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Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

Award Number: P20GM109024
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer - PROJECT SUMMARY Although the survival for other cancers improved during the last ten years, the outlook for pancreatic ductal adenocarcinoma (PDAC) remains grim. The average overall 5-year survival rate for PDAC is 10.8%. The mission of the Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer (CDTSPC) in Phase II is to enhance and sustain biomedical research infrastructure at North Dakota State University (NDSU) by developing externally-funded, independent translational research of the Junior Investigators, expanding Core Facility services, and recruiting new investigators. The Covid pandemic-related restrictions hampered our progress in Phase I. Still, the investigators received seven nationally competitive research grants totaling $9.6 million, published more than 50 papers, and graduated 17 Ph. D. students. Two Junior Investigators and three pilot project leaders received tenure and promotion. NDSU hired four new Assistant Professors with research emphasis on pancreatic cancer. Two new Core Facilities were set up – Animal Studies and Biostatistics. The two facilities served 19 COBRE and 33 other investigators. The Animal Core Facility created comprehensive mice models for the first time on campus, including 7 patient-derived mouse models (PDX) of pancreatic cancer. CDTSPC is the only established Facility in North Dakota with the capacity to support foundational and translational research on pancreatic cancer. In Phase II, we will further expand the biomedical infrastructure, emphasizing translational research and prepare for a self-sustaining Center through the following Specific Aims. Aim 1. Provide enhanced mentoring to develop sustainable, independent, translational research projects for Junior Investigators. The three investigators will address three urgent challenges in pancreatic cancer: targeted drug delivery to desmoplastic tumors, synthesis and evaluation of new therapeutic agents, and determining epigenetic-genetic alternations in patient tissues for effective treatment. Each Junior Investigator will have two external mentors to encompass foundational and translational aspects. In addition, a clinician-scientist will serve as the Translational Science Liaison for the Center to bridge the foundational and translational elements. Aim 2. Augment biomedical research infrastructure of NDSU by expanding COBRE Core Facilities. We will expand the Animal Studies Core Facility to include tissue histology, imaging modalities, establish and maintain additional genetically engineered models, continue developing the PDX model systems, and establish a tissue biobank of human, PDX, and mouse pancreatic cancer tissues. In addition, the Biostatistics Core Facility will expand services to support projects using big data, bioinformatics, and machine-learning analysis. Aim 3. Integrate the Center into the national pancreatic cancer network. We will expand collaboration with eminent pancreatic cancer researchers in the US. We will build human capacity by hiring two new tenure track faculty members and recruiting four new Pilot Project investigators with expertise in translational aspects of pancreatic cancer. The Junior Investigators will compete for grants from NIH, NSF, DoD, and private foundations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	NORTH DAKOTA STATE UNIVERSITY	1301 12TH AVE N	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	8	10/11/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,860,485 )
2024	2024	NORTH DAKOTA STATE UNIVERSITY	1301 12TH AVE N	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	8	7/23/2024	NON-COMPETING CONTINUATION	$1,860,485
														Subtotal = $1,860,485

Issue Date FY: 2023 ( Subtotal = $1,894,145 )
2023	2023	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	005	7	7/6/2023	NON-COMPETING CONTINUATION	$1,894,145
2023	2022	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	004	6	6/22/2023	COMPETING CONTINUATION	$0
2023	2022	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	002	6	3/30/2023	COMPETING CONTINUATION	$0
2023	2022	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	001	6	1/11/2023	COMPETING CONTINUATION	$622,680
2023	2022	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	003	6	5/11/2023	COMPETING CONTINUATION	$0
2023	2020	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	000	5	1/11/2023	NON-COMPETING CONTINUATION	-$622,680
														Subtotal = $1,894,145

Issue Date FY: 2022 ( Subtotal = $2,088,884 )
2022	2022	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	002	6	7/15/2022	COMPETING CONTINUATION	$2,088,884
2022	2020	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	001	5	7/14/2022	NON-COMPETING CONTINUATION	$0
2022	2020	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	000	5	4/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,088,884

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	5	4/1/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,766,216 )
2020	2020	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	001	5	3/16/2020	NON-COMPETING CONTINUATION	$1,766,216
2020	2019	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	4	3/4/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,766,216

Issue Date FY: 2019 ( Subtotal = $1,822,547 )
2019	2019	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	001	4	4/1/2019	NON-COMPETING CONTINUATION	$1,822,547
2019	2018	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	3	11/8/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,822,547

Issue Date FY: 2018 ( Subtotal = $2,095,791 )
2018	2018	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	3	3/2/2018	NON-COMPETING CONTINUATION	$1,886,212
2018	2018	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	001	3	5/14/2018	NON-COMPETING CONTINUATION	$209,579
														Subtotal = $2,095,791

Issue Date FY: 2017 ( Subtotal = $1,875,968 )
2017	2017	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	2	2/27/2017	NON-COMPETING CONTINUATION	$1,688,371
2017	2017	NORTH DAKOTA STATE UNIVERSITY	1919 UNIVERSITY DR N, STE 102	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	001	2	7/10/2017	NON-COMPETING CONTINUATION	$187,597
														Subtotal = $1,875,968

Issue Date FY: 2016 ( Subtotal = $2,061,095 )
2016	2016	NORTH DAKOTA STATE UNIVERSITY	P.O. BOX 5405	FARGO	ND	58105	CASS	USA	Biomedical Research and Research Training	000	1	2/22/2016	NEW	$2,061,095
														Subtotal = $2,061,095

Grand Total All Awards = $15,465,131

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Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

Award Number: P20GM109024

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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