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 | Issue Date FY: 2026 ( Subtotal = $6,262,740 ) |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AR076347 | The Role of Cellular Senescence in Carpal Tunnel Syndrome | 000 | 6 | NIH | 12/5/2025 | $603,632 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01NS076491 | Computational and Biological Approach to Flow Diversion | 000 | 15 | NIH | 12/10/2025 | $405,317 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA273027 | Role of MALT1 in regulating the breast cancer immune microenvironment | 000 | 4 | NIH | 12/5/2025 | $489,319 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA269384 | Re-purposing Oncolytic Virotherapy to Re-invigorate CAR T Cell Therapy for Solid Tumors. | 000 | 4 | NIH | 12/9/2025 | $327,341 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG076636 | Advancing MR elastography to map mechanical signatures of key AD/ADRD processes | 000 | 4 | NIH | 11/26/2025 | $397,775 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K99AG090620 | T cell surveillance of senescent cells under homeostasis and aging | 000 | 2 | NIH | 12/10/2025 | $133,353 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01MH131623 | Uncovering the origin of hypermutability in adult brains | 000 | 3 | NIH | 12/10/2025 | $844,959 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21CA277138 | Novel 3D DWI for Detection and Characterization of Prostate Cancer in Men with Pelvic Metal Implants | 000 | 3 | NIH | 12/11/2025 | $203,727 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R37CA266344 | Towards Safer and More Effective CART Cell Therapy Through the Modulation of Myeloid Cytokines | 000 | 5 | NIH | 12/5/2025 | $554,542 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA288753 | Ovcoming PARP Inhibitor Resistance | 000 | 2 | NIH | 12/10/2025 | $570,333 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA285439 | Preclinical and clinical characterization of DNMT inhibitors +/- standard chemoimmunotherapy in TNBC | 000 | 2 | NIH | 12/10/2025 | $417,118 |
| | 2026 | 2026 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG081955 | Validation of the Mayo Test Drive Screening Battery Composite and Stricker Learning Span for Early Detection and Monitoring of Cognitive Decline in Preclinical and Prodromal Alzheimer’s Disease | 000 | 3 | NIH | 12/1/2025 | $1,347,320 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01FD007842 | Development of the brain penetrant ATM inhibitor WSD0628 in combination with radiation for recurrent high grade glioma | 000 | 2 | FDA | 11/20/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | P50CA210964 | Mayo Clinic Hepatobiliary SPORE | 000 | 7 | NIH | 12/4/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01CA271410 | Mayo Clinic Center for Clinical Proteomics | 000 | 4 | NIH | 11/24/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | K99HL171911 | The role of proteoglycans in Heparin-induced thrombocytopenia: Implications for pathophysiology, diagnosis and treatment | 000 | 2 | NIH | 12/12/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R34MH128296 | Evaluating the feasibility of a primary care-based treatment for restrictive eating disorders in children and adolescents | 000 | 3 | NIH | 11/21/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 000 | 50 | NIH | 12/2/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA256927 | Targeting dual functions of PD-L1 for cancer therapy | 000 | 5 | NIH | 10/7/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG065154 | Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial | 000 | 5 | NIH | 11/14/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK130331 | Lipid metabolism and adipose tissue function | 000 | 4 | NIH | 10/10/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK131685 | Noninvasive assessment of detrusor pressure and dysfunction | 000 | 4 | NIH | 12/1/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG071686 | Systemic Cell Senescence as a Mediator of Brain Aging Through Circulation | 000 | 5 | NIH | 12/3/2025 | $0 |
| | 2026 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA248147 | Serial immunotherapy combination to modulate the tumor environment in patients with metastatic gastroesophageal cancer | 000 | 5 | NIH | 10/7/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U24DK112326 | Mayo Clinic Physical Activity Research Center: Metabolomics and Proteomics Analysis Site | 000 | 7 | NIH | 12/8/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01DK108288 | The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer | 000 | 10 | NIH | 11/26/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | U01DK108288 | The Exocrine and Endocrine Pancreas in Type 2 Diabetes, Pancreatitis and Cancer | 000 | 10 | NIH | 11/26/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA225996 | BAK Autoactivation in Hematological Malignancies | 000 | 5 | NIH | 11/26/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01NR018832 | Improving Cardiac Rehabilitation outcomes through mobile case management (iCARE) | 000 | 5 | NIH | 12/11/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UG1CA232760 | NCI, National Clinical Trials Network Lead Academic Participating Site (LAPS) UG1 | 000 | 6 | NIH | 12/1/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AG072898 | Chronic Alcohol Exposure and Pathophysiology of Alzheimer's Disease. | 000 | 5 | NIH | 12/2/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA242023 | Regulation of pten tumor suppressive functions by C-tail phosphorylation. | 000 | 5 | NIH | 11/19/2025 | $0 |
| | 2026 | 2024 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA237398 | Role of Nuclear Pore-Regulated Mechanisms in Prostate Cancer Aggressiveness | 000 | 6 | NIH | 11/20/2025 | $0 |
| | 2026 | 2023 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01MH122258 | CRCNS: Processing speed in the human connectome across the lifespan | 000 | 5 | NIH | 11/24/2025 | $0 |
| | 2026 | 2023 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AA030184 | Transcriptional adaptations driving the intensification of alcohol-seeking in dependent rats undergoing prolonged abstinence | 000 | 3 | NIH | 12/5/2025 | -$3,521 |
| | 2026 | 2023 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01CA239548 | Using Label-free Ultrasound Angio-Morphometry Analysis for Improving Ultrasound Specificity in Breast Cancer Detection and Treatment Monitoring | 000 | 5 | NIH | 12/2/2025 | -$2,803 |
| | 2026 | 2023 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21NS130297 | Harnessing the latent heat of saline evaporation for safe and effective endovascular therapeutic organ cooling | 000 | 1 | NIH | 11/25/2025 | -$25,672 |
| | 2026 | 2023 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01MH124655 | A Randomized Controlled Trial of Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents with Suicidal Ideation Associated with Major Depressive Disorder | 000 | 4 | NIH | 12/9/2025 | $0 |
| | 2026 | 2022 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01HL141112 | Studies of mRNA translational regulations in erythropoiesis | 000 | 5 | NIH | 12/4/2025 | $0 |
|
| Issue Date FY: 2025 ( Subtotal = $290,064,443 ) (Continued on the next page) |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AA031167 | Multi-site DBS with precise timing control focusing on synaptic plasticity | 000 | 1 | NIH | 8/29/2025 | $539,237 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01LM014760 | Virtual World-based Cardiac Rehabilitation to Promote Data-Powered Cardiovascular Health Among Cardiac Patients: A Multicenter Randomized Clinical Trial | 001 | 1 | NIH | 9/22/2025 | $0 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR084242 | Leveraging Large Language Models to Automate and Improve Accuracy of Medical Registry Curation | 000 | 1 | NIH | 9/11/2025 | $377,273 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01LM014760 | Virtual World-based Cardiac Rehabilitation to Promote Data-Powered Cardiovascular Health Among Cardiac Patients: A Multicenter Randomized Clinical Trial | 000 | 1 | NIH | 9/9/2025 | $390,852 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | UH3NS132128 | Hybrid approach for comprehensive mutation detection in a cell | 000 | 3 | NIH | 9/10/2025 | $562,405 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01AA031965 | Neurosteroids and Alcohol Use Disorder | 000 | 1 | NIH | 9/4/2025 | $734,283 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR085562 | TFEB and age-associated B cells in autoimmunity | 000 | 1 | NIH | 9/5/2025 | $127,273 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R01DK141438 | Role of Extracellular Vesicle: Autophagy Pathway Crosstalk in Type 2 Diabetes Pathogenesis | 000 | 1 | NIH | 9/4/2025 | $2,325,005 |
| | 2025 | 2025 | MAYO CLINIC | 200 1ST ST SW | ROCHESTER | MN | 55905-0001 | OLMSTED | USA | R21AR085562 | TFEB and age-associated B cells in autoimmunity | 000 | 1 | NIH | 9/5/2025 | $250,000 |
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