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 | Issue Date FY: 2025 ( Subtotal = $63,730,298 ) (Continued on the next page) |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148343 | Mechanisms and regulation of replication, the cell cycle, gene expression, and horizontal gene transfer in prokaryotes, focusing on Bacillus subtilis. | 001 | 3 | NIH | 12/13/2024 | $673,334 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM158437 | Synthesis and Applications of Oligophosphate Constructs | 000 | 1 | NIH | 5/29/2025 | $444,262 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | UM1MH134812 | Center for Multi-Scale Multi-Omic Human and non-human primate Brain Atlas | 000 | 1 | NIH | 5/28/2025 | $11,731,574 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HL170537 | Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory Support | 002 | 2 | NIH | 2/28/2025 | $1 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HL170537 | Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory Support | 001 | 2 | NIH | 2/24/2025 | -$35,675 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HL170537 | Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory Support | 000 | 2 | NIH | 11/8/2024 | $48,974 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21ES036341 | Leveraging mutational analysis of cell-free DNA to identify carcinogenic exposure and enable early detection of cancer | 000 | 2 | NIH | 5/13/2025 | $198,750 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K00CA253767 | Targeting Endogenous Retrovirus Regulation for Augmenting Cancer Immunotherapy | 000 | 6 | NIH | 4/18/2025 | $107,050 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HD103847 | How do Cortical regions selective for visual scenes develop in human infants? | 000 | 5 | NIH | 6/5/2025 | $317,352 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM147960 | Mechanisms of replication origin licensing studied by real-time single-molecule fluorescence | 000 | 4 | NIH | 6/6/2025 | $384,301 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R25ES034600 | Short Courses for Teaching Gene-Environment Interactions for Health Professionals and Science Educators | 000 | 4 | NIH | 6/19/2025 | $215,105 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI155489 | Mechanisms of SFG Rickettsia-Host Interactions | 000 | 5 | NIH | 6/16/2025 | $738,563 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG074003 | Single-cell epigenomic and trancriptional dissection of sex-specific differences in Alzheimer’s Disease | 000 | 5 | NIH | 6/3/2025 | $1,068,252 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS123120 | Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems | 000 | 4 | NIH | 4/22/2025 | $364,659 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM144115 | Tissue morphogenesis: From signals to forces | 001 | 4 | NIH | 1/7/2025 | $489,141 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA271243 | Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer Models | 001 | 4 | NIH | 5/22/2025 | $51,143 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA271243 | Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer Models | 000 | 4 | NIH | 2/28/2025 | $460,286 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB036561 | A Portable, Liquid-Helium-Free 1-T/560-mm RT bore Point-of-Care MRI Magnet: Prototype Demonstration | 000 | 1 | NIH | 5/21/2025 | $514,357 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DA054584 | Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain | 001 | 4 | NIH | 4/10/2025 | $61,662 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DA054584 | Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain | 000 | 4 | NIH | 2/28/2025 | $554,968 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS141960 | Mechanisms of Network-Scale Neural Regeneration in a New Neuroscience Model | 000 | 1 | NIH | 5/1/2025 | $397,500 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC020484 | Neural Mechanisms that Underlie Flexible Sensory Control of Behavioral States in C. elegans | 000 | 3 | NIH | 2/19/2025 | $342,445 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD116425 | Developing a Biomimetic Lactating Mammary Lobe for Therapeutic Safety | 002 | 1 | NIH | 6/12/2025 | $1,284 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD116425 | Developing a Biomimetic Lactating Mammary Lobe for Therapeutic Safety | 001 | 1 | NIH | 3/19/2025 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD116425 | Developing a Biomimetic Lactating Mammary Lobe for Therapeutic Safety | 000 | 1 | NIH | 3/19/2025 | $76,756 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM144542 | Tools to determine and analyze the structures of molecular machines in motion | 000 | 4 | NIH | 2/19/2025 | $286,977 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB035127 | An integrated toolkit for real-time analysis of coupled nascent transcription | 000 | 2 | NIH | 3/17/2025 | $381,084 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB035127 | An integrated toolkit for real-time analysis of coupled nascent transcription | 001 | 2 | NIH | 6/25/2025 | $42,342 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS131457 | Brain-Wide Representations of Behavior During Aversive Internal States in C. Elegans | 000 | 3 | NIH | 2/14/2025 | $341,704 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R37CA273819 | Understanding the induction of T cell dysfunction in the context of lung cancer | 001 | 3 | NIH | 5/23/2025 | $46,215 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R37CA273819 | Understanding the induction of T cell dysfunction in the context of lung cancer | 000 | 3 | NIH | 2/17/2025 | $415,926 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH126351 | Spatiotemporal dynamics of locus coeruleus circuits during learned behavior | 000 | 5 | NIH | 2/14/2025 | $371,228 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH060379 | Functional and anatomical characterization of the striosomal system | 000 | 24 | NIH | 2/14/2025 | $329,588 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | UE5DA056914 | Program on Entrepreneurship and Innovation for Biomedical Product Development (EI4BPD) | 001 | 4 | NIH | 5/16/2025 | $330,802 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99CA287057 | Dietary Control of the Pro-Metastatic Niche in Colorectal Cancer | 000 | 2 | NIH | 12/13/2024 | $142,301 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB031992 | SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A | 000 | 4 | NIH | 1/16/2025 | $544,206 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U19AI167899 | Maternal Omics to Maximize Immunity | 001 | 4 | NIH | 5/19/2025 | $1,528,024 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U19AI167899 | Maternal Omics to Maximize Immunity | 001 | 4 | NIH | 5/19/2025 | $825,959 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U19AI167899 | Maternal Omics to Maximize Immunity | 002 | 4 | NIH | 6/17/2025 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U19AI167899 | Maternal Omics to Maximize Immunity | 002 | 4 | NIH | 6/17/2025 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH135141 | The role of top-down dendritic processing in credit assignment and cortical dynamics | 003 | 2 | NIH | 5/22/2025 | $103,927 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH135141 | The role of top-down dendritic processing in credit assignment and cortical dynamics | 001 | 2 | NIH | 4/17/2025 | $588,915 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG067151 | Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD | 001 | 5 | NIH | 6/18/2025 | $57,192 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG067151 | Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD | 000 | 5 | NIH | 3/13/2025 | $643,438 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC021970 | The brainstem vocal control circuits | 000 | 2 | NIH | 5/14/2025 | $558,565 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS135616 | Elucidating Neural Mechanisms Underlying Sickness Behaviors | 000 | 2 | NIH | 6/9/2025 | $474,348 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148220 | Protein Chemistry | 001 | 3 | NIH | 1/27/2025 | $452,433 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AI181878 | Systematic identification of novel anti-phage defense mechanisms in the E. coli pangenome | 000 | 2 | NIH | 11/19/2024 | $192,788 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL161069 | Personalized lesion modification optimizes atherosclerosis intervention | 000 | 4 | NIH | 1/3/2025 | $616,204 |
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