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Optimization and mechanisms of electrical neurostimulation in mouse models of epilepsy

Award Number: K08NS126730
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 12/01/2023
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Optimization and mechanisms of electrical neurostimulation in mouse models of epilepsy - PROJECT SUMMARY/ABSTRACT Drug-resistant epilepsy affects approximately 1 million people in the United States. Responsive neural stimulation (RNS) and deep brain stimulation (DBS) offer novel treatment options for refractory seizures. These neurostimulation therapies have significant advantages over surgical resection, though they are generally less effective. Treatment optimization has been challenging due to inter-patient variability, electrode placement, and the vast range of available stimulation parameters. This project aims to provide a more comprehensive description of the spatial and temporal dynamics that underlie neurostimulation and evaluate novel therapeutic effects that could prevent and modify the disease course in epilepsy. This proposal also outlines a five-year career development program focused on acquiring the skills necessary to perform an in-depth mechanistic analysis of neurostimulation in a rodent model of temporal lobe epilepsy. Washington University provides an excellent environment of collaborators and resources to develop skills necessary for investigating neurostimulation as a treatment modality for epilepsy. The outlined proposal builds on Dr. Foutz's prior research in deep brain stimulation and his clinical training in the field of epilepsy. Under the mentorship of Michael Wong, M.D., Ph.D. (basic scientist, clinical epileptologist), and Dominique Durand, Ph.D. (basic scientist, biomedical engineer), he will investigate the spatiotemporal dynamics underlying electrical neurostimulation and evaluate anti-epileptogenic effects. Dr. Foutz has a career goal to become a translational scientist focused on developing and optimizing device-based neuromodulatory treatments for patients with epilepsy. The career development plan outlines formal and informal training in animal models of epilepsy and neurostimulation. This work's potential impact is to optimize existing devices, guide the development of next- generation neurostimulation technology and discover novel therapeutic effects of neurostimulation in epilepsy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $232,981 )
2026	2026	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/18/2025	NON-COMPETING CONTINUATION	$232,981
														Subtotal = $232,981

Issue Date FY: 2025 ( Subtotal = $232,981 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/5/2024	NON-COMPETING CONTINUATION	$232,981
														Subtotal = $232,981

Issue Date FY: 2024 ( Subtotal = $232,981 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/28/2023	NEW	$232,981
														Subtotal = $232,981

Grand Total All Awards = $698,943

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Optimization and mechanisms of electrical neurostimulation in mouse models of epilepsy

Award Number: K08NS126730

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 12/01/2023

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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