The purpose of this program is to reduce rates of death and disability from commercial tobacco use, diabetes, heart disease and stroke, among the American Indian population that reside in the Cherokee Nation reservation. The proposed program will implement Component 1 strategies and activities that will focus on reducing the prevalence of commercial tobacco use, reducing the incidence of type 2 diabetes and reducing the prevalence of high blood pressure and stroke. The proposed strategies and activities will aim to expand and enhance existing tribal public health efforts and support increased opportunities for American Indians residing in the Cherokee Nation to be engaged in healthy living practices. Specific interventions will target priority populations within the CN Reservation. While the CN Reservation encompasses 14 counties in Northeastern Oklahoma, program efforts will include 11 of those 14 counties for implementation of activities. These counties were selected to target based on the locations of Cherokee Nation clinics within these counties and the availability of public health educators within the tribally operated hospital and clinics. The following counties will be targeted for interventions: Adair, Cherokee, Craig, Delaware, Mayes, Muskogee, Nowata, Ottawa, Rogers, Washington and Sequoyah. Priority populations within these counties will be identified based on school districts with a high percentage of American Indian students and a high percentage of students eligible for free or reduced school meals which are reliable indicators of socio-economic status in this population.