Wednesday, July 30, 2025 7/30/2025

Role of Axonal Sprouting Mediated Network Reorganization in Stroke Recovery

Award Number: K08NS117888
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/15/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

Group Awards By:

View Award Description

Role of Axonal Sprouting Mediated Network Reorganization in Stroke Recovery - The goal of this mentored career development award is to facilitate the candidate’s transition to independence as a physician-scientist studying the molecular and neuronal mechanisms of stroke recovery. The candidate is an MD/PhD neurologist with a background in synaptic physiology and cortical network research. The award will help the candidate gain research experience in the mechanisms of network recovery after ischemic stroke and will facilitate his transition to an investigator with an independent laboratory. The award will also help position the candidate to achieve his long term goal of becoming a successful and productive physician-scientist, a leader in academic neurology, and a mediator of translational research which improves the lives of patients suffering from acute brain injury. The environment in which the proposed research will be conducted is outstanding. The candidate’s co-mentor, Dr. Jin-Moo Lee, is an internationally recognized scientist and neurologist with a proven track record of excellence in training junior faculty. The candidate’s career development plan also includes structured mentorship from multiple physician-scientists at all stages of seniority and exposure to a rich and supportive faculty, ensuring the candidate has role models along the full spectrum of the career trajectory. Didactic learning, presentation at scientific meetings, and rigorous training in the responsible conduct of research will ensure balanced development. The proposed research will examine the role of axonal sprouting in restoration of both local cortical circuits and secondary reconnection to global brain networks. Recovery after focal cortical stroke is associated with remapping of the function of the infarcted region to adjacent, non-infarcted cortex. Recovery is also associated with restoration of disrupted functionally connected networks. While both phenomena (local circuit remapping and restoration of functional connectivity) are strongly associated with stroke recovery, the underlying structural substrate is unknown. The goal of this project is to test the hypothesis that axonal sprouting mediates cortical remapping via reconnection of local circuits. A secondary hypothesis is that further axonal sprouting originating from the remapped cortex mediates restoration of whole-brain functional connectivity by reintegrating the disconnected circuit into global networks. This project further hypothesizes that the degree of recovery of these two processes (local remapping and restoration of functionally connected networks) correlates to the degree of behavioral stroke recovery. Clarifying the underlying mechanisms driving network repair after stroke will provide crucial insights into recovery after ischemic brain injury and will be the basis for future studies attempting to harness these mechanisms to improve outcomes for stroke survivors. This career development award is an ideal mechanism to provide the candidate with valuable research training to complement his clinical focus on caring for patients with acute brain injury and will help him develop a skill set for translating basic science discoveries into effective therapies for patients suffering from stroke.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $198,676 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/12/2025	NON-COMPETING CONTINUATION	$198,676
														Subtotal = $198,676

Issue Date FY: 2024 ( Subtotal = $198,676 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	3/14/2024	NON-COMPETING CONTINUATION	$198,676
														Subtotal = $198,676

Issue Date FY: 2023 ( Subtotal = $198,676 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/6/2023	NON-COMPETING CONTINUATION	$198,676
														Subtotal = $198,676

Issue Date FY: 2022 ( Subtotal = $198,676 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/7/2022	NEW	$198,676
														Subtotal = $198,676

Grand Total All Awards = $794,704

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Role of Axonal Sprouting Mediated Network Reorganization in Stroke Recovery

Award Number: K08NS117888

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/15/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer