Saturday, August 23, 2025 8/23/2025

Molecular characterization of the role for metabolites in immune cell differentiation

Award Number: R01AI061061
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2004
PERIOD OF PERFORMANCE END DATE: 07/31/2027

Group Awards By:

View Award Description

Molecular characterization of the role for metabolites in immune cell differentiation - Abstract The dynamic regulation of metabolic states plays an active role in cellular differentiation decisions, and this occurs throughout mammalian development. The conservation of these processes in different species, developmental settings, and immune cell types suggests metabolism influences common mechanistic events needed for differentiation decisions in diverse cellular backgrounds. However, the interpretation of these conserved mechanisms must have a component of cell-type specificity to properly regulate the genome to promote appropriate differentiation in individual cellular settings. Therefore, it is important to define the conserved and cell-type specific mechanistic principles to understand how dietary and metabolic interventions influence immune cell differentiation in the context of healthy and disease states. In the previous funding cycle of this grant, we identified a role for alpha-ketoglutarate (aKG) in regulating the IL-2-sensitive gene program in T cells. Mechanistically, aKG-sensitive events enhanced the association of CTCF with a subset of sites in CD4+ T cells, and together with studies in cancer cells, the data indicated this overall activity is conserved in diverse cell-types. The data also suggested these events are interpreted in a cell-type specific manner, potentially based on the enhancer landscape of the cell. In this grant, we will extend these findings to address how aKG-sensitive CTCF sites are selected, and whether there are any cell-type dependent mechanisms selecting these sites. We will also define whether downstream mechanisms, such as enhancer activity, have sensitivity to metabolic states. In this context, we will address whether the enhancer landscape is regulated by short chain fatty acids such as butyrate and acetate. We will also define which aspects of metabolite-sensitive mechanisms are conserved between species, and how variation between the mouse and human genome influences the interpretation of conserved and cell-type specific events. Information gained in these studies will be critical for predicting the role for metabolic and dietary interventions in the treatment of immunological diseases and in promoting effective immune responses to infectious diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $854,834 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Allergy and Infectious Diseases Research	004	20	8/12/2025	EXTENSION WITH OR WITHOUT FUNDS	$854,834
2025	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Allergy and Infectious Diseases Research	002	19	2/24/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$695,144
2025	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Allergy and Infectious Diseases Research	003	19	8/12/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	18	2/24/2025	NON-COMPETING CONTINUATION	-$445,494
2025	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	17	2/24/2025	COMPETING CONTINUATION	-$249,650
														Subtotal = $854,834

Issue Date FY: 2024 ( Subtotal = $443,417 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Allergy and Infectious Diseases Research	001	19	7/23/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$443,417
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	18	7/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $443,417

Issue Date FY: 2023 ( Subtotal = $766,280 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	18	7/13/2023	NON-COMPETING CONTINUATION	$445,494
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	17	9/19/2023	COMPETING CONTINUATION	$320,786
														Subtotal = $766,280

Issue Date FY: 2022 ( Subtotal = $184,157 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	17	9/27/2022	COMPETING CONTINUATION	$439,548
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	16	12/7/2021	NON-COMPETING CONTINUATION	-$255,391
														Subtotal = $184,157

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	16	7/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $367,500 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	16	2/12/2020	NON-COMPETING CONTINUATION	$367,500
														Subtotal = $367,500

Issue Date FY: 2019 ( Subtotal = $367,500 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	15	2/13/2019	NON-COMPETING CONTINUATION	$367,500
														Subtotal = $367,500

Issue Date FY: 2018 ( Subtotal = $367,500 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	14	2/8/2018	NON-COMPETING CONTINUATION	$367,500
														Subtotal = $367,500

Issue Date FY: 2017 ( Subtotal = $367,500 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	13	2/16/2017	NON-COMPETING CONTINUATION	$367,500
														Subtotal = $367,500

Issue Date FY: 2016 ( Subtotal = $367,500 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	002	12	3/10/2016	COMPETING CONTINUATION	$367,500
2016	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	352940111	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	11	3/4/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2016	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	352940111	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	11	2/19/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $367,500

Issue Date FY: 2014 ( Subtotal = $327,443 )
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	002	10	3/25/2014	NON-COMPETING CONTINUATION	-$347,490
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	001	10	2/24/2014	NON-COMPETING CONTINUATION	$34,749
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Allergy and Infectious Diseases Research	003	11	3/25/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$327,443
2014	2014	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	10	1/29/2014	NON-COMPETING CONTINUATION	$312,741
														Subtotal = $327,443

Issue Date FY: 2013 ( Subtotal = $326,641 )
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	001	9	8/8/2013	NON-COMPETING CONTINUATION	$13,900
2013	2013	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	9	1/15/2013	NON-COMPETING CONTINUATION	$312,741
														Subtotal = $326,641

Issue Date FY: 2012 ( Subtotal = $347,490 )
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	8	1/26/2012	NON-COMPETING CONTINUATION	$347,490
														Subtotal = $347,490

Issue Date FY: 2011 ( Subtotal = $347,490 )
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	001	7	6/6/2011	NON-COMPETING CONTINUATION	$31,590
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	7	1/13/2011	NON-COMPETING CONTINUATION	$315,900
														Subtotal = $347,490

Issue Date FY: 2010 ( Subtotal = $146,250 )
2010	2010	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	6	2/11/2010	COMPETING CONTINUATION	$146,250
														Subtotal = $146,250

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2008	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	5	9/17/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2008 ( Subtotal = $282,026 )
2008	2008	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	5	6/25/2008	NON-COMPETING CONTINUATION	$282,026
														Subtotal = $282,026

Issue Date FY: 2007 ( Subtotal = $287,488 )
2007	2007	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Allergy and Infectious Diseases Research	000	4	6/4/2007	NON-COMPETING CONTINUATION	$287,488
														Subtotal = $287,488

Grand Total All Awards = $7,078,492

Page 1 of 2 (56 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Molecular characterization of the role for metabolites in immune cell differentiation

Award Number: R01AI061061

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2004

PERIOD OF PERFORMANCE END DATE: 07/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer