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 | Issue Date FY: 2025 ( Subtotal = $290,064,443 ) (Continued on the next page) |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R37CA276851 | Glioma intelligence from behind enemy lines | 001 | 3 | NIH | 5/29/2025 | $52,545 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R37CA276851 | Glioma intelligence from behind enemy lines | 000 | 3 | NIH | 3/3/2025 | $472,910 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | RF1AG058266 | Prevalence, etiology, and clinical implications of low count monoclonal B-cell lymphocytosis (MBL) | 000 | 6 | NIH | 8/15/2025 | $3,354,111 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL172948 | Understanding and addressing the lack of and delayed screening for primary Aldosteronism | 001 | 1 | NIH | 4/3/2025 | -$726,611 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | P50CA210964 | Mayo Clinic Hepatobiliary SPORE | 001 | 5 | NIH | 3/10/2025 | $2,286,710 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL172948 | Understanding and addressing the lack of and delayed screening for primary Aldosteronism | 001 | 1 | NIH | 4/3/2025 | $726,611 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK141438 | Role of Extracellular Vesicle: Autophagy Pathway Crosstalk in Type 2 Diabetes Pathogenesis | 000 | 1 | NIH | 9/4/2025 | $2,325,005 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03DK139233 | Sphingolipid Metabolism Controls Regulatory T cell Function and Intestinal Homeostasis | 000 | 1 | NIH | 9/4/2025 | $242,100 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21CA302802 | Using Vagal Nerve Stimulation in Conjunction with NRT for Smoking Cessation | 000 | 1 | NIH | 9/3/2025 | $411,939 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR085562 | TFEB and age-associated B cells in autoimmunity | 000 | 1 | NIH | 9/5/2025 | $127,273 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL174650 | A population-based study of deep learning measures of breast arterial calcification for improving women's health using repurposed mammogram images | 000 | 1 | NIH | 8/29/2025 | $756,906 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR085562 | TFEB and age-associated B cells in autoimmunity | 000 | 1 | NIH | 9/5/2025 | $250,000 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR084242 | Leveraging Large Language Models to Automate and Improve Accuracy of Medical Registry Curation | 000 | 1 | NIH | 9/11/2025 | $377,273 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | RF1AG090341 | Advancing women’s care in Alzheimer’s disease and other dementias through EHR | 000 | 1 | NIH | 9/8/2025 | $3,377,863 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UH3NS123066 | Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEG | 000 | 3 | NIH | 9/10/2025 | $699,582 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UH3NS132128 | Hybrid approach for comprehensive mutation detection in a cell | 000 | 3 | NIH | 9/10/2025 | $562,405 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AA031965 | Neurosteroids and Alcohol Use Disorder | 000 | 1 | NIH | 9/4/2025 | $734,283 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | F32DK145067 | The role of sympathetic signaling in inflammation-induced colon dysfunction and recovery | 001 | 1 | NIH | 7/31/2025 | $0 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | F32DK145067 | The role of sympathetic signaling in inflammation-induced colon dysfunction and recovery | 000 | 1 | NIH | 7/31/2025 | $75,520 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R33AT012185 | MRI-based quantitative characterization of impaired myofascial interface properties in myofascial pain syndrome | 000 | 2 | NIH | 8/12/2025 | $1,578,672 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03OD039975 | Rare variant analysis integrating large public DNA sequencing controls and gene expression data for discovering novel predisposition genes of orofacial clefts | 000 | 1 | NIH | 6/10/2025 | $1 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03OD039975 | Rare variant analysis integrating large public DNA sequencing controls and gene expression data for discovering novel predisposition genes of orofacial clefts | 000 | 1 | NIH | 6/10/2025 | $320,799 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01CA271410 | Mayo Clinic Center for Clinical Proteomics | 