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Defining the genetic contribution of glia in Parkinson's disease pathogenesis

Award Number: K08NS109344
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Defining the genetic contribution of glia in Parkinson's disease pathogenesis - The overarching goal of this project is to define the contribution of glia to Parkinson’s disease (PD) and thereby generate novel glial therapeutic targets. To do this, I will use an innovative approach that combines the power of Drosophila genetics with state of the art human cell culture systems. Specifically, I will identify novel glial modifiers of neuronal α-synuclein toxicity using a novel dual bipartite Drosophila α-synucleinopathy transgenic system, confirm the expression of these modifiers in human PD brain tissue, and then determine their mechanism using both Drosophila models and human cells by co-culturing human iPSC-derived astrocytes and neurons. In completing the project, I will gain essential training in these diverse, state of the art model systems, which will fill gaps in my current skillset. The career development plan has been carefully crafted to support my goal of becoming a leading independent investigator in PD research, simultaneously directing a research team and treating patients with PD. The plan includes an outstanding mentorship team composed of internationally known experts in neurodegeneration and Parkinson’s disease: Dr. Mel Feany, Dr. Dennis Selkoe, Dr. Clemens Scherzer, and Dr. Vikram Khurana. The senior members of my membership team have an outstanding record of training physician scientists who rise to prominence in the field of neurodegeneration. The institutional resources available through Brigham and Women’s Hospital and Harvard Medical School are world class and will support my career in an environment that can foster high impact contributions and collaborative endeavors. Upon successful completion of this project, I will be ideally positioned to be an independent investigator, answering fundamental questions about the contribution of glia to PD through the unique expertise I have gained in glial neurobiology in Drosophila and humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$262 )
2024	2022	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	2/20/2024	NON-COMPETING CONTINUATION	-$262
														Subtotal = -$262

Issue Date FY: 2023 ( Subtotal = -$65,090 )
2023	2022	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	1/12/2023	NON-COMPETING CONTINUATION	$0
2023	2021	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	6/29/2023	NON-COMPETING CONTINUATION	-$65,090
														Subtotal = -$65,090

Issue Date FY: 2022 ( Subtotal = $199,422 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	6	9/6/2022	NON-COMPETING CONTINUATION	$199,422
2022	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	5	8/29/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$23,001
2022	2021	BRIGHAM & WOMENS HOSPITAL INC	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/26/2022	NON-COMPETING CONTINUATION	-$23,001
														Subtotal = $199,422

Issue Date FY: 2021 ( Subtotal = $199,422 )
2021	2021	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	5/24/2021	NON-COMPETING CONTINUATION	$199,422
														Subtotal = $199,422

Issue Date FY: 2020 ( Subtotal = $199,422 )
2020	2020	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	6/9/2020	NON-COMPETING CONTINUATION	$199,422
														Subtotal = $199,422

Issue Date FY: 2019 ( Subtotal = $199,422 )
2019	2019	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	9/23/2019	NON-COMPETING CONTINUATION	$199,422
2019	2018	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/23/2019	NEW	$0
														Subtotal = $199,422

Issue Date FY: 2018 ( Subtotal = $199,800 )
2018	2018	BRIGHAM AND WOMEN'S HOSPITAL, INC., THE	75 FRANCIS ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/21/2018	NEW	$199,800
														Subtotal = $199,800

Grand Total All Awards = $932,136

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Defining the genetic contribution of glia in Parkinson's disease pathogenesis

Award Number: K08NS109344

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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