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Climate Variability and Respiratory Health in Asthma and COPD

Award Number: K23ES035863
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Climate Variability and Respiratory Health in Asthma and COPD - Dr. Nicholas Nassikas is a pulmonary and critical care physician whose long-term career goal is to determine how weather-related exposures affect the respiratory health of people with chronic lung disease. He has assembled a multidisciplinary and multi-institutional mentorship team with expertise in environmental epidemiology (Drs. Rice and Gold) and asthma (Dr. Israel), who have demonstrated a firm commitment to his long-term success as a clinical investigator. As part of the award, Dr. Nassikas will extend his skills in biostatistics, epidemiology, and statistical programming through formal coursework. Extreme weather across the United States has significant implications for human health. Dr. Nassikas’ study will evaluate associations of temperature and precipitation, and the extremes of each, on the respiratory health of those with chronic obstructive lung disease. His central hypothesis is that higher levels and variability of temperature and precipitation will be associated with more respiratory symptoms and exacerbations, lower lung function, and higher airway inflammation in adults with asthma and COPD. Dr. Nassikas will leverage three existing well characterized cohorts and recruit a prospective cohort of adults with asthma. He is well positioned to test his hypotheses in the following aims: (1) Determine if monthly extreme weather events (high/extreme heat, high wet-bulb globe temperature, heavy precipitation), temperature, and temperature variability are associated with respiratory symptoms and events in adults with chronic obstructive lung disease, (2) Determine if short-term differences in weather conditions are associated with lung function and airway inflammation in adults with chronic obstructive lung disease, and (3) Determine if temperature, temperature variability, and precipitation are associated with differences in symptoms and lung function in adults with asthma and, secondarily, to evaluate if associations are mediated by exposure to mold and aeroallergens. There is a very strong working history between the members of Dr. Nassikas’ mentorship team (Drs. Rice, Gold and Israel), who have published over 27 peer-reviewed manuscripts together. The well-coordinated supervision of Dr. Nassikas’ research activities and career development by his mentorship team follows an existing successful mentorship model. He will benefit from the outstanding and complementary environments at Beth Israel Deaconess Medical Center, Harvard School of Public Health, Brigham and Women’s Hospital. This proposal will provide valuable data and training in epidemiology and prospective study design and execution, which will lead directly to future R01 applications and support his development as an independent, grant-funded investigator.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $256,644 )
2026	2026	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Environmental Health	000	3	4/1/2026	NON-COMPETING CONTINUATION	$256,644
														Subtotal = $256,644

Issue Date FY: 2025 ( Subtotal = $256,202 )
2025	2025	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Environmental Health	001	2	4/9/2025	NON-COMPETING CONTINUATION	$0
2025	2025	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Environmental Health	000	2	3/17/2025	NON-COMPETING CONTINUATION	$256,202
														Subtotal = $256,202

Issue Date FY: 2024 ( Subtotal = $256,202 )
2024	2024	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Environmental Health	000	1	3/27/2024	NEW	$256,202
														Subtotal = $256,202

Grand Total All Awards = $769,048

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Climate Variability and Respiratory Health in Asthma and COPD

Award Number: K23ES035863

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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