Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Proteostasis in Hematopoietic Stem Cell Development

Award Number: K08HL183828
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2031

Group Awards By:

View Award Description

Proteostasis in Hematopoietic Stem Cell Development - PROJECT SUMMARY/ABSTRACT Disruptions in hematopoietic stem cell (HSC) development occur in inherited bone marrow failure syndromes, but underlying mechanisms of HSC dysfunction in bone marrow failure are largely unknown and these disorders lack definitive cures aside from HSC transplant. Recent discoveries revealed that adult HSCs are particularly dependent on maintaining protein homeostasis (proteostasis), and modest disruptions in proteostasis preferentially impair HSC fitness and self-renewal. Emerging data suggests that many inherited bone marrow failure syndromes converge on impairments to the proteostasis network. This raises the possibility that proteostasis disruption in developing HSCs contributes to bone marrow failure, and interventions that promote proteostasis could serve as new therapies. In preliminary studies, I discovered that proteostasis is dynamically regulated in developing HSCs and that fetal HSCs activate stress response pathways to respond to disruptions in proteostasis. Based on these data, the goal of this proposal is to test the central hypothesis that disruptions in proteostasis during HSC development impair hematopoiesis and HSC function and can lead to bone marrow failure. Furthermore, I propose that proteostasis can be used as a biomarker of human HSC function, and interventions that buffer against proteostasis disruption can delay bone marrow failure in Diamond-Blackfan anemia syndrome (DBA), a disorder of erythroid failure. I am seeking K08 support to obtain protected time to complete training and laboratory research that will aid in my development into an independent physician-investigator. My long-term career goal is to develop targeted therapies for improving HSC function in pediatric bone marrow failure. I will complete the proposed project under the guidance of my primary mentor and advisory team, selected for their expertise in developmental hematopoiesis, bone marrow failure, and proteomics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $168,795 )
2026	2026	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Blood Diseases and Resources Research	000	1	8/26/2026	NEW	$168,795
														Subtotal = $168,795

Grand Total All Awards = $168,795

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Proteostasis in Hematopoietic Stem Cell Development

Award Number: K08HL183828

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer