GHWIC Cycle 3 - Seattle Indian Health Board, with our public health division Urban Indian Health Institute (UIHI), requests $1,250,000 for Year 1 of a five-year project to implement Component 2 of the GHWIC program. We are applying as an Urban Indian Organization (UIO) to serve all 41 Indian Health Service UIOs. UIHI is a Public Health Authority and the only Tribal Epidemiology Center (TEC) focused on public health research, training, evaluation, and data for urban AI/AN health. Today, we serve 5.7 million urban AIAN people residing in 28 states and 164 counties across the U.S. UIHI is a national health leader in Indian Country and the current Component 2 GHWIC grantee. This project will focus on the 71% of AI/AN who live in urban environments. This proposal will build on UIHI’s existing work, infrastructure, and relationships to implement Component 2 strategies designed to improve the health and wellbeing of urban AI/AN people through reduced rates of death and disability from chronic diseases and reduced prevalence of commercial tobacco use, diabetes/prediabetes, high blood pressure, obesity, oral disease, and other chronic disease risk factors. Throughout the project period, we will deploy Indigenous knowledge-informed methods, framework, and evaluation approaches to support the delivery of Component 1 activities by UIOs and evidence-informed policy, systems, and environmental (PSE) changes. This project will achieve GHWIC goals through the following Component 2 Strategy 1 activities: (1) providing at least 36 subawards during the five-year project to UIOs and other members of the Urban Indian Health Network (UIHN), annually sub-granting at least 50% of our funding award; (2) providing training, technical assistance (TA), and resources to all UIOs to support the planning, development, implementation, and evaluation of activities across all C1 activities; (3) assisting UIOs to develop clinical sector linkages to community resources; and (4) working with UIOs to develop and implement tailored health communications and messaging. In addition, we will engage in a range of Component 2 Strategy 2 activities, including (1) assisting UIOs to establish PSE policies through a wise practice inquiry-based approach; (2) providing PSE-focused training, TA, and access to resources including the development of a PSE change tool kit for urban AI/AN organizations; and (3) assisting UIOs to heighten awareness regarding the power of PSE changes to promote health and wellness. Our proposed project activities will increase the number of UIOs across the country that are implementing activities across all GHWIC C1 strategies and that are effectively driving PSE change in their communities. Proposed outcomes are as follows: (1) 36 C1 projects will be implemented by UIOs and other UIHN members over the five-year funding period, with a minimum of six projects within each of the five C1 health focus priority areas; (2) 24 unique UIOs and other UIHN members will receive funding along with training and TA to implement C1 projects; and (3) 24 UIOs and other UIHN members will engage in PSE change activities. UIHI will conduct a process evaluation to inform continuous quality improvement and an outcome evaluation to assess our success in achieving the targeted outcomes, broadly disseminating our findings to inform future project activities and initiatives.