Friday, January 2, 2026 1/2/2026

Genome Evolution During Bacterial Persistence in the Human Airways in COPD

Award Number: R01AI019641
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1983
PERIOD OF PERFORMANCE END DATE: 06/30/2024

Group Awards By:

View Award Description

Genome Evolution During Bacterial Persistence in the Human Airways in COPD - Chronic obstructive pulmonary disease (COPD) is a chronic debilitating disease that afflicts ~24 million Americans and is the fourth leading cause of death in the US and in the world. The lower airway microbiome of adults with COPD harbors bacterial pathogens that are absent in the lower airway microbiome of healthy people. In rigorous prospective studies, nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are by far the most common bacterial pathogens that persist in the lower airways in COPD. The presence of these pathogens in the lower airways has profound consequences on the clinical course and pathogenesis of the disease. Persistent bacteria induce airway inflammation that results in increased symptoms, enormous morbidity, and also leads to acceleration of the progressive loss of lung function that leads to early mortality in COPD. Our work over the last five years has provided key observations to guide the work proposed here to advance the field by identifying mechanisms by which these exclusively human pathogens persist in the unique environment of COPD airways. For example, while NTHi and Mcat are classically considered to be extracellular pathogens, multiple lines of evidence now show that both pathogens invade and survive in human respiratory epithelial cells and macrophages, resulting in a reservoir of intracellular bacteria that resist clearance by antibiotics and host mechanisms. In aim 1, we will elucidate the evolutionary dynamics of bacterial pathogens in the natural environment of the human COPD airways by analyzing the genomes of serial isolates of strains of NTHi and Mcat that have persisted for months to years. In aim 2, we will examine transcriptional profiles of serial isolates of persistent strains and transcripts from fresh sputum samples collected from adults with COPD with persistent NTHi and Mcat to identify gene products that undergo changes that enable persistence in COPD airways. In Aim 3, guided by dynamic changes in genomes and transcriptomes in human airways, we will elucidate mechanisms that mediate persistence of NTHi and Mcat using relevant model systems. This work will lead directly to an innovative approach of identifying specific targets for intervention through pathogen-specific eradication and/or anti-virulence antimicrobial agents, which would leave the normal microbiota undisturbed. This approach has far-reaching clinical benefits, representing a completely novel approach to treating bacterial infection in COPD, which has relied on traditional antibiotics for 70 years.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	37	12/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $510,716 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	37	7/3/2023	NON-COMPETING CONTINUATION	$510,716
														Subtotal = $510,716

Issue Date FY: 2022 ( Subtotal = $515,722 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	36	6/24/2022	NON-COMPETING CONTINUATION	$515,722
														Subtotal = $515,722

Issue Date FY: 2021 ( Subtotal = $518,951 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	35	7/6/2021	NON-COMPETING CONTINUATION	$518,951
														Subtotal = $518,951

Issue Date FY: 2020 ( Subtotal = $537,008 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	003	34	6/24/2020	NON-COMPETING CONTINUATION	$537,008
2020	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	001	33	3/18/2020	COMPETING CONTINUATION	$13,377
2020	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	32	3/18/2020	NON-COMPETING CONTINUATION	-$13,377
2020	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	002	32	6/10/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $537,008

Issue Date FY: 2019 ( Subtotal = $570,901 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	33	7/1/2019	COMPETING CONTINUATION	$570,901
														Subtotal = $570,901

Issue Date FY: 2017 ( Subtotal = $451,963 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	002	32	8/9/2017	NON-COMPETING CONTINUATION	$451,963
2017	2016	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	001	31	3/7/2017	EXTENSION WITH OR WITHOUT FUNDS	$160,737
2017	2015	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	30	3/7/2017	NON-COMPETING CONTINUATION	-$160,737
														Subtotal = $451,963

