Tuesday, September 16, 2025 9/16/2025

Circulatronics: A New Paradigm for Biomedical Implants

Award Number: DP2HL168072
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Circulatronics: A New Paradigm for Biomedical Implants - Modified Project Summary Section Bioelectronic implants provide a versatile platform for diagnosis, therapeutics as well as basic research but require invasive surgery. Here, we propose a paradigm shift: the ‘Circulatronics’ technology, wherein ultra-small bioelectronic devices target desired regions in the body for sensing and treatment, without the need for surgery. Its realization requires: i> nanoelectronic devices that are aggressively miniaturized (to fit inside vasculature) and extremely low power (to work deep inside body with low harvested energy); ii> heterogeneous integration of power-source and nanoelectronic circuits in a single device platform; iii> targeting the diseased regions for implantation without surgery. Accomplishing these requires innovations in diverse fields of applied physics, nanoelectronics and bioengineering and we are uniquely enabled due to our expertise in not only physics and solid-state nanoelectronic devices but also in bioelectronics, synthetic biology and neural engineering. We will build upon our work in developing ultra-scalable and record-low power nanoelectronics, which can lead to beyond-Silicon dimensional scalability to achieve i) and create sub-cellular sized and highly energy-efficient nanoelectronic devices. Moreover, we will leverage our research in building novel van der Waals heterostructures employing heterogeneous material systems enabled by atomically thin 2D materials to accomplish ii). For achieving iii), we will explore different surface functionalization techniques and leverage our expertise in synthetic biology. Circulatronics is a radical technology which can change the landscape of the field of biomedical implants and transform bioelectronic medicine. By alleviating surgery, it not only offers ultra-low invasiveness but can extend healthcare to patients not suited for surgery. These devices can modulate biological signals and can also integrate sensing functionalities. Since they can reach every nook and cranny of the body, they can obtain information from and treat intricate regions in body, which cannot be accessed by other technologies. Moreover, being extremely small, they can interact at a single cell or even subcellular level, to provide highly precise diagnosis and therapeutics as well as fundamental insights into biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $954,000 )
2025	2025	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Trans-NIH Research Support	000	2	8/19/2025	EXTENSION WITH OR WITHOUT FUNDS	$954,000
														Subtotal = $954,000

Issue Date FY: 2024 ( Subtotal = $397,500 )
2024	2024	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Blood Diseases and Resources Research	000	1	6/12/2024	SUPPLEMENT FOR EXPANSION	$397,500
														Subtotal = $397,500

Issue Date FY: 2022 ( Subtotal = $1,431,000 )
2022	2022	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASSACHUSETTS AVE	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Trans-NIH Research Support	000	1	8/29/2022	NEW	$1,431,000
														Subtotal = $1,431,000

Grand Total All Awards = $2,782,500

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Circulatronics: A New Paradigm for Biomedical Implants

Award Number: DP2HL168072

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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