Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Restoring the Sphingolipid Balance in Glioblastoma

Award Number: F31NS124130
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 05/01/2022
PERIOD OF PERFORMANCE END DATE: 12/09/2022

Group Awards By:

View Award Description

Restoring the Sphingolipid Balance in Glioblastoma - PROJECT SUMMARY/ABSTRACT The sphingolipid rheostat, which is the balance of ceramides and sphingosine-1-phosphate, is critical for regulating cell fate. Ceramides can be converted by ceramidases to sphingosine, which can then be converted by sphingosine kinase 1 to sphingosine-1-phosphate. Shifts toward sphingosine-1-phosphate production may allow cells to evade apoptosis and increase migration, while shifts toward ceramides may favor cell death. Dysregulated sphingolipid metabolism is associated with neurodegenerative disorders and cancer, although the sphingolipid rheostat is less well-studied in neural stem cells or brain tumors. The most common primary, malignant brain tumor is glioblastoma for which standard of care includes surgery, chemotherapy with temozolomide, and radiotherapy. This aggressive regimen fails to eradicate a subset of highly invasive, chemo- and radiotherapy resistant, neural stem cell-like, brain tumor initiating cells (BTICs) and glioblastoma quickly recurs. Radiotherapy can increase acid ceramidase (ASAH1) in BTICs, contributing to a shift in the sphingolipid balance towards sphingosine-1-phosphate. ASAH1 is highly expressed in glioblastoma and is associated with worse survival of glioma patients in The Cancer Genome Atlas data. ASAH1 inhibitors have been shown to increase pro-apoptotic ceramides and block the progression of some cancer types. We seek to determine whether an inhibitor of ASAH1, carmofur, is effective against BTICs derived from parental and temozolomide- resistant patient derived xenografts and to determine the impact of altered sphingolipid metabolism on glioblastoma migration and the brain tumor microenvironment. I anticipate that the studies proposed here will demonstrate that shifting the sphingolipid balance back toward ceramides is an effective therapeutic strategy in glioblastoma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$7,936 )
2024	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	10/31/2023	NEW	-$7,936
														Subtotal = -$7,936

Issue Date FY: 2023 ( Subtotal = -$3,813 )
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	3/31/2023	NEW	-$3,813
														Subtotal = -$3,813

Issue Date FY: 2022 ( Subtotal = $37,767 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	1	6/23/2022	NEW	-$1
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/13/2022	NEW	$37,051
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	5/4/2022	NEW	$717
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	4/19/2022	NEW	$0
														Subtotal = $37,767

Grand Total All Awards = $26,018

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Restoring the Sphingolipid Balance in Glioblastoma

Award Number: F31NS124130

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 05/01/2022

PERIOD OF PERFORMANCE END DATE: 12/09/2022

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer