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Cellular Mechanisms of Inflammation, Hemostasis, and Thrombosis

Award Number: P01HL151433
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Cellular Mechanisms of Inflammation, Hemostasis, and Thrombosis - ABSTRACT Continued support is requested for an interdisciplinary effort to understand the key molecular and developmental events that regulate blood and vascular cells in inflammation, hemostasis and thrombosis with a focus on adhesive signaling. The four Projects will: 1) Test the hypothesis that an alternative IL-2 signaling pathway controls the immunological landscape and outcomes of vascular diseases associated with inflammation and thrombosis. 2) Test the hypothesis that an extended, but low affinity form of integrin αIIbβ3 mediates the clearance of platelets with dysregulated activation of Rap1 and can serve as a biomarker of thrombosis. 3) Test the hypothesis that chronic inflammation leads to changes in chromatin structure that result in a persistently activated endothelial cell predisposed to thrombosis and inflammation. 4) Test the hypothesis that recruitment of talin-1 and kindlin-3 in primary neutrophils are associated with marked differences in their adhesive behavior and kinetics of conformational changes in integrins. A scientific Core Unit A, led by a leader in multi-omic analysis of leukocytes, will provide the individual projects with expertise for experimental design required to establish the spatial molecular imaging of transcriptomes and proteomes of blood and vascular cells in situ and the technical capability to do so.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,363,208 )
2026	2026	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	001	6	9/3/2026	COMPETING CONTINUATION	$2,363,208
2026	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	000	5	3/5/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,363,208

Issue Date FY: 2024 ( Subtotal = $2,283,112 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	000	5	7/29/2024	NON-COMPETING CONTINUATION	$2,283,112
														Subtotal = $2,283,112

Issue Date FY: 2023 ( Subtotal = $2,333,519 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	000	4	8/8/2023	NON-COMPETING CONTINUATION	$2,333,519
														Subtotal = $2,333,519

Issue Date FY: 2022 ( Subtotal = $2,343,585 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	000	3	8/4/2022	NON-COMPETING CONTINUATION	$2,343,585
														Subtotal = $2,343,585

Issue Date FY: 2021 ( Subtotal = $2,340,324 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	001	2	8/10/2021	NON-COMPETING CONTINUATION	$2,340,324
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	002	2	8/20/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	000	1	5/6/2021	NEW	$0
														Subtotal = $2,340,324

Issue Date FY: 2020 ( Subtotal = $2,377,278 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	000	1	8/5/2020	NEW	$2,377,278
														Subtotal = $2,377,278

Grand Total All Awards = $14,041,026

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Cellular Mechanisms of Inflammation, Hemostasis, and Thrombosis

Award Number: P01HL151433

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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