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Understanding the Neurophysiology of Cognitive Control and its Development Using Single Unit Intracranial Recordings in Pediatric Patients with Epilepsy

Award Number: K23NS146764
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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Understanding the Neurophysiology of Cognitive Control and its Development Using Single Unit Intracranial Recordings in Pediatric Patients with Epilepsy - Project Summary/Abstract Adaptive, flexible control over one’s behavior is a hallmark of executive function and represents a key behavioral advantage to the survival of advanced vertebrates. Studies across the literature suggest that this “top-down” control develops into adulthood and is instantiated by prefrontal cortical regions, which “put the brakes” on phylogenetically older (subcortical) areas that modulate reflexive, autonomous, or ongoing behavior. While deficits in these pathways contribute to a variety of neuropsychiatric disorders, the precise mechanisms by which they influence behavior, and how they evolve during development, remain unknown. This mentored, patient- oriented proposal aims to interrogate these mechanisms using single unit and intracranial EEG (iEEG) recordings from pediatric patients undergoing intracranial electrode implantation for seizure onset zone mapping. Study design is based human and non-human primate work that utilizes an action modification (change signal) task to quantitatively elicit cognitive control. Single unit recordings from the dorsal anterior cingulate cortex (dACC) and presupplementary motor area (preSMA) will be combined with iEEG recordings from the inferior frontal gyrus (IFG) to identify the neurophysiological dynamics underlying behavioral performance within each patient. Data from patients at distinct developmental stages will then be analyzed to characterize how the neurophysiological correlates of cognitive control develop during brain maturation. The primary goal of this mentored project is to facilitate the candidate’s productive transition to scientific independence. The candidate’s neuroscientific and neurosurgical background will be augmented by theories and skillsets relevant to this project and to the field. These skills include human subject behavioral assay design; intracranial neurophysiology data acquisition; single unit and iEEG data analysis and interpretation; and organizational principles of laboratory management. The three project mentors, each internationally respected in the fields of systems and cognitive neuroscience, will provide high quality scientific and clinical guidance throughout the duration of the project. The candidate will also engage in dedicated didactic work relating to neurophysiological data acquisition and analysis and will attend multidisciplinary conferences at the national and international level to maintain contact with an evolving field. Ultimately, this mentored award will foster the candidate’s transition to scientific independence while advancing our understanding of circuit mechanisms governing cognitive control in pediatric patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $190,321 )
2026	2026	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/11/2026	NEW	$190,321
														Subtotal = $190,321

Grand Total All Awards = $190,321

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Understanding the Neurophysiology of Cognitive Control and its Development Using Single Unit Intracranial Recordings in Pediatric Patients with Epilepsy

Award Number: K23NS146764

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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