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Exposure to Mixtures of Emerging Contaminants in the Environment - Are Communities in Uganda at Health Risk?- A Case Study of Mbarara City.

Award Number: K43TW012594
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/27/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Exposure to Mixtures of Emerging Contaminants in the Environment - Are Communities in Uganda at Health Risk?- A Case Study of Mbarara City. - The rising environmental exposure to poorly characterized Emerging Industrial Pollutants (EIPs) threatens American public health. We hypothesize that EIPs exposure induces Non Communicable Diseases (NCDs), through metabolic perturbation. This study will test this hypothesis and provide evidence for targeted intervention strategies aligned to NIEHS goals and American health priorities of NCD prevention. The study is implemented at Mbarara University of Science and Technology (MUST) in Uganda, and mentored by the University of San Diego (USD) in the USA. Uganda offers unique high EIPs exposure scenarios, enabling identification of critical toxicity metabolic signatures that would be masked in low-exposure USA cohorts. Additionally, the expertise of the Ugandan team and established MUST-community relationships support the study. The findings will benefit American health by providing: (i) Early warning biomarkers, enabling USA clinicians transit from reactive treatment to proactive intervention for at risk communities. (ii) Critical toxicological data, to enable regulatory agencies (e.g. EPA) establish evidence-based Maximum Contaminant Levels (MCLs) for EIPs. (iii) Specific disrupted biological pathways, enabling USA researchers develop targeted and localized interventions. Candidate: Building on my BS, MSc, PhD training and research record (30 published articles), this K43 award will provide me critical mentorship and advanced training to become an independent investigator. My career goals focus on training in: (i) Qualitative and quantitative metabolomics; (ii) Advanced statistical analyses; (iii) Interpretation of metabolomics data; (iv) Leadership and professional skills and (v) Application of histopathology to chronic exposure studies. This award will enhance my skills in research methodology and administration, data management, responsible conduct of research (RCR), and grant writing. Mentors and Environment: This project leverages infrastructure at MUST, USD and Makerere University, guided by a multi-disciplinary mentorship team: Profs.Tusubira, Alele, Bolender and Ntale. My Research aims are to: (i) Identify and quantify EIPs in River Rwizi and catchment wastewater treatment plants (WWTPs). (ii) Evaluate the biological impact of chronic exposure to EIPs. My short-term goal is to identify specific biomarkers of EIP exposure, and my long term goal is to establish an independent career in Environmental toxicology. I will apply for an R01, towards the end of K43 funding period for research sustainability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $103,561 )
2026	2026	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	PLOT 8-18 KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	4	6/8/2026	NON-COMPETING CONTINUATION	$103,561
														Subtotal = $103,561

Issue Date FY: 2025 ( Subtotal = $93,940 )
2025	2025	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	PLOT 8-18 KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	3	5/19/2025	NON-COMPETING CONTINUATION	$93,940
														Subtotal = $93,940

Issue Date FY: 2024 ( Subtotal = $106,364 )
2024	2024	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	PLOT 8-18 KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	2	5/6/2024	NON-COMPETING CONTINUATION	$106,364
														Subtotal = $106,364

Issue Date FY: 2023 ( Subtotal = $108,103 )
2023	2023	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	001	1	8/31/2023	NEW	$0
2023	2023	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	1	7/26/2023	NEW	$108,103
														Subtotal = $108,103

Grand Total All Awards = $411,968

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Exposure to Mixtures of Emerging Contaminants in the Environment - Are Communities in Uganda at Health Risk?- A Case Study of Mbarara City.

Award Number: K43TW012594

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/27/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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