Monday, August 18, 2025 8/18/2025

Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy

Award Number: K24HL133373
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 07/31/2026

Group Awards By:

View Award Description

Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy - Abstract I have built a successful patient oriented research program focused on pharmacogenomics, pharmacoepidemiology, and chronic disease epidemiology with a focus on cardiovascular diseases. My research goal is to elucidate the role of clinical, environmental and genetic factors on variability in cardiovascular disease risk and response to medications and to use this information to tailor treatments, especially in patients with multiple comorbidities. The proposed award would enable me to continue mentoring while expanding my research program specifically incorporating implementation science tools to address key translational knowledge gaps. The new research proposed herein is builds on ongoing work to create unique and much needed patient oriented research (POR) training opportunities in cardiovascular pharmacotherapeutics and improvement in risk prediction by incorporating genomic information. My NIH grants along with the four new projects will form the basis for the mentee (MD, Pharm.D, and PhD) training. Mentorship aims expand the POR training opportunities for trainees. Mentees will lead the new projects, develop skills related to discovery and implementation, conduct analysis and publish original research. They will leverage this to propose new research as part of their NIH- K23 applications. PROJECT1 will elucidate the differential effect of sex and age on gene-hemorrhage association among anticoagulant users. PROJECT 2 will evaluate the influence of pharmacogenetic variants on Apixaban and Rivaroxaban pharmacokinetics and pharmacodynamics. PROJECT 3 will evaluate the performance of bleeding risk scores and the integration of genetics in risk prediction among patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). PROJECT 4 will evaluate the influence of heart failure on outcomes among patients with ACS undergoing PCI. In the supportive and collaborative environment of UAB, this award will ensure that I continue to grow my research program expand to include hybrid implementation-effectiveness designs and build capacity in POR by mentoring junior investigators to build their own careers. The breadth and depth of the multiple NIH- funded institutional training programs, UAB’s CTSA and her leadership in UAB’s Translational Pharmacogenomics and Precision Medicine Institute will provide the resources and the foundation to advance discovery and implementation efforts to enable translation of research discoveries into clinical care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $120,424 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	10	8/1/2025	NON-COMPETING CONTINUATION	$120,424
														Subtotal = $120,424

Issue Date FY: 2024 ( Subtotal = $120,424 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	9	8/5/2024	NON-COMPETING CONTINUATION	$120,424
														Subtotal = $120,424

Issue Date FY: 2023 ( Subtotal = $120,424 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	8	8/16/2023	NON-COMPETING CONTINUATION	$120,424
														Subtotal = $120,424

Issue Date FY: 2022 ( Subtotal = $120,424 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	002	7	8/26/2022	NON-COMPETING CONTINUATION	$120,424
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	001	6	11/24/2021	COMPETING CONTINUATION	$28,551
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	5	11/24/2021	NON-COMPETING CONTINUATION	-$28,551
														Subtotal = $120,424

Issue Date FY: 2021 ( Subtotal = $120,424 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	6	7/30/2021	COMPETING CONTINUATION	$120,424
														Subtotal = $120,424

Issue Date FY: 2020 ( Subtotal = $118,384 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	5	7/31/2020	NON-COMPETING CONTINUATION	$118,384
														Subtotal = $118,384

Issue Date FY: 2019 ( Subtotal = $118,384 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	4	7/31/2019	NON-COMPETING CONTINUATION	$118,384
														Subtotal = $118,384

Issue Date FY: 2018 ( Subtotal = $118,384 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	3	7/21/2018	NON-COMPETING CONTINUATION	$118,384
														Subtotal = $118,384

Issue Date FY: 2017 ( Subtotal = $118,384 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	2	7/31/2017	NON-COMPETING CONTINUATION	$118,384
														Subtotal = $118,384

Issue Date FY: 2016 ( Subtotal = $118,384 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	1	7/15/2016	NEW	$118,384
														Subtotal = $118,384

Grand Total All Awards = $1,194,040

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy

Award Number: K24HL133373

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 07/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer