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Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation

Award Number: P42ES010356
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Research conducted within the Duke University’s Superfund Research Center (DUSRC) will study neurodevelopmental health impacts of early-life co-exposures to PAHs and metals. Metals (particularly Pb) and PAHs are among the top 10 contaminants identified at both Superfund and Brownfield sites, and they often co- occur. Therefore, exposure to mixtures of these contaminants is very common. And unfortunately, the communities that are often more impacted by these exposures are people of color, which can further contribute to the growing health disparities in the United States. Despite their co-occurrence, evaluations of their risks typically neglect the impacts of co-exposures. As a result, site management strategies often try to discretize the multi-contaminant problem, leading to remediation targets that are based on health risks associated with a single exposure rather than real-world mixtures. Our overarching goal within the DUSRC is to investigate co-exposures that “replicate the human experience”, as described by NIEHS’s Strategic Plan to advance environmental health science. More specifically, our Center will study the impacts of multiple contaminant exposures in humans and ecological models of neurodevelopmental health, elucidate neurotoxic mechanisms that occur from these co- exposures, and develop remediation and treatment strategies that target the highest risk contaminants without increasing the risk of other contaminants. This integration is central to evaluating the true risk from exposure to hazardous substances. The DUSRC directly addresses the program mandates by investigating health effects and risks and remediation of hazardous substances in an interdisciplinary fashion. Our interdisciplinary team of toxicologists, exposure scientists, environmental chemists, engineers, epidemiologists, and community based environmental managers, provide the DUSRC with a unique opportunity to address and examine this complex problem using a systems approach. In addition to responding to SRP mandates, the DUSRC’s research, research translation, and community engagement activities are also highly relevant to numerous stakeholders at the local, regional and federal levels. Our work will provide key data and information needed to address several problems relevant for the Superfund Research program.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,296,459 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	22	6/27/2024	NON-COMPETING CONTINUATION	$2,296,459
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	21	7/17/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,296,459

Issue Date FY: 2023 ( Subtotal = $2,387,039 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	21	6/23/2023	NON-COMPETING CONTINUATION	$2,337,139
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	21	6/30/2023	SUPPLEMENT FOR EXPANSION	$49,900
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	20	3/13/2023	COMPETING CONTINUATION	$762,946
2023	2021	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	19	3/13/2023	NON-COMPETING CONTINUATION	-$762,946
														Subtotal = $2,387,039

Issue Date FY: 2022 ( Subtotal = $2,339,292 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	20	9/6/2022	COMPETING CONTINUATION	$2,339,292
														Subtotal = $2,339,292

Issue Date FY: 2021 ( Subtotal = $2,276,937 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	19	3/26/2021	NON-COMPETING CONTINUATION	$2,276,937
2021	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	12/31/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,276,937

Issue Date FY: 2020 ( Subtotal = $2,131,879 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	18	4/13/2020	NON-COMPETING CONTINUATION	$2,029,229
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Environmental Health	003	18	5/31/2020	SUPPLEMENT FOR EXPANSION	$92,660
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	18	6/30/2020	SUPPLEMENT FOR EXPANSION	$9,990
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	17	2/6/2020	NON-COMPETING CONTINUATION	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	17	2/7/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,131,879

Issue Date FY: 2019 ( Subtotal = $2,651,165 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	17	9/12/2019	SUPPLEMENT FOR EXPANSION	$599,438
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	17	6/4/2019	NON-COMPETING CONTINUATION	$2,051,727
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	007	17	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	4/9/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	16	4/9/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	16	6/25/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	16	6/25/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	16	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,651,165

Issue Date FY: 2018 ( Subtotal = $2,438,347 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	16	8/31/2018	SUPPLEMENT FOR EXPANSION	$400,000
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	16	3/22/2018	NON-COMPETING CONTINUATION	$2,027,639
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	5/3/2018	SUPPLEMENT FOR EXPANSION	$10,708
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	16	9/3/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,438,347

Issue Date FY: 2017 ( Subtotal = $2,033,248 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	009	15	9/13/2017	COMPETING CONTINUATION	$720,718
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	007	15	8/9/2017	COMPETING CONTINUATION	$2,033,248
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	15	8/4/2017	COMPETING CONTINUATION	-$2,033,248
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	010	15	9/28/2017	COMPETING CONTINUATION	$12,809
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	6/30/2017	COMPETING CONTINUATION	$2,033,248
2017	2016	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	011	14	9/28/2017	SUPPLEMENT FOR EXPANSION	-$12,809
2017	2016	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	008	14	9/13/2017	SUPPLEMENT FOR EXPANSION	-$720,718
2017	2016	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	14	8/1/2017	SUPPLEMENT FOR EXPANSION	$234,239
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	14	8/1/2017	SUPPLEMENT FOR EXPANSION	-$7,000
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	14	8/1/2017	SUPPLEMENT FOR EXPANSION	-$68,907
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	14	8/1/2017	SUPPLEMENT FOR EXPANSION	-$9,288
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	14	8/1/2017	NON-COMPETING CONTINUATION	-$149,044
														Subtotal = $2,033,248

Issue Date FY: 2016 ( Subtotal = $2,320,270 ) (Continued on the next page)
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	14	8/15/2016	SUPPLEMENT FOR EXPANSION	$2,042,517
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	14	1/27/2016	SUPPLEMENT FOR EXPANSION	$27,557
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	14	9/21/2016	SUPPLEMENT FOR EXPANSION	$250,196
Grand Total All Awards = $48,865,213

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Duke University Superfund Research Center - Developmental Co-Exposures: Mechanisms, Outcomes, and Remediation

Award Number: P42ES010356

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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