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National Resource for Automated Molecular Microscopy

Award Number: P41GM103310
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2002
PERIOD OF PERFORMANCE END DATE: 03/31/2023

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National Resource for Automated Molecular Microscopy - 1. Overall: The National Resource for Automated Molecular Microscopy Abstract The overall mission of the National Resource for Automated Molecular Microscopy (NRAMM) is to develop, test and apply technology aimed at automating and streamlining cryo-electron microscopy (cryoEM) for structural biology. Our goal from the outset was to provide a pipeline for molecular microscopy that puts it on a par with other structural techniques like X-ray crystallography, so that, once suitable samples are in hand, getting to a high resolution 3D map is a straightforward and rapid undertaking. This one time dream is now obtainable for well-behaved samples as a result of many innovations and improvements in hardware and software, including most recently the advent of a new generation of cameras that directly detect electrons and record high frame rate movies allowing for correction of sample movement during image exposure. There is still work to be done however in ensuring that this method can be applied to the most challenging and biologically interesting samples and serve a very large influx of new practitioners of this method. Our Technology Research and Development (TRD) Projects for the next five years are designed to meet the challenges. Our goals are to develop novel approaches and promote their widespread use, as well as to integrate complex technologies into an efficient and effective method. To achieve these goals, we will focus on three Technological Research and Development Projects that encompass both completely new approaches as well as dynamic evolution of our current technologies. In TRD#1, we will seek to address the critical need to improve and automate vitrified sample preparation; develop methods for time resolved vitrification; and greatly accelerate the throughput of negatively stained sample screening. In TRD#2, we will continue to optimize the performance of both high and mid-range instruments, particularly with regard to integrating and assessing the value of several major accessories; we will develop a high-throughput data acquisition pipeline to support negative stain screening; and we will continue to develop enabling tools for data assessment, processing, analysis and reconstruction. Finally, in TRD#3 we will embark on the development of a new automated and streamlined pipeline for support of in-situ molecular microscopy, that is visualizing molecular structures inside cells. The technological themes at the heart of this proposal support our mission of providing an automated and streamlined pipeline for molecular microscopy that provides data of the highest possible quality and promotes the accessibility of the method to the wider scientific community. This mission is driven by close interactions and feedback from Driving Biological projects (DBPs), and further tested and validated by Collaborative and Service Projects (CSPs). We will also continue to work to maintain excellence in the areas of training and dissemination to promote the broadest possible use of these technologies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC.	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	21	12/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	21	1/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	21	10/20/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,344,865 )
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	21	3/25/2021	NON-COMPETING CONTINUATION	$1,344,865
2021	2021	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	21	8/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,344,865

Issue Date FY: 2020 ( Subtotal = $1,344,865 )
2020	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	20	4/1/2020	NON-COMPETING CONTINUATION	$1,344,865
2020	2020	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	20	9/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,344,865

Issue Date FY: 2019 ( Subtotal = $1,978,469 )
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	19	8/6/2019	SUPPLEMENT FOR EXPANSION	$633,604
2019	2019	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	19	4/2/2019	NON-COMPETING CONTINUATION	$1,344,865
														Subtotal = $1,978,469

Issue Date FY: 2018 ( Subtotal = $1,440,064 )
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	003	18	7/27/2018	SUPPLEMENT FOR EXPANSION	$95,200
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	002	18	6/4/2018	NON-COMPETING CONTINUATION	$134,486
2018	2018	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	18	3/26/2018	NON-COMPETING CONTINUATION	$1,210,379
2018	2016	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	16	11/11/2017	NON-COMPETING CONTINUATION	-$1
														Subtotal = $1,440,064

Issue Date FY: 2017 ( Subtotal = $1,879,865 )
2017	2017	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	17	6/1/2017	COMPETING CONTINUATION	$1,879,865
2017	2016	NEW YORK STRUCTURAL BIOLOGY CENTER, INC., THE	89 CONVENT AVE	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	16	5/31/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,879,865

Issue Date FY: 2016 ( Subtotal = $1,233,858 )
2016	2016	NEW YORK STRUCTURAL BIOLOGY CENTER	89 CONVENT AVE PARK BLDG	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	000	16	3/22/2016	NON-COMPETING CONTINUATION	$1,233,858
														Subtotal = $1,233,858

Issue Date FY: 2015 ( Subtotal = $1,135,292 )
2015	2015	NEW YORK STRUCTURAL BIOLOGY CENTER	89 CONVENT AVE PARK BLDG	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	002	15	3/10/2015	NON-COMPETING CONTINUATION	$1,118,166
2015	2014	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	13	1/29/2015	NON-COMPETING CONTINUATION	-$315,993
2015	2014	NEW YORK STRUCTURAL BIOLOGY CENTER	89 CONVENT AVE PARK BLDG	NEW YORK	NY	10027	NEW YORK	USA	Biomedical Research and Research Training	001	14	1/30/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$333,119
														Subtotal = $1,135,292

Issue Date FY: 2014 ( Subtotal = $1,334,578 )
2014	2014	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	13	3/27/2014	NON-COMPETING CONTINUATION	$1,334,578
														Subtotal = $1,334,578

Issue Date FY: 2013 ( Subtotal = $1,348,172 )
2013	2013	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	002	12	8/15/2013	SUPPLEMENT FOR EXPANSION	$70,229
2013	2013	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	12	5/31/2013	NON-COMPETING CONTINUATION	$85,998
2013	2013	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	12	3/14/2013	NON-COMPETING CONTINUATION	$1,191,945
														Subtotal = $1,348,172

Issue Date FY: 2012 ( Subtotal = $1,700,776 )
2012	2012	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	000	11	4/6/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,542,025
2012	2012	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Biomedical Research and Research Training	001	11	8/1/2012	SUPPLEMENT FOR EXPANSION	$158,751
														Subtotal = $1,700,776

Grand Total All Awards = $14,740,804

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National Resource for Automated Molecular Microscopy

Award Number: P41GM103310

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2002

PERIOD OF PERFORMANCE END DATE: 03/31/2023

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