Issue Date FY: 2016 ( Subtotal = $451,963 )
2016	2016	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Allergy and Infectious Diseases Research	000	31	8/2/2016	EXTENSION WITH OR WITHOUT FUNDS	$451,963
														Subtotal = $451,963

Issue Date FY: 2015 ( Subtotal = $772,946 )
2015	2015	SUNY, BUFFALO	UB Commons, Ste 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	002	30	8/25/2015	NON-COMPETING CONTINUATION	$0
2015	2015	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Allergy and Infectious Diseases Research	001	30	8/21/2015	NON-COMPETING CONTINUATION	$320,297
2015	2015	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Allergy and Infectious Diseases Research	000	30	8/7/2015	NON-COMPETING CONTINUATION	$452,649
														Subtotal = $772,946

Issue Date FY: 2014 ( Subtotal = $475,643 )
2014	2014	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Allergy and Infectious Diseases Research	000	29	7/29/2014	NON-COMPETING CONTINUATION	$475,643
														Subtotal = $475,643

Issue Date FY: 2013 ( Subtotal = $455,369 )
2013	2013	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	Allergy and Infectious Diseases Research	001	28	9/20/2013	COMPETING CONTINUATION	$455,369
2013	2012	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	000	27	9/19/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $455,369

Issue Date FY: 2012 ( Subtotal = $306,956 )
2012	2012	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	000	27	1/24/2012	NON-COMPETING CONTINUATION	$306,956
														Subtotal = $306,956

Issue Date FY: 2011 ( Subtotal = $306,956 )
2011	2011	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	000	26	11/3/2010	NON-COMPETING CONTINUATION	$279,051
2011	2011	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	001	26	7/5/2011	NON-COMPETING CONTINUATION	$27,905
														Subtotal = $306,956

Issue Date FY: 2010 ( Subtotal = $310,057 )
2010	2010	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	001	25	5/10/2010	NON-COMPETING CONTINUATION	$28,187
2010	2010	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	000	25	12/14/2009	NON-COMPETING CONTINUATION	$281,870
														Subtotal = $310,057

Issue Date FY: 2009 ( Subtotal = $313,189 )
2009	2009	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	000	24	12/3/2008	NON-COMPETING CONTINUATION	$281,870
2009	2009	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	P.O. BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	001	24	7/9/2009	NON-COMPETING CONTINUATION	$31,319
														Subtotal = $313,189

Issue Date FY: 2008 ( Subtotal = $313,189 )
2008	2008	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Allergy and Infectious Diseases Research	000	23	12/20/2007	COMPETING CONTINUATION	$313,189
														Subtotal = $313,189

Issue Date FY: 2006 ( Subtotal = $246,078 )
2006	2006	SUNY, BUFFALO	UB Commons, Ste 211	AMHERST	NY	14228	ERIE	USA	Allergy and Infectious Diseases Research	000	22	2/15/2006	NON-COMPETING CONTINUATION	$246,078
														Subtotal = $246,078

Issue Date FY: 2005 ( Subtotal = $252,000 )
2005	2005	SUNY, BUFFALO	UB Commons, Ste 211	AMHERST	NY	14228	ERIE	USA	Microbiology and Infectious Diseases Research	000	21	2/11/2005	NON-COMPETING CONTINUATION	$252,000
														Subtotal = $252,000

Issue Date FY: 2004 ( Subtotal = $252,000 )
2004	2004	SUNY, BUFFALO	UB Commons, Ste 211	AMHERST	NY	14228	ERIE	USA	Microbiology and Infectious Diseases Research	000	20	2/23/2004	NON-COMPETING CONTINUATION	$252,000
														Subtotal = $252,000

Issue Date FY: 2003 ( Subtotal = $252,000 ) (Continued on the next page)
Grand Total All Awards = $8,340,750

Page 1 of 2 (57 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Genome Evolution During Bacterial Persistence in the Human Airways in COPD

Award Number: R01AI019641

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1983

PERIOD OF PERFORMANCE END DATE: 06/30/2024

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer