UH2CA299358 | Assay Validation of Cell-free DNA Amplified DNA Junctions for High Grade Glioma Monitoring | 000 | 1 | NIH | 8/1/2025 | $266,736 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL172948 | Understanding and addressing the lack of and delayed screening for primary Aldosteronism | 001 | 1 | NIH | 4/3/2025 | $726,611 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG076515 | Defining the interactions of senescent immune cells and skeletal cells | 001 | 4 | NIH | 6/17/2025 | $38,059 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K08DK127064 | Regulation of portal hypertension through neutrophil-platelet interactions in liver sinusoids | 002 | 5 | NIH | 4/23/2025 | $155,520 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG076515 | Defining the interactions of senescent immune cells and skeletal cells | 000 | 4 | NIH | 3/10/2025 | $428,154 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DC014942 | The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies | 001 | 8 | NIH | 4/21/2025 | $64,338 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DC014942 | The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies | 000 | 8 | NIH | 3/19/2025 | $579,047 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | P50CA210964 | Mayo Clinic Hepatobiliary SPORE | 001 | 5 | NIH | 3/10/2025 | $2,286,710 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG076469 | A novel cilium-to-nucleus axis promotes cellular senescence | 001 | 4 | NIH | 6/17/2025 | $26,076 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG076469 | A novel cilium-to-nucleus axis promotes cellular senescence | 000 | 4 | NIH | 3/6/2025 | $293,355 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03CA292132 | Targeting Ferroptosis in Cholangiocarcinoma with siRNA-based Nanovesicles | 000 | 1 | NIH | 7/23/2025 | $161,400 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AR085016 | A novel, clinically expedient, AAV-based gene therapy for bone healing | 000 | 1 | NIH | 1/31/2025 | $454,050 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA258239 | Novel multipronged Immunovirotherapy Approach for GBM Treatment | 001 | 5 | NIH | 5/22/2025 | $33,437 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA258239 | Novel multipronged Immunovirotherapy Approach for GBM Treatment | 000 | 5 | NIH | 3/4/2025 | $300,935 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL180379 | Epigenetic regulation of donor heart preservation mediated by Brd4 | 000 | 1 | NIH | 8/11/2025 | $739,562 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA283663 | Next-Generation Whole-Body MRI for Detection and Assessment of Therapy Response in Bone Lesions | 002 | 3 | NIH | 6/18/2025 | $582,617 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA298083 | Using germline and somatic genetics to elucidate glioma risk and improve patient outcomes | 000 | 1 | NIH | 8/18/2025 | $484,803 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03DE034500 | The Oral Microbiome and Cognitive Function | 000 | 1 | NIH | 8/14/2025 | $332,787 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AA031965 | Neurosteroids and Alcohol Use Disorder | 000 | 1 | NIH | 9/4/2025 | $734,283 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR085562 | TFEB and age-associated B cells in autoimmunity | 000 | 1 | NIH | 9/5/2025 | $127,273 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR085562 | TFEB and age-associated B cells in autoimmunity | 000 | 1 | NIH | 9/5/2025 | $250,000 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL174650 | A population-based study of deep learning measures of breast arterial calcification for improving women's health using repurposed mammogram images | 000 | 1 | NIH | 8/29/2025 | $756,906 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK141438 | Role of Extracellular Vesicle: Autophagy Pathway Crosstalk in Type 2 Diabetes Pathogenesis | 000 | 1 | NIH | 9/4/2025 | $2,325,005 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR084242 | Leveraging Large Language Models to Automate and Improve Accuracy of Medical Registry Curation | 000 | 1 | NIH | 9/11/2025 | $377,273 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UH3NS132128 | Hybrid approach for comprehensive mutation detection in a cell | 000 | 3 | NIH | 9/10/2025 | $562,405 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AA031167 | Multi-site DBS with precise timing control focusing on synaptic plasticity | 000 | 1 | NIH | 8/29/2025 | $539,237 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UH3NS123066 | Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEG | 000 | 3 | NIH | 9/10/2025 | $699,582 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21CA302802 | Using Vagal Nerve Stimulation in Conjunction with NRT for Smoking Cessation | 000 | 1 | NIH | 9/3/2025 | $411,939 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03DK139233 | Sphingolipid Metabolism Controls Regulatory T cell Function and Intestinal Homeostasis | 000 | 1 | NIH | 9/4/2025 | $242,100 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01DK144994 | T1D-DN KPMP Urban Rural (T1D-DN KUR) Recruitment Site | 000 | 1 | NIH | 8/28/2025 | $790,565 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | RF1AG090341 | Advancing women’s care in Alzheimer’s disease and other dementias through EHR | 000 | 1 | NIH | 9/8/2025 | $3,377,863 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01LM014760 | Virtual World-based Cardiac Rehabilitation to Promote Data-Powered Cardiovascular Health Among Cardiac Patients: A Multicenter Randomized Clinical Trial | 000 | 1 | NIH | 9/9/2025 | $390,852 |
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