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Duke University Superfund Research Center - Developmental Exposures: Mechanisms, Outcomes and Remediation

Award Number: P42ES010356
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Research conducted within the Duke University’s Superfund Research Center (DUSRC) focuses on a central research question: How does early life exposure to hazardous substances elicit developmental toxicity, and what are the later-life consequences? As such the theme of our center is “Developmental Exposures: Mechanisms, Consequences and Remediation”, and we remain committed to investigating the vulnerability of the developing organism to hazardous chemical exposures. Within the DUSRC we emphasize research on both ATSDR priority chemicals (e.g. PAHs, metals, organophosphate chemicals) and emerging chemicals of concern (e.g. halogenated flame retardants) that are known to, or have potential to, adversely effect development. Mechanisms of action that are central to the mission and research conducted within the DUSRC include mechanisms underlying molecular and physiological effects from developmental exposures, mechanisms underlying ameliorations of and adaptations to these effects, and mechanisms and approaches to engineering solutions for the ultimate removal of these chemicals from the environment. A unifying theme across the DUSRC projects is effects on neurobehavioral and neurodevelopmental outcomes from these exposures. DUSRC researchers are conducting research using in vitro (e.g. cell culture) and in vivo (e.g. zebrafish, rats) models to determine effects of these hazardous chemicals on neurodevelopmental across projects, but several individual projects are also exploring effects on skeletal and fat development, cardiovascular development and bioenergetics. Of key interest is the ability of some contaminants to converge on similar phenotypes through multiple mechanisms of action. With the heightened interest in developing Adverse Outcome Pathways (AOPs) within regulatory agencies, the DUSRC is well poised to support these endeavors. Our interdisciplinary team of biomedical/environmental scientists and engineers provide the DUSRC with a unique opportunity to address and examine “holistic” consequences of developmental exposures. This integration is central to evaluating the true risk from exposure to hazardous substances. The DUSRC directly addresses the program mandates by investigating health effects and risks and remediation of hazardous substances in an interdisciplinary fashion. In addition to responding to SRP mandates, the DUSRC’s research, research translation, and community engagement activities are also highly relevant to numerous stakeholders, including the Environmental Protection Agency.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,296,459 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	22	6/27/2024	NON-COMPETING CONTINUATION	$2,296,459
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	21	7/17/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,296,459

Issue Date FY: 2023 ( Subtotal = $2,387,039 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	21	6/23/2023	NON-COMPETING CONTINUATION	$2,337,139
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	21	6/30/2023	SUPPLEMENT FOR EXPANSION	$49,900
2023	2022	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	20	3/13/2023	COMPETING CONTINUATION	$762,946
2023	2021	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	19	3/13/2023	NON-COMPETING CONTINUATION	-$762,946
														Subtotal = $2,387,039

Issue Date FY: 2022 ( Subtotal = $2,339,292 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	20	9/6/2022	COMPETING CONTINUATION	$2,339,292
														Subtotal = $2,339,292

Issue Date FY: 2021 ( Subtotal = $2,276,937 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	19	3/26/2021	NON-COMPETING CONTINUATION	$2,276,937
2021	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	18	12/31/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,276,937

Issue Date FY: 2020 ( Subtotal = $2,131,879 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	18	4/13/2020	NON-COMPETING CONTINUATION	$2,029,229
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Environmental Health	003	18	5/31/2020	SUPPLEMENT FOR EXPANSION	$92,660
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	18	6/30/2020	SUPPLEMENT FOR EXPANSION	$9,990
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	17	2/6/2020	NON-COMPETING CONTINUATION	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	17	2/7/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,131,879

Issue Date FY: 2019 ( Subtotal = $2,651,165 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	17	9/12/2019	SUPPLEMENT FOR EXPANSION	$599,438
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	17	6/4/2019	NON-COMPETING CONTINUATION	$2,051,727
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	007	17	9/19/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	4/9/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	16	4/9/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	16	6/25/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	16	6/25/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	16	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,651,165

Issue Date FY: 2018 ( Subtotal = $2,438,347 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	16	8/31/2018	SUPPLEMENT FOR EXPANSION	$400,000
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	16	3/22/2018	NON-COMPETING CONTINUATION	$2,027,639
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	16	5/3/2018	SUPPLEMENT FOR EXPANSION	$10,708
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	16	9/3/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,438,347

Issue Date FY: 2017 ( Subtotal = $2,033,248 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	009	15	9/13/2017	COMPETING CONTINUATION	$720,718
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	007	15	8/9/2017	COMPETING CONTINUATION	$2,033,248
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	006	15	8/4/2017	COMPETING CONTINUATION	-$2,033,248
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	010	15	9/28/2017	COMPETING CONTINUATION	$12,809
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	15	6/30/2017	COMPETING CONTINUATION	$2,033,248
2017	2016	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	011	14	9/28/2017	SUPPLEMENT FOR EXPANSION	-$12,809
2017	2016	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	008	14	9/13/2017	SUPPLEMENT FOR EXPANSION	-$720,718
2017	2016	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	005	14	8/1/2017	SUPPLEMENT FOR EXPANSION	$234,239
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	004	14	8/1/2017	SUPPLEMENT FOR EXPANSION	-$7,000
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	14	8/1/2017	SUPPLEMENT FOR EXPANSION	-$68,907
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	14	8/1/2017	SUPPLEMENT FOR EXPANSION	-$9,288
2017	2015	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	001	14	8/1/2017	NON-COMPETING CONTINUATION	-$149,044
														Subtotal = $2,033,248

Issue Date FY: 2016 ( Subtotal = $2,320,270 ) (Continued on the next page)
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	002	14	8/15/2016	SUPPLEMENT FOR EXPANSION	$2,042,517
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	000	14	1/27/2016	SUPPLEMENT FOR EXPANSION	$27,557
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	NIEHS Superfund Hazardous Substances_Basic Research and Education	003	14	9/21/2016	SUPPLEMENT FOR EXPANSION	$250,196
Grand Total All Awards = $48,865,213

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Duke University Superfund Research Center - Developmental Exposures: Mechanisms, Outcomes and Remediation

Award Number: P42ES010356

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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