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Determining the role of the long non-coding RNA HOTTIP in regulation of the HOXA gene cluster

Award Number: F31GM157953
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/01/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Determining the role of the long non-coding RNA HOTTIP in regulation of the HOXA gene cluster - Project Summary/Abstract Most transcription occurring in the human genome produces RNAs that do not encode proteins, and disruption of these non-coding RNAs (ncRNAs) is associated with multiple cancers. It is necessary to fully understand the role ncRNAs play in disease so that treatments and medicines can be developed. This project studies a particular ncRNA called HOTTIP which controls the expression of HOXA genes during the development of limbs. HOTTIP recruits the histone methyltransferase MLL1 to HOXA genes, however the mechanism of recruitment is unclear. By understanding how HOTTIP functions as a regulatory molecule, we can improve our knowledge of ncRNAs generally and identify ways to target ncRNAs therapeutically. This project involves creating a new technology through molecular engineering to determine the role of HOTTIP rapidly and confidently in human cells. It will be possible to uncover the exact way HOTTIP interacts with the MLL1 complex, and the degree the RNA molecule of HOTTIP itself is central to regulation of HOXA genes. This technology can then be used to study the thousands of other ncRNAs found in the human genome.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $49,538 )
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	2	12/26/2025	NON-COMPETING CONTINUATION	$49,538
														Subtotal = $49,538

Issue Date FY: 2025 ( Subtotal = $48,974 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	001	1	12/15/2024	NEW	$0
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Biomedical Research and Research Training	000	1	12/15/2024	NEW	$48,974
														Subtotal = $48,974

Grand Total All Awards = $98,512

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Determining the role of the long non-coding RNA HOTTIP in regulation of the HOXA gene cluster

Award Number: F31GM157953

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/01/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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