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 | Issue Date FY: 2025 ( Subtotal = $35,885,233 ) (Continued on the next page) |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HL178155 | Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes. | 001 | 1 | NIH | 12/20/2024 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HL178155 | Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes. | 000 | 1 | NIH | 12/20/2024 | $77,284 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS128717 | Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy | 000 | 2 | NIH | 12/20/2024 | $224,099 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS128717 | Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy | 001 | 2 | NIH | 1/3/2025 | -$224,099 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS128717 | Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy | 001 | 2 | NIH | 1/3/2025 | $224,099 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH131715 | Layer-specific manipulation to test feedforward/feedback cortical circuitry | 000 | 3 | NIH | 12/6/2024 | $246,666 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R33CA291166 | Advanced Development of Patient Ascites Therapeutic Response Biosensors | 000 | 1 | NIH | 2/20/2025 | $419,133 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HD110335 | Parsing the Interplay Between Biophysical and Biochemical Microenvironment Cues On Endometriosis Lesion Phenotypes Using Microphysiological Systems | 001 | 4 | NIH | 3/27/2025 | -$32,366 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HD110335 | Parsing the Interplay Between Biophysical and Biochemical Microenvironment Cues On Endometriosis Lesion Phenotypes Using Microphysiological Systems | 002 | 4 | NIH | 4/17/2025 | $32,366 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HD110335 | Parsing the Interplay Between Biophysical and Biochemical Microenvironment Cues On Endometriosis Lesion Phenotypes Using Microphysiological Systems | 000 | 4 | NIH | 3/25/2025 | $323,667 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM142634 | Mechanisms regulating ribosome assembly and function in stem cells and vertebrate development. | 000 | 5 | NIH | 4/21/2025 | $374,209 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM157940 | Machine Learning and Automated Flow Synthesis for the Development of Peptide Catalysts for the Stereo- and Site-Selective Formation of C–C Bonds | 000 | 1 | NIH | 11/15/2024 | $73,408 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM157940 | Machine Learning and Automated Flow Synthesis for the Development of Peptide Catalysts for the Stereo- and Site-Selective Formation of C–C Bonds | 001 | 1 | NIH | 11/15/2024 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HL170537 | Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory Support | 000 | 2 | NIH | 11/8/2024 | $48,974 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21ES036341 | Leveraging mutational analysis of cell-free DNA to identify carcinogenic exposure and enable early detection of cancer | 000 | 2 | NIH | 5/13/2025 | $198,750 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS123120 | Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems | 000 | 4 | NIH | 4/22/2025 | $364,659 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA271243 | Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer Models | 000 | 4 | NIH | 2/28/2025 | $460,286 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM144115 | Tissue morphogenesis: From signals to forces | 001 | 4 | NIH | 1/7/2025 | $489,141 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DA054584 | Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain | 000 | 4 | NIH | 2/28/2025 | $554,968 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DA054584 | Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain | 001 | 4 | NIH | 4/10/2025 | $61,662 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS141960 | Mechanisms of Network-Scale Neural Regeneration in a New Neuroscience Model | 000 | 1 | NIH | 5/1/2025 | $397,500 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35NS127327 | Molecular Mechanisms Underlying Cell Type-Specific Vulnerability in Huntington’s Disease | 000 | 4 | NIH | 4/28/2025 | $542,850 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH136275 | Neuron-Glial Interactions in Basal Ganglia Circuitry | 000 | 1 | NIH | 4/24/2025 | $725,422 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD116425 | Developing a Biomimetic Lactating Mammary Lobe for Therapeutic Safety | 001 | 1 | NIH | 3/19/2025 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD116425 | Developing a Biomimetic Lactating Mammary Lobe for Therapeutic Safety | 000 | 1 | NIH | 3/19/2025 | $76,756 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB035127 | An integrated toolkit for real-time analysis of coupled nascent transcription | 000 | 2 | NIH | 3/17/2025 | $381,084 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM141963 | Development of New Strategies for Chemical Synthesis and Study of Complex Natural Products | 001 | 5 | NIH | 4/14/2025 | $737,381 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM144542 | Tools to determine and analyze the structures of molecular machines in motion | 000 | 4 | NIH | 2/19/2025 | $286,977 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS117588 | Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation | 000 | 5 | NIH | 1/20/2025 | $348,975 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM157324 | Biogeography of Microbial and Plant-Derived Redox-Active Small Molecules and Combinatorial Effects on Microbial Growth | 000 | 1 | NIH | 4/11/2025 | $393,718 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG087374 | Lipid imaging expansion microscopy to study Alzheimer's disease | 000 | 2 | NIH | 3/6/2025 | $694,036 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC020484 | Neural Mechanisms that Underlie Flexible Sensory Control of Behavioral States in C. elegans | 000 | 3 | NIH | 2/19/2025 | $342,445 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA235375 | Delivery of cytokines for cancer immunotherapy using nanolayer-controlled trafficking of liposomal nanoparticles | 001 | 6 | NIH | 1/28/2025 | $353,924 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC022604 | Testing a mechanistic model for the storage and recall of an auditory memory underlying sensorimotor vocal learning | 000 | 1 | NIH | 5/1/2025 | $430,605 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R37CA273819 | Understanding the induction of T cell dysfunction in the context of lung cancer | 000 | 3 | NIH | 2/17/2025 | $415,926 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH126351 | Spatiotemporal dynamics of locus coeruleus circuits during learned behavior | 000 | 5 | NIH | 2/14/2025 | $371,228 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99CA287057 | Dietary Control of the Pro-Metastatic Niche in Colorectal Cancer | 000 | 2 | NIH | 12/13/2024 | $142,301 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB031992 | SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A | 000 | 4 | NIH | 1/16/2025 | $544,206 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148220 | Protein Chemistry | 001 | 3 | NIH | 1/27/2025 | $452,433 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG067151 | Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD | 000 | 5 | NIH | 3/13/2025 | $643,438 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH135141 | The role of top-down dendritic processing in credit assignment and cortical dynamics | 001 | 2 | NIH | 4/17/2025 | $588,915 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AI181878 | Systematic identification of novel anti-phage defense mechanisms in the E. coli pangenome | 000 | 2 | NIH | 11/19/2024 | $192,788 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL161069 | Personalized lesion modification optimizes atherosclerosis intervention | 000 | 4 | NIH | 1/3/2025 | $616,204 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA220468 | Organic nanoparticles for dual MRI-guided therapeutic selection and ovarian cancer drug delivery | 000 | 8 | NIH | 11/18/2024 | $536,334 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM153117 | Stereochemical Editing of Quaternary Stereocenters Enabled by Enantioselective Recombination of C–C Bonds | 000 | 2 | NIH | 12/20/2024 | $73,828 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG069232 | Manipulating Neural Oscillations with Non-Invasive Sensory Stimulation for Alzheimer's Disease Intervention | 000 | 4 | NIH | 1/9/2025 | $622,402 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG070135 | Sleep-dependent modulation of cerebrospinal fluid flow in aging | 000 | 6 | NIH | 3/27/2025 | $533,161 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K00CA264312 | Cellular engineering to improve the efficacy and specificity of targeted immunotherapy | 000 | 4 | NIH | 4/1/2025 | $94,921 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM085319 | Function of Sequence-specific RNA Binding Proteins | 000 | 16 | NIH | 4/21/2025 | $326,228 |
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