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Phenix: Integrated algorithms for high quality models from crystallographic and cryo-EM data

Award Number: P01GM063210
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Overall Summary/Abstract The Phenix software has been developed as a result of the highly collaborative work of 4 groups located at Lawrence Berkeley Laboratory, Los Alamos National Laboratory, Cambridge University, and Duke University. Building on our prior work we will continue to collaborate in the development of new methods to improve structure solution, with a focus on low (near atomic) resolution (3-4.5Å). Researchers still encounter significant problems in solving and completing structures in this regime. Improvements in single wavelength anomalous (SAD) phasing, molecular replacement, model building, refinement and validation will make it possible for researchers to tackle more challenging experimental systems. This is particularly timely as new approaches to data collection, such as serial crystallography, are producing lower resolution structures of membrane proteins and large flexible complexes. Recent developments in the field of single particle cryo-electron microscopy (cryo-EM) have generated a rapid growth in the number of large macromolecular complexes solved ab initio. Therefore, a significant area of development for the Phenix team in the next 5 years will be cryo-EM, in particular near atomic resolution single particle image reconstruction. This is one of the most exciting developments in the field of structural biology in recent history. Our goal will be to collaborate to extend our current methods, and develop new ones, to address the problems of model fitting, model building, refinement and validation of atomic models derived from cryo-EM maps.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$989 )
2024	2021	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	20	6/6/2024	NON-COMPETING CONTINUATION	-$989
														Subtotal = -$989

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	20	8/9/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,896,774 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	20	5/10/2021	NON-COMPETING CONTINUATION	$1,896,774
														Subtotal = $1,896,774

Issue Date FY: 2020 ( Subtotal = $1,889,899 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	19	4/17/2020	NON-COMPETING CONTINUATION	$1,889,899
														Subtotal = $1,889,899

Issue Date FY: 2019 ( Subtotal = $1,872,254 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	18	5/21/2019	NON-COMPETING CONTINUATION	$1,872,254
														Subtotal = $1,872,254

Issue Date FY: 2018 ( Subtotal = $1,860,090 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	002	17	4/24/2018	NON-COMPETING CONTINUATION	$1,860,090
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	001	16	3/1/2018	COMPETING CONTINUATION	$263,028
2018	2015	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	15	3/1/2018	NON-COMPETING CONTINUATION	-$263,028
														Subtotal = $1,860,090

Issue Date FY: 2017 ( Subtotal = $1,842,139 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	001	16	4/19/2017	COMPETING CONTINUATION	$1,842,139
2017	2015	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1 CYCLOTRON RD	BERKELEY	CA	94720	ALAMEDA	USA	Biomedical Research and Research Training	000	15	4/14/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,842,139

Issue Date FY: 2015 ( Subtotal = $1,715,956 )
2015	2015	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	15	7/23/2015	NON-COMPETING CONTINUATION	$1,715,956
														Subtotal = $1,715,956

Issue Date FY: 2014 ( Subtotal = $1,716,302 )
2014	2014	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	14	8/20/2014	NON-COMPETING CONTINUATION	$1,716,302
														Subtotal = $1,716,302

Issue Date FY: 2013 ( Subtotal = $1,705,779 )
2013	2013	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	13	7/24/2013	NON-COMPETING CONTINUATION	$1,705,779
														Subtotal = $1,705,779

Issue Date FY: 2012 ( Subtotal = $1,711,669 )
2012	2012	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	12	7/27/2012	NON-COMPETING CONTINUATION	$1,711,669
														Subtotal = $1,711,669

Issue Date FY: 2011 ( Subtotal = $1,737,342 )
2011	2011	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	001	11	9/1/2011	COMPETING CONTINUATION	$1,737,342
2011	2010	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	10	8/30/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,737,342

Issue Date FY: 2010 ( Subtotal = $1,531,358 )
2010	2010	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	10	9/1/2010	NON-COMPETING CONTINUATION	$1,531,358
														Subtotal = $1,531,358

Issue Date FY: 2009 ( Subtotal = $1,964,806 )
2009	2009	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	9	8/5/2009	NON-COMPETING CONTINUATION	$1,598,683
2009	2009	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Trans-NIH Recovery Act Research Support	001	9	9/30/2009	SUPPLEMENT FOR EXPANSION	$366,123
														Subtotal = $1,964,806

Issue Date FY: 2008 ( Subtotal = $1,575,588 )
2008	2008	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	8	8/8/2008	NON-COMPETING CONTINUATION	$1,575,588
														Subtotal = $1,575,588

Issue Date FY: 2007 ( Subtotal = $1,568,939 )
2007	2007	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	7	7/27/2007	NON-COMPETING CONTINUATION	$1,568,939
														Subtotal = $1,568,939

Issue Date FY: 2006 ( Subtotal = $1,603,317 )
2006	2006	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	6	8/4/2006	COMPETING CONTINUATION	$1,603,317
														Subtotal = $1,603,317

Issue Date FY: 2005 ( Subtotal = $1,481,844 )
2005	2005	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	5	6/30/2005	NON-COMPETING CONTINUATION	$1,481,844
														Subtotal = $1,481,844

Issue Date FY: 2004 ( Subtotal = $1,444,821 )
2004	2004	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Biomedical Research and Research Training	000	4	6/30/2004	NON-COMPETING CONTINUATION	$1,444,821
														Subtotal = $1,444,821

Issue Date FY: 2003 ( Subtotal = $1,403,492 )
2003	2003	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Cell Biology and Biophysics Research	000	3	6/27/2003	NON-COMPETING CONTINUATION	$1,403,492
														Subtotal = $1,403,492

Issue Date FY: 2002 ( Subtotal = $1,450,780 )
2002	2002	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Cell Biology and Biophysics Research	000	2	6/28/2002	NON-COMPETING CONTINUATION	$1,450,780
														Subtotal = $1,450,780

Issue Date FY: 2001 ( Subtotal = $1,538,480 )
2001	2001	LAWRENCE BERKELEY LABORATORY	POST OFFICE BOX 528	BERKELEY	CA	94701	ALAMEDA	USA	Cell Biology and Biophysics Research	000	1	6/28/2001	NEW	$1,538,480
														Subtotal = $1,538,480

Grand Total All Awards = $33,510,640

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Phenix: Integrated algorithms for high quality models from crystallographic and cryo-EM data

Award Number: P01GM063210

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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