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Pericoronary Adipose Tissue, Inflammation, and Subclinical Coronary Artery Disease in People with HIV in Uganda

Award Number: K43TW012846
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Pericoronary Adipose Tissue, Inflammation, and Subclinical Coronary Artery Disease in People with HIV in Uganda - PROJECT SUMMARY/ABSTRACT Background: People with HIV (PWH) are at increased risk of developing coronary artery disease (CAD) as compared to people without HIV (PWOH). The pathophysiology of CAD amongst PWH is believed to be due to an accelerated inflammatory process, resulting in formation of non-calcified, vulnerable plaques that are often not detected by standardized diagnostic methods. Pericoronary adipose tissue (PCAT) may serve as a feasible alternative imaging technique for early detection of coronary inflammation among PWH in Uganda, but has not been evaluated in the region. Candidate: The goal of the proposed K43 Emerging Global Leader (K43) Award is to support Dr. Prossy BIbangambah, a clinician scientist and faculty radiologist at Mbarara University of Science and Technology, to become an independent clinician-scientist with expertise in development and evaluation of innovative imaging techniques to elucidate the mechanisms of HIV-related cardiovascular disease (CVD) in sub-Saharan Africa. To achieve this, she will gain additional training in: 1) collection and analysis of cardiovascular image modalities for use in clinical research, 2) radiomics methods, including feature selection and machine learning to apply state-of-the-art technology to detect clinical abnormalities, and 3) statistical methods for diagnostic evaluation and risk prediction. This K43 project will help her achieve her long- term career goals through provision of didactic training in these key areas, mentorship from a team of world experts and practical research experience through the completion of her scientific aims. Research: Dr. Bibangambah will determine the relationship between PCAT, inflammation, and subclinical CAD in PWH by leveraging data and coronary computed tomography angiography (CCTA) images from two completed NIH- funded study cohorts through completion of the following aims: Aim 1: performing CCTA-based segmentation of PCAT and comparing the density between PWH and PWOH; Aim 2: using segmented images from Aim 1 to extract PCAT radiomics features and compare the difference in PCAT radiomics signatures between PWH and PWOH; and Aim 3: determining whether PCAT densities from Aim 1 or the radiomics signatures from Aim 2 improve the performance of cardiovascular risk prediction. Innovation: This study will be among the first to evaluate a novel tissue biomarker (PCAT) using CCTA-images and its relationship with inflammation and CAD in PWH in sub-Saharan Africa. Deliverables and future directions: With mentored training and skills gained from these scientific aims, Dr. Bibangambah will publish six manuscripts and be well-positioned to submit an NIH R01 proposal to evaluate the novel radiomics models/signature in predicting major adverse cardiovascular events (MACE) among people with and without HIV in Uganda.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $99,470 )
2025	2025	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	PLOT 8-18 KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	2	9/7/2025	NON-COMPETING CONTINUATION	$99,470
														Subtotal = $99,470

Issue Date FY: 2024 ( Subtotal = $99,384 )
2024	2024	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	PLOT 8-18 KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	1	8/23/2024	NEW	$99,384
2024	2024	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	PLOT 8-18 KABALE ROAD	MBARARA				UGA	International Research and Research Training	001	1	9/20/2024	NEW	$0
														Subtotal = $99,384

Grand Total All Awards = $198,854

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Pericoronary Adipose Tissue, Inflammation, and Subclinical Coronary Artery Disease in People with HIV in Uganda

Award Number: K43TW012846

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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