| | | | | | | | | | | | | | | | |
| | |
 | Issue Date FY: 2026 ( Subtotal = $27,723,412 ) (Continued on the next page) |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DA062195 | Analyzing brain-wide bases of neuroplastic change using new imaging tools | 000 | 2 | NIH | 2/25/2026 | $603,959 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA235375 | Delivery of cytokines for cancer immunotherapy using nanolayer-controlled trafficking of liposomal nanoparticles | 000 | 7 | NIH | 1/9/2026 | $318,532 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA220468 | Bottlebrush polymer prodrugs for targeted delivery of combination therapies and in vivo imaging of pharmacological response | 001 | 9 | NIH | 4/16/2026 | $59,592 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA220468 | Bottlebrush polymer prodrugs for targeted delivery of combination therapies and in vivo imaging of pharmacological response | 000 | 9 | NIH | 12/16/2025 | $536,334 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI162307 | Investigation of Synthetic DNA-based Viral Particles for Spatially Controlled Antigen Presentation | 001 | 5 | NIH | 2/9/2026 | $844,182 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI126592 | Chemical Probes of Mycobacteria | 000 | 11 | NIH | 4/2/2026 | $579,261 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG081017 | Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV | 001 | 4 | NIH | 2/26/2026 | $73,611 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG081017 | Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV | 000 | 4 | NIH | 2/13/2026 | $662,498 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG087374 | Lipid imaging expansion microscopy to study Alzheimer's disease | 001 | 3 | NIH | 2/23/2026 | $77,114 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG087374 | Lipid imaging expansion microscopy to study Alzheimer's disease | 000 | 3 | NIH | 1/26/2026 | $694,036 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG082871 | Disparities in the Quality of Nursing Home Care | 000 | 4 | NIH | 4/17/2026 | $613,270 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS128717 | Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy | 001 | 3 | NIH | 3/4/2026 | $24,900 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS128717 | Developing Tools to Probe DnaJB6 Dynamics in Spinobulbular Muscular Atrophy | 000 | 3 | NIH | 12/15/2025 | $224,100 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG059661 | Tau structure and dynamics in Alzheimer's disease | 000 | 5 | NIH | 4/21/2026 | $414,575 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00CA286968 | Quantitative modeling of extrachromosomal DNA (ecDNA) evolution in tumors | 000 | 3 | NIH | 3/5/2026 | $248,618 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99DK146116 | Enhancing intestinal regeneration with Cysteine mediated dietary intervention | 000 | 1 | NIH | 3/19/2026 | $90,000 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K00CA284262 | Controlled Antigen Delivery for Prophylactic Cancer Vaccination | 000 | 4 | NIH | 4/3/2026 | $97,672 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K00CA253687 | Dissecting the molecular mechanisms of PRC2 dysregulation in cancer | 000 | 6 | NIH | 5/7/2026 | $100,563 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K00CA264312 | Cellular engineering to improve the efficacy and specificity of targeted immunotherapy | 000 | 5 | NIH | 4/2/2026 | $94,921 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31NS141336 | In Vivo Measurement of Human Brain Tissue, Blood, and CSF Dynamics Supporting Glymphatic Function | 001 | 2 | NIH | 3/31/2026 | $576 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31NS141336 | In Vivo Measurement of Human Brain Tissue, Blood, and CSF Dynamics Supporting Glymphatic Function | 000 | 2 | NIH | 2/19/2026 | $49,538 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD116425 | Developing a Biomimetic Lactating Mammary Lobe for Therapeutic Safety | 000 | 2 | NIH | 4/9/2026 | $81,580 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM154448 | Investigating mechanisms of coordinating actinstructure across multiple levels oforder | 002 | 2 | NIH | 2/6/2026 | $81,040 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM156282 | Drivers of adaptation and colonization within individual human microbiomes | 000 | 2 | NIH | 