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Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function

Award Number: P30GM145497
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function - Chronic pain continues to be a critical health, social and economic issue throughout the world. Patient relief is undermined by modest efficacy and/or serious, self-limiting side effects of all current pain pharmaceuticals. Moreover, the opioid epidemic, that has only increased in severity as a consequence of COVID-19, lends urgency to the search for alternative treatments for moderate to severe pain. Through Phase 1 and 2 COBRE funding and leveraged institutional support, the University of New England (UNE) Center for the Study of Pain and Sensory Function was successful in renovating new laboratory space, establishing two research core facilities, and recruiting a critical mass of investigators studying pain and its treatment. Provided with mentorship and career development support, research project funding, and access to state-of-the-art research core facilities, COBRE investigators have made major scientific advances in the discovery of novel targets for the treatment of chronic pain and secured almost $14 million in extramural research funding. The research cores have already supported SBIR and STTR projects that have led to the submission of one compound to the FDA for approval of Phase 1 clinical trials. This increase in research activity seeded by COBRE funds was largely responsible for UNE’s recent promotion to R2 status (denoted as high research activity) by the Carnegie Classification of Institutions of Higher Education. COBRE Phase 3 will build on its previous successes to secure the Center’s long-term viability. Strong institutional support will continue to be provided in the form of dedicated core space, equipment maintenance, internal funding for a research core voucher program, release time for core Directors and guarantee of core staff salary beyond Phase 3. For Aim 1, the COBRE team will continue to increase research capacity through career development programming and direct financial support for pilot research projects. The Pilot Project Program will accept applications from faculty at UNE and regional partner institutions to support projects that utilize the core facilities and have the potential to lead to extramural funding. This approach will increase the research core user base and assist in Aim 2, transitioning the research cores into sustainable resources that provide expertise, training, and state- of-the-art instrumentation to the UNE and broader scientific communities for conducting cutting-edge biomedical research. The research cores will become sustainable through collaborations with regional COBREs and Maine INBRE partners, the combined efforts of the External Advisory and Steering Committees, strong institutional support, and an aggressive business strategic planning and marketing approach. COBRE Phases 1 and 2 profoundly transformed the research environment at UNE. At the time of Phase 1 submission, core research facilities were nonexistent. The increase in research capacity created through the COBRE program has led to the recruitment and funding of a critical mass of investigators, training of a skilled workforce, and development of sustainable core research facilities that can support high-quality research for UNE faculty and students, as well as external academic and industry partners. With continued institutional investment and additional support provided through Phase 3 funding, we will build on this early success and establish our center as a leader in pain research for many years to come.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,064,953 )
2026	2026	UNIVERSITY OF NEW ENGLAND	11 HILLS BEACH RD	BIDDEFORD	ME	04005	YORK	USA	Biomedical Research and Research Training	001	5	5/26/2026	NON-COMPETING CONTINUATION	$1,064,953
2026	2025	UNIVERSITY OF NEW ENGLAND	11 HILLS BEACH RD	BIDDEFORD	ME	04005	YORK	USA	Biomedical Research and Research Training	000	4	1/20/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,064,953

Issue Date FY: 2025 ( Subtotal = $1,064,953 )
2025	2025	UNIVERSITY OF NEW ENGLAND	11 HILLS BEACH RD	BIDDEFORD	ME	04005	YORK	USA	Biomedical Research and Research Training	000	4	8/6/2025	NON-COMPETING CONTINUATION	$1,064,953
														Subtotal = $1,064,953

Issue Date FY: 2024 ( Subtotal = $1,314,953 )
2024	2024	UNIVERSITY OF NEW ENGLAND	11 HILLS BEACH RD	BIDDEFORD	ME	04005	YORK	USA	Biomedical Research and Research Training	000	3	5/16/2024	NON-COMPETING CONTINUATION	$1,064,953
2024	2024	UNIVERSITY OF NEW ENGLAND	11 HILLS BEACH RD	BIDDEFORD	ME	04005	YORK	USA	Biomedical Research and Research Training	001	3	5/23/2024	SUPPLEMENT FOR EXPANSION	$250,000
														Subtotal = $1,314,953

Issue Date FY: 2023 ( Subtotal = $1,064,953 )
2023	2023	UNIVERSITY OF NEW ENGLAND	11 HILLS BEACH RD	BIDDEFORD	ME	04005	YORK	USA	Biomedical Research and Research Training	000	2	5/22/2023	NON-COMPETING CONTINUATION	$1,064,953
														Subtotal = $1,064,953

Issue Date FY: 2022 ( Subtotal = $1,041,311 )
2022	2022	UNIVERSITY OF NEW ENGLAND	11 HILLS BEACH RD	BIDDEFORD	ME	04005	YORK	USA	Biomedical Research and Research Training	000	1	5/31/2022	NEW	$1,041,311
														Subtotal = $1,041,311

Grand Total All Awards = $5,551,123

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Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function

Award Number: P30GM145497

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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