Thursday, July 3, 2025 7/3/2025

HIV Clinical Pharmacology & Therapeutics Research Training Program

Award Number: D43TW010313
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2016
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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HIV Clinical Pharmacology & Therapeutics Research Training Program - This is a renewal application for a D43 titled, HIV Clinical Pharmacology and Therapeutics Research Training (HIVRT) program led by the University at Buffalo (UB) and the University of Zimbabwe (UZ). Optimizing HIV prevention of transmission with HIV PReP and treatment as prevention (TasP) to meet 95-95-95 and “ending the epidemic” strategies. However, successful use of these approaches requires that continued research be conducted to guide implementation in low-middle income countries. The HIVRT will increase the number of qualified investigators to seek external funding for this research effort. With the introduction of tenofovir, lamivudine and dolutegravir, long-acting ARVs (e.g., cabotegravir, rilpivirine), new ARVs (e.g., lenacapavir, islatravir) and HIV-1 broadly neutralizing antibodies (bNABs), clinical and translational research related to these new therapeutic agents is needed to examine the optimal pharmacokinetics-pharmacodynamics parameters that will prevent transmission and/or sustain viral load suppression as well as safety in the context of co-morbidities. Training of clinician-scientists and translational scientists will utilize the foundation that has been built by the prior UB-UZ HIVRT and transition to the newly designed research training program. Specific Aims: 1) Provide a HIVRT for pre-doctoral (5) and post-doctoral (5) trainees that increases the number of researchers with independent, funded programs with a focus on HIV clinical pharmacology and therapeutics and regional public health priorities including COVID-19, 2) Mentor HIVRT trainees in team science and that include others with expertise in pharmaceutical bioanalysis, biomedical informatics, data sciences, genomics, and microbiome, 3) Foster community support group engagement to participate in innovative research to study novel HIV clinical pharmacology and therapeutics strategies for prevention and treatment and investigate long-acting antiretrovirals and monoclonal antibodies and traditional medicines, and 4) Provide an HIVRT that fosters smart academic-public-private partnerships aimed at addressing sustainable developmental goals. Trainees will have intensive training at UB during which new knowledge and skills will allow formulation of a research project that will be conducted under continued supervision for 18 months at UZ for a total of two years of training. The program will build on our prior Fogarty International Center HIV Research Training program, and an earlier AITRP. These research training programs provide the foundation for this D43 renewal that includes an outstanding group of UZ and UB mentors who will provide mentoring and collaboration utilizing the HIV Clinical Pharmacology and Therapeutics foundation that has been built for HIV clinical and translational research. The curriculum will be organized and provided through an established Research and Education Training Core. The D43 has an outstanding external Training Advisory Committee that will contribute to a highly productive, efficient HIV Clinical Pharmacology and Therapeutics research training initiative in Zimbabwe.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $284,846 )
2025	2025	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	9	1/28/2025	NON-COMPETING CONTINUATION	$284,846
														Subtotal = $284,846

Issue Date FY: 2024 ( Subtotal = $287,733 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	8	1/15/2024	NON-COMPETING CONTINUATION	$287,733
														Subtotal = $287,733

Issue Date FY: 2023 ( Subtotal = $213,906 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	002	7	2/13/2023	NON-COMPETING CONTINUATION	$213,906
2023	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	001	6	12/9/2022	COMPETING CONTINUATION	$156,339
2023	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	5	12/9/2022	NON-COMPETING CONTINUATION	-$156,339
														Subtotal = $213,906

Issue Date FY: 2022 ( Subtotal = $281,953 )
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	001	6	3/31/2022	COMPETING CONTINUATION	$0
2022	2022	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	6	3/18/2022	COMPETING CONTINUATION	$281,953
														Subtotal = $281,953

Issue Date FY: 2020 ( Subtotal = $199,239 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	5	2/14/2020	NON-COMPETING CONTINUATION	$199,239
														Subtotal = $199,239

Issue Date FY: 2019 ( Subtotal = $524,942 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	4	3/7/2019	NON-COMPETING CONTINUATION	$293,451
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	001	4	8/9/2019	SUPPLEMENT FOR EXPANSION	$231,491
														Subtotal = $524,942

Issue Date FY: 2018 ( Subtotal = $360,409 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	3	2/26/2018	NON-COMPETING CONTINUATION	$360,409
														Subtotal = $360,409

Issue Date FY: 2017 ( Subtotal = $498,342 )
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	001	2	8/19/2017	SUPPLEMENT FOR EXPANSION	$145,446
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	004	2	9/13/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	002	2	9/8/2017	SUPPLEMENT FOR EXPANSION	$29,871
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	005	2	9/14/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	000	2	2/20/2017	NON-COMPETING CONTINUATION	$251,374
2017	2017	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	520 LEE ENTRANCE STE 211	AMHERST	NY	14228	ERIE	USA	International Research and Research Training	003	2	9/11/2017	SUPPLEMENT FOR EXPANSION	$71,651
														Subtotal = $498,342

Issue Date FY: 2016 ( Subtotal = $301,602 )
2016	2016	SUNY, BUFFALO	219 MARKLE HALL	BUFFALO	NY	10016		USA	International Research and Research Training	000	1	4/7/2016	NEW	$301,602
														Subtotal = $301,602

Grand Total All Awards = $2,952,972

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HIV Clinical Pharmacology & Therapeutics Research Training Program

Award Number: D43TW010313

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2016

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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