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Latent profiles of prenatal exposure to toxic metals and psychosocial risk and protective factors: testing associations with child developmental outcomes and moderations by caregiving experience

Award Number: F31ES034256
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 05/11/2024

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Latent profiles of prenatal exposure to toxic metals and psychosocial risk and protective factors: testing associations with child developmental outcomes and moderations by caregiving experience - PROJECT SUMMARY Exposures to toxic metals and psychological and social stressors during sensitive periods of fetal and infant development are associated with poorer child cognitive and socioemotional development. There is also evidence for moderating effects between toxic metals and psychological and social stressors, such that the effects of toxic metals on development may be conditional upon exposures to psychological and social stress and vice versa. Because physical, psychological, and social risk factors tend to cluster, the study of combined exposures may be more ecologically valid. Though prior studies have utilized two-way statistical interactions to examine these combined effects, these models still fall short in recognizing that individuals are concurrently exposed to multiple risk and protective factors across the physical and social environments. Previous studies have also failed to rigorously test the extent to which caregiving experience may mitigate or exacerbate the effects of prenatal exposure to toxic metals on child outcomes. Using longitudinal data from the Brain and Early Experiences Study and a finite mixture modeling approach, this study will: 1) categorize prenatal exposures to toxic metals, psychological and social risk factors, and protective factors into latent profiles of prenatal risk; 2) test associations between latent profiles of prenatal risk and indices of child cognitive and socioemotional development at 36 months old; and 3) examine indices of caregiving experience as moderators for the effects of latent profiles of prenatal risk on child cognitive and socioemotional development. Throughout these analyses, inferences between the latent profile approach and more traditional statistical approaches (i.e., two-way interactions) will be compared. This study will examine prenatal toxic metal and psychological and social risk holistically and has the potential to identify strategies to offset the effects of prenatal toxic metals and psychological and social risk on child development. The accompanying training plan will provide Ms. Wylie with the foundation to build her program of research which will combine developmental and public health sciences to study the joint influences of the physical and social environments on child development, and how positive social experience may be used to mitigate the effects of physical and chemical stressors. Specifically, Ms. Wylie will a) build her substantive expertise in early life environmental exposures relevant to child neurodevelopment and their mechanisms of action; b) expand her quantitative skillset towards the application of finite mixture models and moderation analyses; c) expand her expertise in the study of protective social environments in early life; and d) develop her interdisciplinary collaborations and career development skills. Ms. Wylie has assembled a stellar and cohesive mentorship team from the disciplines of developmental science, environmental science, and quantitative psychology. This mentorship team carries the expertise, experience, and dedication to Ms. Wylie’s professional development that will ensure the successful completion of her training goals and research plan.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$11,626 )
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Environmental Health	000	2	3/25/2025	NON-COMPETING CONTINUATION	-$11,626
														Subtotal = -$11,626

Issue Date FY: 2024 ( Subtotal = $14,646 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Environmental Health	001	2	7/22/2024	NON-COMPETING CONTINUATION	$1,780
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Environmental Health	000	2	2/21/2024	NON-COMPETING CONTINUATION	$41,661
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Environmental Health	002	2	8/5/2024	NON-COMPETING CONTINUATION	-$28,795
														Subtotal = $14,646

Issue Date FY: 2023 ( Subtotal = $41,661 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Environmental Health	001	1	2/13/2023	NEW	$942
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Environmental Health	002	1	2/13/2023	NEW	$0
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Environmental Health	000	1	1/11/2023	NEW	$40,719
														Subtotal = $41,661

Grand Total All Awards = $44,681

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Latent profiles of prenatal exposure to toxic metals and psychosocial risk and protective factors: testing associations with child developmental outcomes and moderations by caregiving experience

Award Number: F31ES034256

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 05/11/2024

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