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Population Biology of African Malaria Vectors and Parasites

Award Number: D43TW001505
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/29/2000
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Population Biology of African Malaria Vectors and Parasites - Population Biology of African Malaria Vectors and Parasites Malaria is the most fatal vector-borne disease in Africa. At present, the first-line intervention tools are insecticide-treated nets and indoor residual spray that target indoor-biting mosquitoes. However, the spread of insecticide resistance and increasing outdoor biting behaviors of the malaria vectors has significantly hindered the effectiveness of these tools, resulting slow progress of malaria control in the past several years across Africa. In addition, the African continent has been experiencing very rapid environmental changes such as urbanization, deforestation, dam construction, irrigation and the resulting agricultural practice shift in the past two decades. On top of the vector behavioral change and insecticide resistance development, rapid environmental changes in the African continent have added additional challenges in malaria control. Addressing these challenges in malaria control requires knowledge on the impact of environmental modification on vector biology and epidemiology, and requires optimization of the vector control methods that are adaptive to the rapidly changing vector ecology and malaria epidemiology. Recent advancements in molecular biology, genomics, bioinformatics and ecological modeling, provide exciting opportunities for developing new malaria vector control tools and application strategies. Unfortunately, a large number of scientists from malaria-endemic countries have not been able to leverage these new technologies extensively in their research. The specific scientific objectives of this competing renewal application focus on mechanistic studies on the impact of environmental modifications on malaria vector biology, epidemiology, and development and evaluation of new malaria vector control tools and application strategies. The overarching goal of this program is to advance the career development of promising young scientists from sub-Saharan African countries and assist them address the new challenges in malaria vector control in their regions. We propose to accomplish this goal by training four postdoctoral fellows and eight Ph.D. students from malaria-endemic Africa, and through workshops and “training the trainers” sessions to broaden the impact of this program. In addition to obtaining research experience in molecular biology, bioinformatics, vector ecology and epidemiology, the program will offer a core training curriculum that focuses on biostatistics, bioinformatics, modeling, scientific writing and responsible conduct of research. The superb infrastructure and capacity at the international training sites in Kenya and Ethiopia and at the University of California at Irvine are ideal for the proposed training. This training program will contribute significantly to malaria research capacity building in Africa and career development of African scientists by bridging laboratory and field research experience in vector biology and malaria epidemiology, by equipping them with new technologies, by providing opportunities for them to develop valuable Africa-wide and international linkages, and empowering them to build and develop independent research capacity and projects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $298,080 )
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	001	26	7/23/2025	COMPETING CONTINUATION	$298,080
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	002	26	9/11/2025	COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	25	7/18/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $298,080

Issue Date FY: 2024 ( Subtotal = $298,080 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	001	25	9/6/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	25	11/15/2023	NON-COMPETING CONTINUATION	$298,080
														Subtotal = $298,080

Issue Date FY: 2023 ( Subtotal = $298,080 )
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	24	1/6/2023	NON-COMPETING CONTINUATION	$298,080
														Subtotal = $298,080

Issue Date FY: 2022 ( Subtotal = $298,080 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	000	23	12/20/2021	NON-COMPETING CONTINUATION	$298,080
														Subtotal = $298,080

Issue Date FY: 2021 ( Subtotal = $298,080 )
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	000	22	12/24/2020	NON-COMPETING CONTINUATION	$298,080
														Subtotal = $298,080

Issue Date FY: 2020 ( Subtotal = $300,080 )
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	001	21	4/6/2020	COMPETING CONTINUATION	$300,080
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	004	21	9/1/2020	COMPETING CONTINUATION	$9,060
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	002	21	4/27/2020	COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	000	20	4/5/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	003	20	9/1/2020	NON-COMPETING CONTINUATION	-$9,060
														Subtotal = $300,080

Issue Date FY: 2019 ( Subtotal = $270,000 )
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	000	20	2/13/2019	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $270,000

Issue Date FY: 2018 ( Subtotal = $270,000 )
2018	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	000	19	2/3/2018	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $270,000

Issue Date FY: 2017 ( Subtotal = $270,000 )
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	International Research and Research Training	000	18	1/28/2017	NON-COMPETING CONTINUATION	$270,000
														Subtotal = $270,000

Issue Date FY: 2016 ( Subtotal = $270,001 )
2016	2016	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	17	3/17/2016	NON-COMPETING CONTINUATION	$270,001
														Subtotal = $270,001

Issue Date FY: 2015 ( Subtotal = $272,000 )
2015	2015	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	16	5/7/2015	COMPETING CONTINUATION	$272,000
														Subtotal = $272,000

Issue Date FY: 2014 ( Subtotal = $192,758 )
2014	2014	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	15	6/9/2014	NON-COMPETING CONTINUATION	$192,758
														Subtotal = $192,758

Issue Date FY: 2013 ( Subtotal = $188,784 )
2013	2013	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	14	5/22/2013	NON-COMPETING CONTINUATION	$188,784
														Subtotal = $188,784

Issue Date FY: 2012 ( Subtotal = $198,720 )
2012	2012	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	13	6/6/2012	NON-COMPETING CONTINUATION	$198,720
														Subtotal = $198,720

Issue Date FY: 2011 ( Subtotal = $198,720 )
2011	2011	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	12	5/13/2011	NON-COMPETING CONTINUATION	$198,720
														Subtotal = $198,720

Issue Date FY: 2010 ( Subtotal = $198,720 )
2010	2010	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	11	7/9/2010	COMPETING CONTINUATION	$198,720
2010	2009	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	001	10	9/29/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $198,720

Issue Date FY: 2009 ( Subtotal = $133,950 )
2009	2009	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	10	3/25/2009	NON-COMPETING CONTINUATION	$133,950
														Subtotal = $133,950

Issue Date FY: 2008 ( Subtotal = $141,717 )
2008	2008	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	9	4/7/2008	NON-COMPETING CONTINUATION	$141,717
														Subtotal = $141,717

Issue Date FY: 2007 ( Subtotal = $133,593 )
2007	2007	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	8	4/11/2007	NON-COMPETING CONTINUATION	$133,593
														Subtotal = $133,593

Issue Date FY: 2006 ( Subtotal = $142,158 )
2006	2006	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	International Research and Research Training	000	7	3/24/2006	NON-COMPETING CONTINUATION	$142,158
														Subtotal = $142,158

Issue Date FY: 2005 ( Subtotal = $149,640 )
2005	2005	UNIVERSITY OF CALIFORNIA, IRVINE							International Research and Research Training	000	6	9/23/2005	COMPETING CONTINUATION	$149,640
														Subtotal = $149,640

Grand Total All Awards = $5,671,241

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Population Biology of African Malaria Vectors and Parasites

Award Number: D43TW001505

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/29/2000

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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