Wednesday, July 2, 2025 7/2/2025

Hepatobiology and Toxicology COBRE

Award Number: P20GM113226
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/10/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2026

Group Awards By:

View Award Description

Hepatobiology and Toxicology COBRE - The University of Louisville (UofL) Hepatobiology and Toxicology (H&T) COBRE is a unique thematic center focused on liver research. The UofL H&T COBRE concentrates on the mechanisms and therapeutic strategies for multiple forms of liver disease/injury, including: Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis—the most common liver disease in the US/worldwide, and is highly linked to the metabolic syndrome; Alcoholic Liver Disease—a common problem among those who drink; Environmental Toxicant Induced Liver Injury—an increasingly recognized problem, and Louisville has been a leader in this area; Hepatitis B and C—important causes of cirrhosis and hepatocellular carcinoma worldwide; Personalized Medicine—an increasingly important factor in medication efficacy, and most drugs are metabolized in the liver; and Drug-Induced Liver Injury—the most common reason drugs are removed from the market and an important cause of liver failure. This COBRE brings together experienced senior mentors/investigators and promising junior investigators to perform cross-cutting research on the unique topics of Hepatobiology and Toxicology. We address critical barriers in our understanding of the development/ progression of liver disease and we define targets for prevention/treatment that could transform clinical practice. Specific Aims of the Hepatobiology and Toxicology COBRE are to: 1. Expand and strengthen a thematically-focused program in Hepatobiology and Toxicology that helps build and sustain the overall research infrastructure at UofL. 2. Expand and strengthen the multidisciplinary program in research education, mentoring and career development in Hepatobiology and Toxicology, and systematically track and evaluate the progress. 3. Provide the necessary research resources and translational science/basic technologies to support state-of- the-art research in Hepatobiology and Toxicology and to ensure sustainability of the program. 4. Discover new mechanisms/molecular targets and effective means for preventing and/or treating liver diseases/toxicant exposures and communicate our findings to the public. In summary, Phase I strengthened UofL’s biomedical research infrastructure through the establishment of a thematic multidisciplinary center in hepatobiology and toxicology to enhance the ability of investigators to compete for independent funding. In Phase I, we met or exceeded our metrics, including 1) four of our investigators transitioning to independent research funding; 2) 91 mentee and 162 total publications; 3) new renovated laboratory space; 4) numerous presentations; 5) establishing new collaborations; and 6) >$75 million in total new grant funding by H&T members. This Phase II proposal builds on our Phase I success, extends and strengthens the scope of the program, and provides a roadmap for sustainability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,197,056 )
2025	2025	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	10	5/28/2025	NON-COMPETING CONTINUATION	$2,197,056
														Subtotal = $2,197,056

Issue Date FY: 2024 ( Subtotal = $2,236,038 )
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	001	9	5/17/2024	NON-COMPETING CONTINUATION	$223,604
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	9	3/20/2024	NON-COMPETING CONTINUATION	$2,012,434
														Subtotal = $2,236,038

Issue Date FY: 2023 ( Subtotal = $2,524,291 )
2023	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	004	8	5/19/2023	NON-COMPETING CONTINUATION	$2,274,291
2023	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	005	8	7/4/2023	SUPPLEMENT FOR EXPANSION	$250,000
2023	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	003	6	4/3/2023	COMPETING CONTINUATION	$94,996
2023	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	001	6	11/14/2022	COMPETING CONTINUATION	-$510,130
2023	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	5	11/14/2022	NON-COMPETING CONTINUATION	$510,130
2023	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	002	5	3/9/2023	NON-COMPETING CONTINUATION	-$94,996
														Subtotal = $2,524,291

Issue Date FY: 2022 ( Subtotal = $3,316,596 )
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	003	7	5/16/2022	NON-COMPETING CONTINUATION	$230,960
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	005	7	8/25/2022	SUPPLEMENT FOR EXPANSION	$939,000
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	002	7	4/11/2022	NON-COMPETING CONTINUATION	$2,078,636
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	004	7	8/10/2022	SUPPLEMENT FOR EXPANSION	$68,000
2022	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	001	6	11/13/2021	COMPETING CONTINUATION	$510,130
2022	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	5	11/13/2021	NON-COMPETING CONTINUATION	-$510,130
														Subtotal = $3,316,596

Issue Date FY: 2021 ( Subtotal = $2,590,000 )
2021	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	002	6	8/19/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	001	6	3/25/2021	COMPETING CONTINUATION	$2,340,000
2021	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	5	3/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,590,000

Issue Date FY: 2020 ( Subtotal = $2,180,726 )
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	5	3/9/2020	NON-COMPETING CONTINUATION	$2,180,726
														Subtotal = $2,180,726

Issue Date FY: 2019 ( Subtotal = $2,214,500 )
2019	2019	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	001	4	4/1/2019	NON-COMPETING CONTINUATION	$2,214,500
2019	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	3	3/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,214,500

Issue Date FY: 2018 ( Subtotal = $1,912,971 )
2018	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	3	3/26/2018	NON-COMPETING CONTINUATION	$1,688,243
2018	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	001	3	4/27/2018	NON-COMPETING CONTINUATION	$224,728
2018	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	002	3	8/1/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,912,971

Issue Date FY: 2017 ( Subtotal = $2,279,140 )
2017	2017	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	001	2	7/11/2017	NON-COMPETING CONTINUATION	$227,914
2017	2017	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Biomedical Research and Research Training	000	2	3/31/2017	NON-COMPETING CONTINUATION	$2,051,226
														Subtotal = $2,279,140

Issue Date FY: 2016 ( Subtotal = $2,608,500 )
2016	2016	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Biomedical Research and Research Training	000	1	6/9/2016	NEW	$2,608,500
														Subtotal = $2,608,500

Grand Total All Awards = $24,059,818

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Hepatobiology and Toxicology COBRE

Award Number: P20GM113226

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/10/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer