CTSA UM1 State University of New York at Buffalo - The University at Buffalo Clinical and Translational Science Institute (CTSI) and Buffalo Translational Consortium (BTC), the region’s leading academic, clinical and research institutions, with influential community partners has established genuine, enduring partnerships to implement translational science strategies to reduce health inequities and improve health in our community. Buffalo, NY, the second largest city in New York State (population 276,807), located in Erie County (population 950,683) has a diverse population (37% African American, 14% Latinx) and is one of the poorest cities in the US (31% in poverty). Our CTSI prioritizes people often excluded from clinical research and who experience health disparities, including racial and ethnic minorities, rural residents, LGBTQ+ communities, immigrants, and people with disabilities. The University at Buffalo CTSI has a vision to advance and accelerate clinical and translational science to reduce health disparities and improve health in our community and the nation. The CTSI has catalyzed a complete transformation of research in the region by overcoming clinical and translational science (CTS) barriers. Hub clinical trials have more than doubled since our CTSA was first funded in 2015 and our hub achieved our highest levels ever in participants enrolled in clinical research in 2023. Our recruitment team works tirelessly with hub researchers to increase enrollment of underrepresented minorities in clinical studies, reaching 24.2% this funding cycle, exceeding that of Erie County (20.8%), the population reach of our hub. The CTSI partnership with African American communities has enabled us to have a measurable impact in responding to health disparities and social determinants of health. We will build on this extraordinary momentum with bold, ambitious CTS initiatives with an overarching focus on health equity. We will develop and test new CTS tools in each module to improve the efficiency and effectiveness of clinical translation, engage community members in all phases of research, launch a new Dissemination & Implementation Core that will center the needs of the community, develop a novel curriculum to advance the role of community health workers on research teams, and many others. Our CTSI has five ambitious but achievable aims:1) Grow our enduring community partnerships and establish new partnerships to build trust, accelerate translation, and develop new approaches to reduce profound health disparities in our region. 2) Develop novel translational science methods to improve efficiency and effectiveness of clinical translation and work with other CTSA hubs to assess, adopt and share successful methods locally and nationally. 3) Inspire, train and mentor a multidisciplinary, diverse workforce in translational science, team science, data science, and implementation science with a focus on health equity to accelerate the translation of discoveries that will improve health in our region and the nation. And 4, innovate and disseminate novel informatics tools and methods to advance