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UCLA SPORE in Prostate Cancer

Award Number: P50CA092131
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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UCLA SPORE in Prostate Cancer - OVERALL SUMMARY/ABSTRACT The UCLA Prostate Cancer SPORE is a multidisciplinary and translational research program focused on the development of new and innovative approaches for improving the diagnosis, prognosis, and treatment of prostate cancer patients. The program’s reach includes collaborating investigators at local institutions such as Cedars Sinai and City of Hope in order to accelerate the goal of combating prostate cancer. A particular strength of the UCLA Prostate Cancer SPORE has been its ability to leverage institutional and NCI support to attract new human capital, technology, and ideas to the field of prostate cancer. Examples of these discoveries include: (1) the development of both the androgen receptor (AR) super-antagonists enzalutamide and apalutamide, (2) the discovery of the putative human prostate cancer stem cell of origin and its association with emergence of the lethal neuroendocrine phenotype, (3) the translation of novel engineered antibodies targeting Prostate Stem Cell Antigen (PSCA) to the clinic to target, treat and image prostate (and pancreatic) cancer, (4) the elucidation of signaling cross-talk between the PTEN/PI3K, AR, and ras/MAPK pathways in castrate resistant and treatment resistant prostate cancer (CRPC), and (5) the demonstration that a low fat diet supplemented with omega-3 fatty acids has measurable effects on prostate cancer and its mechanism of action. The overall goal of this competitive renewal application is to continue to apply the diversity of talent on the UCLA campus, its sister institutions and other institutions in Southern California to the critical and evolving translational challenges in the field of prostate cancer. To achieve the long-term objectives and goals of our program, the Specific Aims of the UCLA SPORE in Prostate Cancer are: (1) to perform high-impact translational research focused on some of the major challenges in the field of prostate cancer such as cancer metastasis, castration resistance, and treatment resistance, (2) to provide organizational infrastructure and novel technologies designed specifically to support the translational research objectives of the SPORE such as administrative, fiscal, and statistical support, and (3) to develop new prostate cancer researchers and research areas to advance translational research in prostate cancer through supporting innovative research in critical areas, pilot developmental research, and career development in prostate cancer research. Through these aims, UCLA Prostate Cancer SPORE can continue to promote significant and novel discoveries with potential major impact on men with prostate cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,599,812 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Centers Support Grants	000	20	9/15/2023	NON-COMPETING CONTINUATION	$1,599,812
														Subtotal = $1,599,812

Issue Date FY: 2022 ( Subtotal = $1,643,637 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Centers Support Grants	001	19	9/13/2022	NON-COMPETING CONTINUATION	$1,608,129
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Centers Support Grants	002	19	9/22/2022	NON-COMPETING CONTINUATION	$35,508
2022	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Centers Support Grants	000	18	7/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,643,637

Issue Date FY: 2021 ( Subtotal = $1,443,180 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Centers Support Grants	000	18	8/31/2021	NON-COMPETING CONTINUATION	$1,443,180
														Subtotal = $1,443,180

Issue Date FY: 2020 ( Subtotal = $1,449,094 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	003	17	8/25/2020	NON-COMPETING CONTINUATION	$1,449,094
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	002	16	4/16/2020	COMPETING CONTINUATION	$445,014
2020	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	16	1/29/2020	COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	001	15	4/16/2020	SUPPLEMENT FOR EXPANSION	-$445,014
														Subtotal = $1,449,094

Issue Date FY: 2019 ( Subtotal = $1,708,652 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	001	16	8/22/2019	COMPETING CONTINUATION	$1,708,652
2019	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	15	11/30/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,708,652

Issue Date FY: 2018 ( Subtotal = $1,162,609 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	15	9/19/2018	SUPPLEMENT FOR EXPANSION	$1,162,609
														Subtotal = $1,162,609

Issue Date FY: 2017 ( Subtotal = $2,300,000 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	003	15	9/21/2017	NON-COMPETING CONTINUATION	$115,000
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	002	15	8/9/2017	NON-COMPETING CONTINUATION	$2,185,000
2017	2016	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	001	14	6/29/2017	EXTENSION WITH OR WITHOUT FUNDS	$19,201
2017	2015	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	13	6/29/2017	NON-COMPETING CONTINUATION	-$19,201
														Subtotal = $2,300,000

Issue Date FY: 2016 ( Subtotal = $2,257,312 )
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	001	14	8/31/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,157,312
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Treatment Research	000	13	5/9/2016	SUPPLEMENT FOR EXPANSION	$100,000
														Subtotal = $2,257,312

Issue Date FY: 2015 ( Subtotal = $2,185,000 )
2015	2015	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	13	8/24/2015	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2014 ( Subtotal = $2,162,000 )
2014	2014	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	12	9/9/2014	NON-COMPETING CONTINUATION	$2,162,000
														Subtotal = $2,162,000

Issue Date FY: 2013 ( Subtotal = $2,150,500 )
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	11	9/18/2013	COMPETING CONTINUATION	$2,150,500
														Subtotal = $2,150,500

Issue Date FY: 2011 ( Subtotal = $2,185,000 )
2011	2011	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	10	6/28/2011	NON-COMPETING CONTINUATION	$2,185,000
														Subtotal = $2,185,000

Issue Date FY: 2010 ( Subtotal = $2,300,000 )
2010	2010	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	001	9	6/16/2010	NON-COMPETING CONTINUATION	$2,300,000
2010	2009	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	8	10/29/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,300,000

Issue Date FY: 2009 ( Subtotal = $2,348,217 )
2009	2009	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	8	6/22/2009	NON-COMPETING CONTINUATION	$2,348,217
														Subtotal = $2,348,217

Issue Date FY: 2008 ( Subtotal = $2,346,813 )
2008	2008	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Cancer Centers Support Grants	000	7	8/22/2008	NON-COMPETING CONTINUATION	$2,346,813
														Subtotal = $2,346,813

Issue Date FY: 2007 ( Subtotal = $2,345,450 )
2007	2007	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Centers Support Grants	000	6	8/15/2007	COMPETING CONTINUATION	$2,345,450
														Subtotal = $2,345,450

Issue Date FY: 2006 ( Subtotal = $2,259,694 )
2006	2006	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Control	000	5	8/7/2006	NON-COMPETING CONTINUATION	$2,259,694
														Subtotal = $2,259,694

Issue Date FY: 2005 ( Subtotal = $2,314,075 )
2005	2005	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Control	000	4	7/1/2005	NON-COMPETING CONTINUATION	$2,314,075
														Subtotal = $2,314,075

Issue Date FY: 2004 ( Subtotal = $2,272,341 )
2004	2004	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cancer Control	000	3	8/16/2004	NON-COMPETING CONTINUATION	$2,272,341
														Subtotal = $2,272,341

Issue Date FY: 2003 ( Subtotal = $2,272,378 ) (Continued on the next page)
Grand Total All Awards = $42,593,965

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UCLA SPORE in Prostate Cancer

Award Number: P50CA092131

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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