Monday, November 17, 2025 11/17/2025

Venous Thromboembolism: Enhancing Representation in Clinical Trials and Investigation of Sociodemographic and Clinical Factors Associated with Secondary Anticoagulation Use and Outcomes in Children

Award Number: K23HL175238
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/16/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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Venous Thromboembolism: Enhancing Representation in Clinical Trials and Investigation of Sociodemographic and Clinical Factors Associated with Secondary Anticoagulation Use and Outcomes in Children - PROJECT SUMMARY/ABSTRACT The rates of pediatric venous thromboembolism (VTE) have risen substantially over the last decade. Although 90% of pediatric VTE are provoked and carry a low risk for VTE recurrence (~1%), some children have a markedly higher risk for recurrence (16-29%) due to the presence of persistent prothrombotic risk factors (PPRF) after primary anticoagulant therapy. Better VTE prevention strategies are desperately needed. Unfortunately, the factors that contribute to VTE recurrence are not fully understood. Importantly, the impact of social determinants of health (SDOH) on pediatric VTE outcomes has been under studied. This proposal aims to address this critical knowledge gap by systematically analyzing VTE data derived from a multicenter prospective cohort study of pediatric VTE patients <21 years old with a first provoked VTE. The specific aims of this study are to characterize the types of PPRF after primary anticoagulant therapy (Aim1); identify risk factors (secondary anticoagulation use and SDOH) on rates of recurrent VTE one year post index VTE (Aim 2); and to identify facilitators and barriers (patient and provider) to secondary anticoagulation use and acceptability of future clinical trial participation (Aim 3). The applicant’s overarching career goal is to develop and apply field-leading expertise in the design, execution, and analysis of pragmatic clinical trials in children with VTE, with a focus on enhancing representation therein. She has designed a personalized career development plan with the overarching goal of acquiring skills to plan and conduct pediatric VTE randomized controlled trials, developing health disparities research skills to identify, and overcome barriers to care. The long-term goal for this research is to establish which children with PPRF have the highest risk of recurrent VTE and improve overall health outcomes by ushering in an era of riskstratified therapeutics in pediatric VTE management.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $186,153 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Blood Diseases and Resources Research	000	1	9/17/2025	NEW	$186,153
														Subtotal = $186,153

Grand Total All Awards = $186,153

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Venous Thromboembolism: Enhancing Representation in Clinical Trials and Investigation of Sociodemographic and Clinical Factors Associated with Secondary Anticoagulation Use and Outcomes in Children

Award Number: K23HL175238

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/16/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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