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Dissect stress response in skin epithelial wounding and hyperproliferative disorders

Award Number: K01AR072132
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2018
PERIOD OF PERFORMANCE END DATE: 03/31/2024

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Dissect stress response in skin epithelial wounding and hyperproliferative disorders - Project Summary During my PhD, I used skeletal myogenesis as my model to dissect signal transduction and gene regulation mechanisms. I have obtained technical literacy over a wide range of molecular biology and biochemical tools, accumulated critical experience on genetic mouse models, and developed critical and analytical thinking skills in experimental biology. I also came to appreciate the power of functional genomics, My so far 4.5-year's postdoc training focuses on interrogating molecular drivers in skin tumorigenesis fueled by stem cells, applying principles of functional genomics in mouse models, and validating findings in human clinic samples and xenografts. These training had expanded my research horizon, matured my experimental skills, and laid groundwork for me to ask important questions in human diseases. As I extend my training due to unexpected family difficulties, it would be essential for me to acquire additional scientific and academic skills that will enable me to gain full research autonomy and develop an innovative basic research program addressing fundamental questions in development and diseases. Over the past decades, we start to understand some of the molecular mechanisms involved in wound repair. We have also acquired substantial insights into oncogenic and tumor suppressive pathways in cancer. However, despite the long posited hypothesis that cancer is a wound that never heals, it is still unclear whether wounds and cancer functionally rely on the same stress components and if so, at which point they diverge. These are the primary focus of my current and future proposed research. I will establish and expand tools based on non- germline genetically engineered mosaic mouse models using in utero transduced CRISPR reagents. I will apply functional genomic approaches to prioritize and screen a focused list of stress relevant genes in driving wound repair and cancer. I will delineate molecular mechanisms that steer the long sought bifurcation point between the two stress conditions, and validate the physiological relevance of top my candidate stress genes in human samples. This knowledge will add to our understanding of the molecular mechanisms during cellular stress, and help to improve therapeutic treatments in skin wounds, hyperplasic diseases, and cancer. With the stimulating atmosphere provided by the Fuchs lab, the Rockefeller University, the Tri- Institution, and the broader NYC scientific community, I found myself positioned within an exceptional environment to pursue my ambition. If awarded, I will further obtain training in 1) technical skills – sequencing, advanced microscopy, CRISPR technology; and 2) personal development – writing, communication, mentoring, leadership, and management. My goal is, during the final years of K01, land in an independent tenure-track position with top-tier vibrating environment, especially those with an intensive emphasis on non-coding biology, where I will establish my own innovative, viable and sustainable research program in skin diseases and cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$3,337 )
2024	2022	THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	6	8/5/2024	NON-COMPETING CONTINUATION	-$3,337
														Subtotal = -$3,337

Issue Date FY: 2022 ( Subtotal = $134,655 )
2022	2022	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	6	3/16/2022	NON-COMPETING CONTINUATION	$134,655
														Subtotal = $134,655

Issue Date FY: 2021 ( Subtotal = $134,655 )
2021	2021	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	3/12/2021	NON-COMPETING CONTINUATION	$134,655
														Subtotal = $134,655

Issue Date FY: 2020 ( Subtotal = $134,655 )
2020	2020	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	3/16/2020	NON-COMPETING CONTINUATION	$134,655
														Subtotal = $134,655

Issue Date FY: 2019 ( Subtotal = $134,655 )
2019	2019	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	3	6/3/2019	NON-COMPETING CONTINUATION	$134,655
2019	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	3/15/2019	NEW	-$106,390
2019	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	1	3/18/2019	NEW	$78,125
2019	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	1	4/24/2019	NEW	$0
2019	2018	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	3/15/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$28,265
														Subtotal = $134,655

Issue Date FY: 2018 ( Subtotal = $134,655 )
2018	2018	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	3/5/2018	NEW	$134,655
														Subtotal = $134,655

Grand Total All Awards = $669,938

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Dissect stress response in skin epithelial wounding and hyperproliferative disorders

Award Number: K01AR072132

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2018

PERIOD OF PERFORMANCE END DATE: 03/31/2024

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