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Brain Injury Knowledge Ontology (BIKO): Identifying Metadata Variance in Traumatic Brain Injury Therapy Studies

Award Number: K22NS125179
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/20/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Brain Injury Knowledge Ontology (BIKO): Identifying Metadata Variance in Traumatic Brain Injury Therapy Studies - Project Summary Traumatic brain injury is a significant cause of morbidity and mortality in the United States, yet there is no approved therapy for this injury. Although several therapies and procedures have been deemed successful for TBI treatment in preclinical research studies, many of these successes did not translate to human studies. One way to examine this challenge is to investigate the methodological variances in the associated literature. This proposal aims to use experimental methods and outcomes used in traumatic brain injury (TBI) therapy papers to create a metric to compare the methodological variance between multiple species by following three aims: 1. Training Phase 1: Establish the Brain Injury Knowledge Ontology (BIKO), a standardized ontology to define experimental design parameters and outcomes. 2. Training Phase 1: Create a knowledge base, BIKO base, of experimental design parameters (methods) and scientific claims (results) from the TBI treatment discovery literature. 3. Training Phase 2: Compare experimental differences hypothesized to lead to distinct outcomes between and across multiple species in TBI studies/literature using the BIKO. Upon completion, this project will provide a clearer understanding of past preclinical TBI therapy success and how it aligns to clinical outcomes to accelerate the discovery of successful therapies for TBI in human patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $176,796 )
2026	2026	HOWARD UNIVERSITY	2400 6TH ST NW	WASHINGTON	DC	20059	DISTRICT OF COLUMBIA	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	4/3/2026	EXTENSION WITH OR WITHOUT FUNDS	$176,796
														Subtotal = $176,796

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/16/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $107,662 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/16/2023	NON-COMPETING CONTINUATION	$107,662
														Subtotal = $107,662

Issue Date FY: 2022 ( Subtotal = $107,662 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/17/2022	NON-COMPETING CONTINUATION	$107,662
														Subtotal = $107,662

Issue Date FY: 2021 ( Subtotal = $107,902 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/18/2021	NEW	$107,902
														Subtotal = $107,902

Grand Total All Awards = $500,022

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Brain Injury Knowledge Ontology (BIKO): Identifying Metadata Variance in Traumatic Brain Injury Therapy Studies

Award Number: K22NS125179

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/20/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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