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Nebraska Center for Integrated Biomolecular Communication (CIBC)

Award Number: P20GM113126
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Nebraska Center for Integrated Biomolecular Communication (CIBC) - PROJECT SUMMARY/ABSTRACT Regulation of biomolecular communication pathways is critical to maintaining physiological function. Unraveling these pathways and filling in critical knowledge gaps will provide novel opportunities to understand, diagnose, and treat human diseases. During Phase 1, the Nebraska Center for Integrated Biomolecular Communication (CIBC) supported 15 early stage investigators (ESIs), helped recruit four new faculty members to the University of Nebraska-Lincoln (UNL), and established two research cores. CIBC’s ESIs secured $16.7 million in external research funds and authored 82 peer-reviewed publications. Building on Phase 1, the goal of the CIBC in Phase 2 is to continue building a critical mass of biomedical investigators and supporting research infrastructure in the area of biomolecular communication pathways at UNL that will position CIBC for a successful transition to long- term sustainability in Phase 3. CIBC will continue to develop multidisciplinary teams to interrogate complex disease pathways, especially by connecting researchers developing new molecular probes and analytical techniques with those unravelling molecular mechanisms of human diseases. CIBC’s Phase 2 specific aims are to: 1) strengthen UNL’s biomedical research infrastructure by supporting the research efforts and career development of biomedical investigators whose research is broadly focused on understanding the regulation of biomedically relevant communication pathways; 2) enhance research capabilities by maintaining and expanding the Systems Biology Core (SBC) to facilitate acquisition of essential bioanalytical data and the Data and Life Sciences Core (DLSC) to provide critical bioinformatics support and data management, storage, and sharing to Center members; and 3) advance interdisciplinary research collaborations with broad disciplinary representation to pursue high-impact research into complex disease from diverse perspectives. The initial Phase 2 Project Leaders will pursue projects interrelated by their fundamental focus on different aspects of the biomolecular basis of disease-associated communication pathways. These projects, which signify CIBC’s interdisciplinary nature, are directed toward: 1) developing novel chemical probes and targeted mass spectrometry approaches to study the cocaine and amphetamine-regulated transcript peptide and receptor(s), 2) understanding how the 7SK RNP regulates transcription and its implications in human diseases, 3) conducting near real-time detection of methicillin-resistant S. aureus by developing a generalizable electrochemical peptide-based biosensing platform, and 4) developing a novel Unnatural Amino Acid-based Chromatin Isolation Method (UChIMe) with improved accuracy and sensitivity. CIBC will further expand SBC and DLSC to enable Nebraska’s biomedical researchers to pursue high-impact biomedical research. CIBC’s innovation is in integrating the research activities of chemists, biochemists, engineers, and bioinformaticians to understand how cells communicate and integrate metabolic and regulatory pathways relevant to disease development and progression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	9	11/7/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,319,707 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST # 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	9	9/18/2024	NON-COMPETING CONTINUATION	$2,319,707
														Subtotal = $2,319,707

Issue Date FY: 2023 ( Subtotal = $2,319,707 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	8	8/25/2023	NON-COMPETING CONTINUATION	$2,319,707
2023	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	7	3/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,319,707

Issue Date FY: 2022 ( Subtotal = $2,244,875 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	005	7	9/13/2022	NON-COMPETING CONTINUATION	$2,244,875
2022	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	003	6	2/14/2022	COMPETING CONTINUATION	$2,624,906
2022	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	004	6	2/23/2022	COMPETING CONTINUATION	$0
2022	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	002	5	2/14/2022	SUPPLEMENT FOR EXPANSION	-$249,995
2022	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	5	2/14/2022	NON-COMPETING CONTINUATION	-$2,281,338
2022	2019	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	2/14/2022	NON-COMPETING CONTINUATION	-$93,573
														Subtotal = $2,244,875

Issue Date FY: 2021 ( Subtotal = $1,452,608 )
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	003	6	9/24/2021	COMPETING CONTINUATION	$378,875
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	002	6	9/14/2021	COMPETING CONTINUATION	$1,073,733
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	5	7/16/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	5	9/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,452,608

Issue Date FY: 2020 ( Subtotal = $2,531,333 )
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	002	5	8/11/2020	SUPPLEMENT FOR EXPANSION	$249,995
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	5	8/10/2020	NON-COMPETING CONTINUATION	$2,281,338
2020	2019	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	7/9/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,531,333

Issue Date FY: 2019 ( Subtotal = $2,281,340 )
2019	2019	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	4	9/11/2019	NON-COMPETING CONTINUATION	$2,281,340
														Subtotal = $2,281,340

Issue Date FY: 2018 ( Subtotal = $2,012,250 )
2018	2018	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	001	3	9/19/2018	NON-COMPETING CONTINUATION	$0
2018	2018	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	3	9/10/2018	NON-COMPETING CONTINUATION	$2,012,250
														Subtotal = $2,012,250

Issue Date FY: 2017 ( Subtotal = $2,250,619 )
2017	2017	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	2200 VINE ST BOX 830861	LINCOLN	NE	68503	LANCASTER	USA	Biomedical Research and Research Training	000	2	9/15/2017	NON-COMPETING CONTINUATION	$2,250,619
														Subtotal = $2,250,619

Issue Date FY: 2016 ( Subtotal = $2,212,782 )
2016	2016	UNIVERSITY OF NEBRASKA LINCOLN	303 ADMINISTRATION BUILDING	LINCOLN	NE	68588	LANCASTER	USA	Biomedical Research and Research Training	000	1	8/10/2016	NEW	$2,212,782
														Subtotal = $2,212,782

Grand Total All Awards = $19,625,221

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Nebraska Center for Integrated Biomolecular Communication (CIBC)

Award Number: P20GM113126

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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