Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Dissecting the Pleiotropic Roles of NFkB in Hematopoietic Aging

Award Number: K08HL181297
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2031

Group Awards By:

View Award Description

Dissecting the Pleiotropic Roles of NFkB in Hematopoietic Aging - PROJECT SUMMARY / ABSTRACT Hematopoietic aging is characterized by chronic inflammation, hematopoietic stem cell (HSC) dysfunction, and hematopoietic bias toward myeloid lineages, leading to less efficient immune responses and increasing incidence of hematologic neoplasia. Emerging evidence from our group and others shows that NFκB-mediated chronic inflammatory responses affect HSCs and their cellular niches in different ways. Elevated NFκB activity within HSCs leads to loss of replicative capacity, while in contrast, elevated NFκB within the bone marrow niche drives epigenomic reprogramming of HSCs and myeloid bias of their progeny. These observations lead to the central hypothesis of this proposal, that unique NFκB responses in HSCs and their niches together form a biologic buffering mechanism balancing inflammatory hematopoietic responses with HSC preservation to maintain lifelong blood production. Importantly, chronic and dysregulated inflammation is implicated in a wide range of blood disorders, yet the mechanisms governing HSC and niche cell responses remain unclear. Thus, the proposed studies are expected to open avenues of inquiry with broad relevance to hematopoietic aging, clonal hematopoiesis, myeloid neoplasia, aplastic anemia, iatrogenic myelosuppression, and more. This mentored career development award will support the advanced research training of Dr. Jennifer Chia, a hematopathologist at UCLA, to become an independent academic physician-scientist in the field of hematopoiesis. Dr. Chia received her MD and PhD degrees from the Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD program, and completed her Anatomic Pathology residency and Hematopathology fellowship at UCLA. She is now pursuing post-doctoral research training in the laboratory of Dr. Alexander Hoffmann, an internationally recognized expert in NFκB and the signaling systems that control immune cell function and fate decisions. The specific training objectives detailed in this proposal are to develop expertise in 1) inflammatory signaling and animal models of immune dysregulation; 2) HSC biology; 3) bioinformatics; and 4) the bone marrow niche. Training will be provided through mentorship by senior faculty members who are leaders in their fields, coursework, seminars, and conferences, all in the context of UCLA’s extensive resources and strong institutional commitment to the development of physician-scientists.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $153,464 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Blood Diseases and Resources Research	000	1	7/21/2026	NEW	$153,464
														Subtotal = $153,464

Grand Total All Awards = $153,464

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Dissecting the Pleiotropic Roles of NFkB in Hematopoietic Aging

Award Number: K08HL181297

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer