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 | Issue Date FY: 2025 ( Subtotal = $972,882 ) |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA220468 | Bottlebrush polymer prodrugs for targeted delivery of combination therapies and in vivo imaging of pharmacological response | 000 | 8 | NIH | 11/18/2024 | $536,334 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM140108 | Mechanobiology of Vimentin Intermediate Filaments in 3D Collective Cell Migration | 000 | 5 | NIH | 11/19/2024 | $374,213 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AI181878 | Systematic identification of novel anti-phage defense mechanisms in the E. coli pangenome | 000 | 2 | NIH | 11/19/2024 | $192,788 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM157940 | Machine Learning and Automated Flow Synthesis for the Development of Peptide Catalysts for the Stereo- and Site-Selective Formation of C–C Bonds | 000 | 1 | NIH | 11/15/2024 | $73,408 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HL170537 | Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory Support | 000 | 2 | NIH | 11/8/2024 | $48,974 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM154393 | Dynamics and mechanisms of long-range enhancer activity | 000 | 1 | NIH | 11/8/2024 | $73,828 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC000238 | Experimental Theoretical Studies of Cochlear Mechanisms | 000 | 39 | NIH | 11/14/2024 | $331,691 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM141861 | Manifold representations and active learning for 21 st century biology | 000 | 4 | NIH | 11/12/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM124732 | Evolution and Regulation of Bacterial Proteome Composition | 000 | 7 | NIH | 11/11/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM126982 | Metalloenzyme structure, function and assembly | 000 | 7 | NIH | 11/6/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R33AI161805 | Combinatorial and computational design of bnAb mRNA vaccines for HIV | 000 | 4 | NIH | 10/30/2024 | $593,263 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148220 | Protein Chemistry | 000 | 2 | NIH | 11/11/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99GM152834 | Regulation of oxidative stress signaling by tyrosine phosphorylation of antioxidant enzymes | 001 | 2 | NIH | 11/19/2024 | -$74,931 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM152027 | Revealing Nature's Blueprints for Single-Site Catalysis of C-H Activation with First-principles Modeling and Machine Learning | 000 | 1 | NIH | 11/11/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R33AI161297 | Immune engineering of optimized sequential immunization strategies for HIV vaccines | 000 | 4 | NIH | 10/30/2024 | $35,196 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99GM152834 | Regulation of oxidative stress signaling by tyrosine phosphorylation of antioxidant enzymes | 000 | 2 | NIH | 10/31/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM149227 | Computational and Experimental Investigation and Design of Protein Interaction Specificity | 000 | 2 | NIH | 11/5/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM136354 | Leveraging Next-Generation Directed Evolution Platforms and Chemical Control of Proteostasis to Deliver Robust Biotechnologies and Illuminate Roles of Chaperone Networks in Protein Evolution | 000 | 5 | NIH | 11/7/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148287 | Revealing transmembrane conformational signaling through single-molecule FRET | 000 | 2 | NIH | 11/5/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM141963 | Development of New Strategies for Chemical Synthesis and Study of Complex Natural Products | 000 | 4 | NIH | 11/6/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM131627 | Structure and function of the monotopic phosphoglycosyl transferase superfamily: Initiators of biosynthesis of complex bacterial glycoconjugates | 000 | 6 | NIH | 11/19/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM141517 | Structure and function of ClpXP | 000 | 4 | NIH | 11/19/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM133580 | Probing and Perturbing Transcriptional Condensates with Multiscale Modeling and Deep Learning | 000 | 6 | NIH | 11/7/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM144115 | Tissue morphogenesis: From signals to forces | 000 | 3 | NIH | 11/6/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL172065 | Multi-electroplasmonic nanoantenna arrays for wireless transmembrane-level recording of cardiomyocyte action potentials with sub-micrometer resolution | 000 | 1 | NIH | 11/9/2024 | $0 |
| | 2025 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148343 | Mechanisms and regulation of replication, the cell cycle, gene expression, and horizontal gene transfer in prokaryotes, focusing on Bacillus subtilis. | 000 | 2 | NIH | 11/11/2024 | $0 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R61AI161805 | Combinatorial and computational design of bnAb mRNA vaccines for HIV | 000 | 3 | NIH | 10/30/2024 | -$593,263 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R61AI161297 | Immune engineering of optimized sequential immunization strategies for HIV vaccines | 000 | 3 | NIH | 10/30/2024 | -$35,196 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS113079 | Dendritic Computation and Representation of Head Direction in Retrosplenial Cortex | 000 | 5 | NIH | 11/1/2024 | $0 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC017970 | Computational Cognitive Neuroscience of Human Auditory Cortex | 000 | 5 | NIH | 10/28/2024 | $0 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH122025 | CRCNS: US-French Research Proposal: Principles of Inference through Neural Dynamics | 000 | 5 | NIH | 10/28/2024 | -$50 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH104536 | Imaging Synaptic Transmission of Individual Active Zones | 000 | 10 | NIH | 11/7/2024 | $0 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA235375 | Delivery of cytokines for cancer immunotherapy using nanolayer-controlled trafficking of liposomal nanoparticles | 000 | 5 | NIH | 10/29/2024 | $0 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH122270 | Characterization of amygdalar circuits mediating suppression of innate social behaviors | 000 | 5 | NIH | 10/22/2024 | $0 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | UH3NS115064 | Construction of an Integrated Immune - Vascular Brain - Chip as a Platform for the Study, Drug Screening, and Treatments of Alzheimer's Disease | 000 | 4 | NIH | 10/16/2024 | $0 |
| | 2025 | 2023 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM148745 | Developing programmable RNA writing tools with the novel RNA-guided RNA-targeting CRISPR effector Cas7-11 | 000 | 1 | NIH | 11/14/2024 | -$556,500 |
| | 2025 | 2022 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | DP5OD026369 | Dissecting and engineering reversible cell cycle states | 000 | 5 | NIH | 11/21/2024 | -$298 |
| | 2025 | 2021 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U19AI131135 | 3D Models of Engineered Human iPS Cells to Investigate Neurotropic Virus Infections | 000 | 5 | NIH | 10/25/2024 | -$26,575 |
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| Issue Date FY: 2024 ( Subtotal = $112,357,050 ) (Continued on the next page) |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL161069 | Personalized lesion modification optimizes atherosclerosis intervention | 000 | 3 | NIH | 12/20/2023 | $620,595 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM154448 | Investigating mechanisms of coordinating actinstructure across multiple levels oforder | 001 | 1 | NIH | 5/24/2024 | $0 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM126376 | Metallobiochemistry of innate immunity and bacterial physiology | 000 | 8 | NIH | 8/16/2024 | $320,529 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM154448 | Investigating mechanisms of coordinating actinstructure across multiple levels oforder | 000 | 1 | NIH | 5/24/2024 | $77,284 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA271243 | Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer Models | 001 | 3 | NIH | 4/18/2024 | $25,511 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R24MH117295 | DANDI: Distributed Archives for Neurophysiology Data Integration | 000 | 6 | NIH | 4/26/2024 | $1,898,066 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI168166 | Defining the Interplay Between Viral Adaptation and Host Proteostasis | 000 | 3 | NIH | 6/28/2024 | $584,656 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R24MH117295 | DANDI: Distributed Archives for Neurophysiology Data Integration | 001 | 6 | NIH | 9/20/2024 | -$100,000 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R24MH117295 | DANDI: Distributed Archives for Neurophysiology Data Integration | 001 | 6 | NIH | 9/20/2024 | $100,000 |
| | 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99GM152834 | Regulation of oxidative stress signaling by tyrosine phosphorylation of antioxidant enzymes | 000 | 2 | NIH | 8/23/2024 | $125,000 |
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