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CELL POLARITY AND THE CELL CYCLE IN C. ELEGANS.

Award Number: F32GM066546
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/15/2002
PERIOD OF PERFORMANCE END DATE: 08/14/2005

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CELL POLARITY AND THE CELL CYCLE IN C. ELEGANS. - DESCRIPTION (provided by applicant): This study asks what factors are involved in maintaining cell polarity during a series of unequal cell divisions in embryos of the roundworm C. elegans. Mutant embryos with prolonged cell cycles lose cell polarity and undergo abnormally equal cell divisions. I will reexamine cell division phenotypes in slow-cleaving mutants. Several mutant strains will be subjected to RNA-mediated interference (RNAi) to find out what additional genetic insults will modify their phenotype. Genes that affect kinetics of either cell cycle or polarity are expected to be recovered in this screen, and the RNiI method will allow genes of interest to be rapidly isolated for further analysis. At least two genes already known to affect both early cell cycle timing and later differentiation will also be cloned and functionally studied. This project aims to shed light on basic mechanisms of animal cells, in particular those modulating rates of DNA replication and cytoplasmic reorganization.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $24,464 )
2005	2005	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	001	3	12/9/2004	SUPPLEMENT FOR EXPANSION	$24,464
														Subtotal = $24,464

Issue Date FY: 2004 ( Subtotal = $24,464 )
2004	2004	UNIVERSITY OF OREGON	5219 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Biomedical Research and Research Training	000	3	7/15/2004	NON-COMPETING CONTINUATION	$24,464
														Subtotal = $24,464

Issue Date FY: 2003 ( Subtotal = $46,420 )
2003	2003	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Genetics and Developmental Biology Research and Research Training	000	2	7/21/2003	NON-COMPETING CONTINUATION	$46,420
														Subtotal = $46,420

Issue Date FY: 2002 ( Subtotal = $38,320 )
2002	2002	UNIVERSITY OF OREGON	5215 UNIVERSITY OF OREGON	EUGENE	OR	97403	LANE	USA	Genetics and Developmental Biology Research and Research Training	000	1	8/2/2002	NEW	$38,320
														Subtotal = $38,320

Grand Total All Awards = $133,668

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CELL POLARITY AND THE CELL CYCLE IN C. ELEGANS.

Award Number: F32GM066546

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/15/2002

PERIOD OF PERFORMANCE END DATE: 08/14/2005

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