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Multi-morbidity in Uganda Research Capacity Initiative (MURCI) at Mbarara University of Science and Technology

Award Number: D43TW011632
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Multi-morbidity in Uganda Research Capacity Initiative (MURCI) at Mbarara University of Science and Technology - 1.0 Abstract Chronic, non-communicable diseases (NCDs) now account for over half of morbidity and reductions in quality of life, in resource-limited settings. Of particular importance is the growing epidemic of multi-morbidity, or the accumulation of chronic conditions, including combinations of both non-communicable (e.g. hypertension, diabetes, COPD, traumatic accidents, and cancer) and communicable diseases (e.g. HIV, prior lung disease from pneumonia) on functioning, well-being and quality of life. Despite the growing appreciation of overlapping conditions and their cumulative effect on health outcomes, the majority of disease treatment programs, donor funding mechanisms, and research infrastructures focus on infectious diseases, and such programs remain largely siloed. This separation of efforts results in three critical short-comings to the research infrastructure in many low-income settings: 1) a poor understanding and limited attention paid to the interactive effects between, and management of, comorbid conditions; 2) lack of attention to region-specific risk factors for multi- morbidity that are likely to differ from high-resource settings (e.g. social determinants of health, occupational exposures, air pollution); and 3) a near total absence of the requisite laboratory infrastructure for cross-cutting multidisciplinary clinical research to support holistic care for those with multi-morbid conditions. To respond to these gaps in research infrastructure in Uganda, we will conduct the following specific aims: Aim 1: Develop junior faculty expertise in Uganda on multi-morbidity. We will focus training on a holistic understanding of human health, and an understanding of how accumulation of chronic conditions impacts functioning and quality of life in this setting. Aim 2: Train junior faculty to measure determinants and consequences of the regional social and environmental risk factors for multi-morbidity. Key focus areas will include social-behavioral and environmental determinants of health. Aim 3: Develop laboratory capacity to support clinical research on multi-morbidity. We will leverage an established Memorandum of Understanding between the Massachusetts General Hospital (MGH) and the Mbarara University of Science and Technology (MUST) Clinical Research Laboratory to support capacity building, quality assurance, and a trans-disciplinary clinical laboratory program to focus on multi-morbidity diagnostics and regionally appropriate risk factor testing. In this D43 research training program, we will leverage a 15-year partnership between MUST and MGH, to provide sustained mentorship and protected research time to 12 promising post-doctoral and junior faculty members at MUST and establish a Ugandan regional center of excellence in multi-morbidity research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $244,807 )
2024	2024	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	PLOT 8-18 KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	5	5/15/2024	NON-COMPETING CONTINUATION	$244,807
														Subtotal = $244,807

Issue Date FY: 2023 ( Subtotal = $244,915 )
2023	2023	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	4	5/15/2023	NON-COMPETING CONTINUATION	$244,915
														Subtotal = $244,915

Issue Date FY: 2022 ( Subtotal = $244,655 )
2022	2022	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	3	6/7/2022	NON-COMPETING CONTINUATION	$244,655
														Subtotal = $244,655

Issue Date FY: 2021 ( Subtotal = $244,936 )
2021	2021	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	2	6/14/2021	NON-COMPETING CONTINUATION	$244,936
														Subtotal = $244,936

Issue Date FY: 2020 ( Subtotal = $246,731 )
2020	2020	MBARARA UNIVERSITY OF SCIENCE AND TECHNOLOGY	KABALE ROAD	MBARARA				UGA	International Research and Research Training	000	1	9/3/2020	NEW	$246,731
														Subtotal = $246,731

Grand Total All Awards = $1,226,044

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Multi-morbidity in Uganda Research Capacity Initiative (MURCI) at Mbarara University of Science and Technology

Award Number: D43TW011632

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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