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The development of alcohol misuse and related problems from adolescence to early midlife

Award Number: R01AA015416
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2005
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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The development of alcohol misuse and related problems from adolescence to early midlife - Project Summary The goal of this competing continuation is to examine the antecedents and health consequences of alcohol misuse from adolescence through early midlife (the 30s). There is a paucity of longitudinal studies on alcohol misuse that extend through early midlife in the general population, and the existing knowledge base comes from studies of singletons, which are prone to confounding. We propose to address these limitations by bringing together two longitudinal studies of Finnish twins, FinnTwin12 (FT12) and FinnTwin16 (FT16), ns = 5178 and 5563, ~50% female. The innovative longitudinal twin design, which allows us to control for confounding factors through the comparison of exposures and outcomes within families and within individuals, will add much needed rigor to our understanding of the antecedents and consequences of alcohol misuse through early midlife. FT12 was recruited at age 12 and subsequently assessed at ages 14, 17, and 22. Under this renewal, we will conduct an early midlife (age 35) assessment of the FT12 twins (online surveys regarding their current health, behavior, and environments; a salivary DNA sample; and, for a subsample of participants who have been intensively studied since age 14, diagnostic psychiatric and life history calendar interviews and laboratory-based neurocognitive and health measures) and the twins’ spouses (online survey only). FT16 was recruited at age 16 and subsequently assessed at ages 17, 18, 25, and 35. Finland offers a unique environment for conducting the proposed research, including record linkage to comprehensive national registries and a modern biobanking infrastructure. Guided by a multilevel developmental contextual framework, our aims are to: (1) Characterize patterns of alcohol misuse from adolescence to early midlife. (2) Identify factors associated with trajectories of alcohol misuse between adolescence and early midlife. These include person-level factors such as polygenic predispositions, personality, and neurocognitive functioning; environmental factors such as parents, peers, spouses/partners, life events, parenthood, employment, and education; and internalizing, externalizing, and other substance use problems. (3) Examine the health outcomes associated with trajectories of alcohol misuse, including measures of physical health, sleep, and life satisfaction. Finally, we will examine the generalizability of effects using the U.S. nationally representative Add Health sample (n = 20,745), which has comparable measures and assessments, including a sibling component. The results will provide important information about alcohol misuse and its consequences through the understudied early midlife period. Through partnerships with collaborators in the arts and mass communications, we will translate and disseminate our findings to the public through nontraditional creative content to increase accessibility of scientific results. In sum, this project will contribute to NIAAA’s goals to identify factors associated with alcohol misuse across the lifespan; delineate the effects of alcohol misuse on health; and enhance the public health impact of research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = -$16 )
2027	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Alcohol Research Programs	000	16	10/9/2026	NON-COMPETING CONTINUATION	-$16
														Subtotal = -$16

Issue Date FY: 2025 ( Subtotal = -$52,963 )
2025	2021	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	13	7/14/2025	NON-COMPETING CONTINUATION	$0
2025	2021	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	001	13	7/14/2025	NON-COMPETING CONTINUATION	-$52,963
														Subtotal = -$52,963

Issue Date FY: 2024 ( Subtotal = $553,762 )
2024	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Alcohol Research Programs	000	16	6/7/2024	NON-COMPETING CONTINUATION	$553,762
														Subtotal = $553,762

Issue Date FY: 2023 ( Subtotal = $564,320 )
2023	2023	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Alcohol Research Programs	000	15	6/1/2023	NON-COMPETING CONTINUATION	$564,320
														Subtotal = $564,320

Issue Date FY: 2022 ( Subtotal = $598,572 )
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Alcohol Research Programs	001	14	7/26/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$598,572
2022	2022	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Alcohol Research Programs	004	14	9/9/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$624,802
2022	2021	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	13	7/26/2022	NON-COMPETING CONTINUATION	$0
2022	2021	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	003	13	9/9/2022	NON-COMPETING CONTINUATION	-$607,181
2022	2020	VIRGINIA COMMONWEALTH UNIVERSITY	910 WEST FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	002	12	9/9/2022	COMPETING CONTINUATION	-$17,621
														Subtotal = $598,572

Issue Date FY: 2021 ( Subtotal = $607,181 )
2021	2021	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	002	13	5/18/2021	NON-COMPETING CONTINUATION	$607,181
2021	2021	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	003	13	8/2/2021	NON-COMPETING CONTINUATION	$0
2021	2020	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	001	12	11/13/2020	COMPETING CONTINUATION	$14,784
2021	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	11	11/13/2020	NON-COMPETING CONTINUATION	-$14,784
														Subtotal = $607,181

Issue Date FY: 2020 ( Subtotal = $620,600 )
2020	2020	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	12	9/9/2020	COMPETING CONTINUATION	$620,600
														Subtotal = $620,600

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	11	7/11/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $637,768 )
2018	2018	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	11	5/10/2018	NON-COMPETING CONTINUATION	$637,768
														Subtotal = $637,768

Issue Date FY: 2017 ( Subtotal = $734,341 )
2017	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	002	10	7/4/2017	SUPPLEMENT FOR EXPANSION	$92,214
2017	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	10	5/9/2017	NON-COMPETING CONTINUATION	$472,670
2017	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	003	10	7/28/2017	NON-COMPETING CONTINUATION	$52,518
2017	2017	VIRGINIA COMMONWEALTH UNIVERSITY	912 W FRANKLIN ST	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	001	10	5/22/2017	SUPPLEMENT FOR EXPANSION	$116,939
														Subtotal = $734,341

Issue Date FY: 2016 ( Subtotal = $524,953 )
2016	2016	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	9	5/30/2016	NON-COMPETING CONTINUATION	$524,953
														Subtotal = $524,953

Issue Date FY: 2015 ( Subtotal = $514,637 )
2015	2015	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	8	5/12/2015	NON-COMPETING CONTINUATION	$514,637
														Subtotal = $514,637

Issue Date FY: 2014 ( Subtotal = $582,503 )
2014	2014	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	7	9/4/2014	COMPETING CONTINUATION	$582,503
2014	2014	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	001	7	9/5/2014	COMPETING CONTINUATION	$0
														Subtotal = $582,503

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2009	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	6	9/28/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $322,812 )
2010	2010	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	6	9/24/2010	SUPPLEMENT FOR EXPANSION	$322,812
														Subtotal = $322,812

Issue Date FY: 2009 ( Subtotal = $530,452 )
2009	2009	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	001	6	9/28/2009	SUPPLEMENT FOR EXPANSION	$339,725
2009	2009	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	6	9/1/2009	NON-COMPETING CONTINUATION	$190,727
														Subtotal = $530,452

Issue Date FY: 2008 ( Subtotal = $190,727 )
2008	2008	VIRGINIA COMMONWEALTH UNIVERSITY	327 WEST MAIN STREET	RICHMOND	VA	23284	RICHMOND CITY	USA	Alcohol Research Programs	000	5	8/27/2008	NON-COMPETING CONTINUATION	$190,727
														Subtotal = $190,727

Issue Date FY: 2007 ( Subtotal = $195,848 )
2007	2007	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Alcohol Research Programs	000	3	8/31/2007	NON-COMPETING CONTINUATION	$195,848
														Subtotal = $195,848

Issue Date FY: 2006 ( Subtotal = $201,697 ) (Continued on the next page)
Grand Total All Awards = $7,533,744

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The development of alcohol misuse and related problems from adolescence to early midlife

Award Number: R01AA015416

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2005

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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