4/28/2026 | $524,900 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM157624 | Cationic Carbone-Boracycles as Far-Red and Near-Infrared Photoactive Agents | 000 | 2 | NIH | 12/17/2025 | $321,628 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM157324 | Biogeography of Microbial and Plant-Derived Redox-Active Small Molecules and Combinatorial Effects on Microbial Growth | 000 | 2 | NIH | 2/23/2026 | $393,718 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM156872 | Chemical Approaches to Understanding the Mechanisms of Iron-Sulfur Enzymes | 001 | 2 | NIH | 3/10/2026 | $56,445 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM158437 | Synthesis and Applications of Oligophosphate Constructs | 000 | 2 | NIH | 4/2/2026 | $402,867 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM124732 | Evolution and Regulation of Bacterial Proteome Composition | 000 | 9 | NIH | 2/17/2026 | $468,870 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM126982 | Metalloenzyme structure, function and assembly | 000 | 9 | NIH | 4/6/2026 | $410,347 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R33CA291166 | Advanced Development of Patient Ascites Therapeutic Response Biosensors | 000 | 2 | NIH | 4/17/2026 | $394,605 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21HL177773 | Emulated Target Trials of Steroids in Patients with Acute Respiratory Distress Syndrome | 000 | 2 | NIH | 2/11/2026 | $123,599 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R21AG099044 | Pilot of a new non-viral vector for therapeutic nucleic acid delivery to the CNS | 000 | 1 | NIH | 1/21/2026 | $466,340 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS141960 | Mechanisms of Network-Scale Neural Regeneration in a New Neuroscience Model | 000 | 2 | NIH | 5/7/2026 | $397,500 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS144823 | Spatially Multiplexed Imaging of Complex Signaling Networks | 000 | 1 | NIH | 5/5/2026 | $651,069 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS131457 | Brain-Wide Representations of Behavior During Aversive Internal States in C. Elegans | 000 | 4 | NIH | 2/19/2026 | $378,957 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS123120 | Non-Human Primate Model for Developing Closed-Loop Anesthesia Delivery Systems | 000 | 5 | NIH | 5/7/2026 | $362,374 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS121073 | Analysis of Integrated Brain Functions Using Hemogenetic Imaging | 000 | 5 | NIH | 2/19/2026 | $543,166 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH112694 | Simultaneous profiling of neuronal synapse activities, proteins, and messenger RNAs at the single-cell level | 000 | 7 | NIH | 1/15/2026 | $402,000 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH104536 | Imaging Synaptic Transmission of Individual Active Zones | 000 | 12 | NIH | 2/10/2026 | $397,500 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH131715 | Layer-specific manipulation to test feedforward/feedback cortical circuitry | 000 | 4 | NIH | 1/14/2026 | $286,798 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH133066 | Neuron-astrocyte mechanisms of norepinephrine in goal-directed learning | 000 | 4 | NIH | 2/24/2026 | $648,213 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH136275 | Neuron-Glial Interactions in Basal Ganglia Circuitry | 000 | 2 | NIH | 2/24/2026 | $652,879 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH060379 | Functional and anatomical characterization of the striosomal system | 000 | 25 | NIH | 1/21/2026 | $387,750 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL162564 | Nonviral delivery techniques for in vivo prime editing | 000 | 5 | NIH | 2/2/2026 | $387,750 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM144542 | Tools to determine and analyze the structures of molecular machines in motion | 001 | 5 | NIH | 3/25/2026 | $31,852 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM144542 | Tools to determine and analyze the structures of molecular machines in motion | 000 | 5 | NIH | 1/21/2026 | $286,669 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EY029666 | Neural Mechanisms for Feature-Based Attention | 000 | 8 | NIH | 1/9/2026 | $555,564 |
| | 2026 | 2026 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EY011289 | Novel Optical Diagnostics with Optical Coherence Tomography | 000 | 39 | NIH | 4/2/2026 | $645,024 |
|
