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 | Issue Date FY: 2025 ( Subtotal = $21,859,603 ) (Continued on the next page) |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DA062195 | Analyzing brain-wide bases of neuroplastic change using new imaging tools | 000 | 1 | NIH | 12/26/2024 | $613,107 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM153117 | Stereochemical Editing of Quaternary Stereocenters Enabled by Enantioselective Recombination of C–C Bonds | 000 | 2 | NIH | 12/20/2024 | $73,828 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148220 | Protein Chemistry | 001 | 3 | NIH | 1/27/2025 | $452,433 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS117588 | Molecular and Cellular Mechanisms Mediating Structural and Functional Active Zone Maturation | 000 | 5 | NIH | 1/20/2025 | $348,975 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21HL177773 | Emulated Target Trials of Steroids in Patients with Acute Respiratory Distress Syndrome | 000 | 1 | NIH | 1/13/2025 | $153,099 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM154393 | Dynamics and mechanisms of long-range enhancer activity | 001 | 1 | NIH | 11/8/2024 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM156872 | Chemical Approaches to Understanding the Mechanisms of Iron-Sulfur Enzymes | 000 | 1 | NIH | 1/21/2025 | $647,301 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA235375 | Delivery of cytokines for cancer immunotherapy using nanolayer-controlled trafficking of liposomal nanoparticles | 001 | 6 | NIH | 1/28/2025 | $353,924 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA249151 | Increasing nerve-sparing radical prostatectomy rates using intraoperative nonlinear microscopy | 000 | 5 | NIH | 1/21/2025 | $393,426 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31NS141336 | In Vivo Measurement of Human Brain Tissue, Blood, and CSF Dynamics Supporting Glymphatic Function | 000 | 1 | NIH | 1/20/2025 | $48,974 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM157624 | Cationic Carbone-Boracycles as Far-Red and Near-Infrared Photoactive Agents | 000 | 1 | NIH | 12/17/2024 | $351,010 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA220468 | Organic nanoparticles for dual MRI-guided therapeutic selection and ovarian cancer drug delivery | 000 | 8 | NIH | 11/18/2024 | $536,334 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM157940 | Machine Learning and Automated Flow Synthesis for the Development of Peptide Catalysts for the Stereo- and Site-Selective Formation of C–C Bonds | 000 | 1 | NIH | 11/15/2024 | $73,408 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AI181878 | Systematic identification of novel anti-phage defense mechanisms in the E. coli pangenome | 000 | 2 | NIH | 11/19/2024 | $192,788 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM140108 | Mechanobiology of Vimentin Intermediate Filaments in 3D Collective Cell Migration | 000 | 5 | NIH | 11/19/2024 | $374,213 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS128717 | Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy | 001 | 2 | NIH | 1/3/2025 | -$224,099 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS128717 | Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy | 001 | 2 | NIH | 1/3/2025 | $224,099 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM157940 | Machine Learning and Automated Flow Synthesis for the Development of Peptide Catalysts for the Stereo- and Site-Selective Formation of C–C Bonds | 001 | 1 | NIH | 11/15/2024 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL161069 | Personalized lesion modification optimizes atherosclerosis intervention | 000 | 4 | NIH | 1/3/2025 | $616,204 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM154393 | Dynamics and mechanisms of long-range enhancer activity | 000 | 1 | NIH | 11/8/2024 | $73,828 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31HL170537 | Optimization of Right and Left Ventricular Coupling During Mechanical Circulatory Support | 000 | 2 | NIH | 11/8/2024 | $48,974 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R33CA291166 | Advanced Development of Patient Ascites Therapeutic Response Biosensors | 000 | 1 | NIH | 2/20/2025 | $419,133 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM141275 | Selective Catalytic Strategies for Carbohydrate Synthesis | 000 | 4 | NIH | 3/5/2025 | $263,441 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG082871 | Disparities in the Quality of Nursing Home Care | 000 | 3 | NIH | 3/27/2025 | $551,943 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC020484 | Neural Mechanisms that Underlie Flexible Sensory Control of Behavioral States in C. elegans | 000 | 3 | NIH | 2/19/2025 | $342,445 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM144542 | Tools to determine and analyze the structures of molecular machines in motion | 000 | 4 | NIH | 2/19/2025 | $286,977 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD117580 | Understanding how experience shapes language development through comparisons of large language models and neural representations | 000 | 1 | NIH | 4/1/2025 | $74,284 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB035127 | An integrated toolkit for real-time analysis of coupled nascent transcription | 000 | 2 | NIH | 3/17/2025 | $381,084 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K00CA264312 | Cellular engineering to improve the efficacy and specificity of targeted immunotherapy | 000 | 4 | NIH | 4/1/2025 | $94,921 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG067151 | Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD | 000 | 5 | NIH | 3/13/2025 | $643,438 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH133066 | Neuron-astrocyte mechanisms of norepinephrine in goal-directed learning | 000 | 3 | NIH | 3/17/2025 | $550,982 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI126592 | Chemical Probes of Mycobacteria | 000 | 10 | NIH | 3/21/2025 | $579,261 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EY029666 | Neural Mechanisms for Feature-Based Attention | 002 | 7 | NIH | 3/13/2025 | $555,564 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD116425 | Developing a Biomimetic Lactating Mammary Lobe for Therapeutic Safety | 000 | 1 | NIH | 3/19/2025 | $76,756 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM039334 | Deciphering the Principles of Membrane-Associated Glycan Assembly for Glycoconjugate Biosynthesis | 000 | 36 | NIH | 2/17/2025 | $372,536 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM153091 | Developing Selective P-catalysts for Dehydrative Transformations | 000 | 2 | NIH | 1/9/2025 | $76,756 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB024261 | Expansion Microscopy | 000 | 8 | NIH | 1/8/2025 | $545,896 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HL178155 | Investigating the Role of Extracellular Matrix in Down Syndrome Associated Cardiac Phenotypes. | 001 | 1 | NIH | 12/20/2024 | $0 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH085802 | Early developmental mechanisms of Rett Syndrome | 000 | 15 | NIH | 2/13/2025 | $329,588 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC000238 | Experimental Theoretical Studies of Cochlear Mechanisms | 000 | 39 | NIH | 11/14/2024 | $331,691 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG069232 | Manipulating Neural Oscillations with Non-Invasive Sensory Stimulation for Alzheimer's Disease Intervention | 000 | 4 | NIH | 1/9/2025 | $622,402 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH131715 | Layer-specific manipulation to test feedforward/feedback cortical circuitry | 000 | 3 | NIH | 12/6/2024 | $246,666 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM144115 | Tissue morphogenesis: From signals to forces | 001 | 4 | NIH | 1/7/2025 | $489,141 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB031992 | SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A | 000 | 4 | NIH | 1/16/2025 | $544,206 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS119749 | A New Animal Model to Examine Nervous System Function Development and Regeneration | 000 | 5 | NIH | 1/15/2025 | $224,010 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U01NS121471 | Computational Neuroscience of Language Processing in the Human Brain | 000 | 5 | NIH | 1/15/2025 | $619,121 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL162564 | Nonviral delivery techniques for in vivo prime editing | 000 | 4 | NIH | 1/13/2025 | $387,750 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH126351 | Spatiotemporal dynamics of locus coeruleus circuits during learned behavior | 000 | 5 | NIH | 2/14/2025 | $371,228 |
| | 2025 | 2025 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HD110335 | Parsing the Interplay Between Biophysical and Biochemical Microenvironment Cues On Endometriosis Lesion Phenotypes Using Microphysiological Systems | 000 | 4 | NIH | 3/25/2025 | $323,667 |
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