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 | Issue Date FY: 2023 ( Subtotal = $117,126,101 ) (Continued on the next page) |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R37CA273819 | Understanding the induction of T cell dysfunction in the context of lung cancer | 000 | 1 | NIH | 3/14/2023 | $476,553 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HG013052 | Developing an ultra-high throughput droplet microfluidic workflow for genetic circuit characterization | 000 | 1 | NIH | 3/29/2023 | $47,694 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG074932 | Discovery and manipulation of transcription factors to restore long term stem cell repopulation in aged bone-marrow | 000 | 2 | NIH | 4/19/2023 | $611,230 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21MH130624 | Investigation of the Synaptic Molecular Network using Multiplexed Imaging | 000 | 2 | NIH | 6/14/2023 | $189,310 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U18TR004149 | Informatics and Machine Learning Modules for Research Planning, Scheduling, Simulation, and Optimization in the ASPIRE Autonomous Laboratory | 001 | 2 | NIH | 5/5/2023 | $575,034 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EY034080 | Novel ultrahigh speed swept source OCT angiography methods in diabetic retinopathy | 000 | 1 | NIH | 7/6/2023 | $500,682 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS131457 | Brain-wide representations of behavior during aversive internal states in C. elegans | 000 | 1 | NIH | 2/17/2023 | $381,016 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HG013052 | Developing an ultra-high throughput droplet microfluidic workflow for genetic circuit characterization | 001 | 1 | NIH | 3/29/2023 | $0 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM147937 | Selective C(sp3)?H Functionalization Enabled by Metal-Organic Framework Catalysis | 001 | 1 | NIH | 3/27/2023 | $0 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35NS127327 | Molecular Mechanisms Underlying Cell Type-Specific Vulnerability in Huntington?s Disease | 000 | 2 | NIH | 4/26/2023 | $542,850 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS123120 | Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems | 000 | 2 | NIH | 4/26/2023 | $393,724 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AI171663 | Biochemical Strategy to Avert Microbial Drug Resistance | 000 | 2 | NIH | 6/2/2023 | $155,100 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | UM1NS132173 | BRAIN CONNECTS: Comprehensive regional projection map of marmoset with single axon and cell type resolution | 000 | 1 | NIH | 9/6/2023 | $3,615,967 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99AG076987 | Understanding the role of the stromal cell niche in intestinal stem cell aging | 000 | 1 | NIH | 7/18/2023 | $136,674 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM147794 | A Benchtop Cryogen-Free 23.5-T/25-mm-RT-Bore Magnet for 1-GHz microcoil NMR Spectroscopy | 000 | 2 | NIH | 8/9/2023 | $392,365 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM147937 | Selective C(sp3)?H Functionalization Enabled by Metal-Organic Framework Catalysis | 000 | 1 | NIH | 3/27/2023 | $68,684 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG058504 | Solid State NMR Studies of Amyloid Proteins | 000 | 3 | NIH | 6/15/2023 | $708,527 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31GM148069 | Enzymatic Mechanism of Polysaccharide Length Control by GlfT2 | 000 | 2 | NIH | 8/17/2023 | $47,694 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F99CA274651 | Engineering Next-Generation Nanoparticles One Layer at a Time | 001 | 2 | NIH | 8/1/2023 | $47,694 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AI179432 | Mechanism of nuclear pore passage of the HIV-1 capsid | 000 | 1 | NIH | 5/22/2023 | $237,123 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R24OD035444 | Expanding access to Genomics Methods through Modern Focused Ultrasonication | 000 | 1 | NIH | 7/11/2023 | $128,817 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EY034419 | Characterizing excitatory synapse in vivo structural dynamics | 000 | 2 | NIH | 7/31/2023 | $475,001 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 001 | 1 | NIH | 7/24/2023 | -$352,082 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | UG3CA275687 | Single-cell label-free identification of senescence by Raman microscopy and spatial genomics | 000 | 2 | NIH | 8/25/2023 | $550,000 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32NS128067 | Single Cell Dissection of Cerebrovascular Dysfunction in Parkinson's Disease and Amyotrophic Lateral Sclerosis | 000 | 2 | NIH | 7/24/2023 | $69,500 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG082871 | Disparities in the Quality of Nursing Home Care | 000 | 1 | NIH | 7/26/2023 | $626,840 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | RF1MH132747 | Psych-DS: A FAIR data standard for behavioral datasets | 000 | 1 | NIH | 7/28/2023 | $1,093,825 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99GM149815 | Dissecting enhancer-promoter looping and gene induction dynamics in differentiation | 000 | 1 | NIH | 3/14/2023 | $125,000 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 001 | 1 | NIH | 7/24/2023 | $352,082 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U01AG077227 | Mapping the vulnerable locus coeruleus pathways in aging and AD | 000 | 2 | NIH | 8/24/2023 | $1,955,844 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00GM140265 | Understanding mechanisms of transcriptional regulation by chromatin adaptor proteins | 000 | 3 | NIH | 6/1/2023 | $248,999 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31CA275339 | Interrogation of retroelement-derived proteins for functional gene transfer | 000 | 2 | NIH | 8/30/2023 | $43,631 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F99HG013039 | Leveraging natural and engineered genetic barcodes from single cell RNA sequencing to investigate cellular evolution, clonal expansion, and associations between cellular genotypes and phenotypes | 000 | 1 | NIH | 5/5/2023 | $20,399 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31MH133329 | A multi-modal, brain-wide atlas of astrocyte diversity across developmental stages and model species | 000 | 1 | NIH | 3/13/2023 | $47,694 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 000 | 1 | NIH | 2/14/2023 | $469,443 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31GM146448 | Biochemical and Biophysical Studies of Human Ribonucleotide Reductase | 000 | 2 | NIH | 5/4/2023 | $47,694 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32AI172121 | Investigating genes of unknown function required for Rickettsia parkeri infection | 000 | 2 | NIH | 7/21/2023 | $69,500 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F99HG013039 | Leveraging natural and engineered genetic barcodes from single cell RNA sequencing to investigate cellular evolution, clonal expansion, and associations between cellular genotypes and phenotypes | 000 | 1 | NIH | 5/5/2023 | $28,795 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM150211 | Peptide-Conjugated Palladium Oxidative Addition Complexes for Site-Selective Arylation Chemistry | 001 | 1 | NIH | 4/3/2023 | $0 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AI167289 | Identifying mucin O-glycans in the regulation of Staphylococcus aureus pathogenesis | 000 | 2 | NIH | 4/10/2023 | $229,150 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31GM148042 | Anti-CRISPR-mediated Acylation and Bioreversible Esterification for Precision Genome Editing | 000 | 2 | NIH | 6/26/2023 | $47,694 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | UE5DA056914 | Program on Entrepreneurship and Innovation for Biomedical Product Development (EI4BPD) | 000 | 2 | NIH | 5/31/2023 | $339,535 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | DP1NS137188 | Unraveling the Neural Bases of Body Schema | 000 | 1 | NIH | 9/7/2023 | $1,113,000 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM149227 | Computational and Experimental Investigation and Design of Protein Interaction Specificity | 000 | 1 | NIH | 5/31/2023 | $548,343 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K01AG083734 | Engineering Immuno-Glial-Neurovascular 3D-Brain-Chips with a Perfusable BBB for Accelerating Alzheimer?s Disease Drug Discovery and Translation | 000 | 1 | NIH | 8/10/2023 | $163,901 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS119749 | A New Animal Model to Examine Nervous System Function Development and Regeneration | 001 | 3 | NIH | 3/14/2023 | -$248,999 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM150211 | Peptide-Conjugated Palladium Oxidative Addition Complexes for Site-Selective Arylation Chemistry | 000 | 1 | NIH | 4/3/2023 | $69,080 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99EB032427 | Development of bio-integrated devices to enhance transplant survival for subcutaneous encapsulated cell therapies | 000 | 2 | NIH | 5/8/2023 | $87,682 |
| | 2023 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99GM145910 | Investigation and application of hydrocarbon-degrading enzymes using cryo-electron microscopy and directed evolution | 000 | 2 | NIH | 6/30/2023 | $12,453 |
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