001 | 4 | NIH | 7/29/2025 | $1,115,210 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01AA026974 | Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) – Mayo Clinic | 003 | 7 | NIH | 8/27/2025 | $355,080 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01AI179609 | Mitochondrial Malfunction in T Cell Aging and Tissue Inflammation | 000 | 2 | NIH | 2/12/2025 | $563,609 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | TL1DK147565 | Next Generation KUH Researchers (GENERATOR) Training Core | 000 | 1 | NIH | 8/6/2025 | $882,138 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA265050 | New Therapuetics for Pancreatic Cancer | 001 | 4 | NIH | 6/9/2025 | $598,329 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA272496 | Targeting PLK1 in RAS mutant chronic myelomonocytic leukemia | 001 | 3 | NIH | 5/29/2025 | $42,712 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA272496 | Targeting PLK1 in RAS mutant chronic myelomonocytic leukemia | 000 | 3 | NIH | 3/14/2025 | $384,419 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081584 | Biophysically inspired mechanical biomarkers of normal pressure hydrocephalus | 001 | 2 | NIH | 6/10/2025 | $32,280 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081584 | Biophysically inspired mechanical biomarkers of normal pressure hydrocephalus | 000 | 2 | NIH | 3/20/2025 | $363,150 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21CA302968 | CCNE1 is synthetically lethal with drug induced nuclear Cathepsin L (nCTSL) | 000 | 1 | NIH | 7/23/2025 | $412,429 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL176555 | Discovering aging-associated genetic modifiers and therapies for anthracycline-induced cardiotoxicity | 000 | 1 | NIH | 7/23/2025 | $680,583 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | OT2OD039849 | All of Us Biobank | 000 | 1 | NIH | 7/22/2025 | $80,770 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AG093316 | Multiomic analysis of downstream molecular effect of teloemre length in individual chromosome arms | 000 | 1 | NIH | 7/29/2025 | $441,100 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | OT2OD039849 | All of Us Biobank | 000 | 1 | NIH | 7/22/2025 | $13,400,000 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AI187691 | Antagonistic actions of IRF4 and BACH2 in regulating Germinal Center B cell fates and promoting Lymphomagenesis | 000 | 1 | NIH | 7/23/2025 | $441,098 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | OT2OD039849 | All of Us Biobank | 000 | 1 | NIH | 7/22/2025 | $5,751,974 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AI188373 | Ebola Virus Life Cycle Modeling In Vivo | 000 | 1 | NIH | 7/29/2025 | $441,100 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL180379 | Epigenetic regulation of donor heart preservation mediated by Brd4 | 000 | 1 | NIH | 8/11/2025 | $739,562 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA298083 | Using germline and somatic genetics to elucidate glioma risk and improve patient outcomes | 000 | 1 | NIH | 8/18/2025 | $484,803 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK098468 | Role of Circadian Misalignment in Beta-cell Failure in Type 2 Diabetes | 001 | 14 | NIH | 6/30/2025 | $516,603 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AR083873 | Local Delivery of AdipoRon to Treat Arthrofibrosis | 000 | 1 | NIH | 7/7/2025 | $342,975 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R03DE034500 | The Oral Microbiome and Cognitive Function | 000 | 1 | NIH | 8/14/2025 | $332,787 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01NS144593 | Antibody Drug Conjugate Designs to Enhance the Therapeutic Window for Brain Tumors | 000 | 1 | NIH | 7/30/2025 | $652,751 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K23MD019644 | Screening Mammography: Early Breast Cancer Detection for All at Risk | 001 | 2 | NIH | 7/29/2025 | $155,520 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG044615 | Respiratory Control in Old Age | 002 | 13 | NIH | 7/31/2025 | $602,958 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U2CDK143937 | Next Generation KUH Researchers (GENERATOR) | 000 | 1 | NIH | 8/14/2025 | $368,742 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK122948 | Lipotoxicity and Liver Inflammation | 001 | 6 | NIH | 2/28/2025 | $525,565 |
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