Tuesday, July 1, 2025 7/1/2025

Advancing Cardiothoracic Surgical Trials in Rural Health Populations

Award Number: UM1HL147371
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/22/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Advancing Cardiothoracic Surgical Trials in Rural Health Populations - PROJECT SUMMARY The Cardiothoracic Surgical Trials Network (CTSN) has made significant contributions in advancing the evidence base for cardiothoracic surgery. As the population ages and the incidence of cardiovascular disease remains high, there is an important public health need to expand the capacity of the CTSN. Northern New England (NNE) is home to the most rural and elderly population in the US. Individuals living in NNE are medically underserved and face significant socioeconomic challenges. These conditions occur in the context of higher rates of comorbid conditions, leading to a high cardiovascular disease burden and lower life expectancy. Importantly, rural patients are underrepresented in cardiovascular clinical trials. As hospitals located in NNE, Dartmouth-Hitchcock Medical Center (DHMC) and Maine Medical Center (MMC) share a common goal of improving the health of rural communities. Specific aims are: (1) to expand the capacity of the CTSN in rural populations with high cardiovascular disease burden and develop strategies for implementing trial findings in such patients; (2) to support the development and clinical research capacity at MMC; and (3) to train the next generation of implementation science researchers through the Clinical and Implementation Research Skills Program (CIRSP). Several unique features of this collaboration will allow achievement of these aims. First, DHMC and MMC are the major referral centers for cardiac surgery in NNE, ensuring an ideal setting for recruiting patients with a high cardiovascular disease burden. Second, DHMC is an international leader in the use of regional and national registries to facilitate population-based research. DHMC is the data coordinating center for Northern New England Cardiovascular Disease Study Group (NNECDSG) which collects data on 90% of cardiac surgery in NNE. DHMC also maintains the largest non- federal repository of Medicare data in the US through the Dartmouth Atlas. Third, Dr. Iribarne has 11 years of experience with the CTSN and brings significant knowledge of lessons learned on optimal recruitment strategies for enrolling cardiac surgery patients. Fourth, DHMC and MMC have worked collaboratively in quality improvement since 1987 through the NNECDSG; the Linked Clinical Research Center (LCRC) program is a natural extension of this collaboration. Fifth, a group of nationally recognized experts in implementation science has been assembled to educate CIRSP Scholars in late-stage implementation research. The expected results are that: (1) the capacity of the CTSN will expand into rural populations with high cardiovascular disease burden; (2) implementation science will be integrated in future CTSN research; (3) MMC will be a leading enroller in CTSN trials; and (4) early career investigators will be trained in and perform late-stage implementation research using the CTSN infrastructure. These results will support the mission of the LCRC program in expanding the capacity of cardiothoracic surgery research in areas of need.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $470,622 )
2025	2025	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	001	7	2/26/2025	NON-COMPETING CONTINUATION	$470,622
2025	2024	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	000	6	1/23/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $470,622

Issue Date FY: 2024 ( Subtotal = $512,456 )
2024	2024	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	004	6	7/5/2024	NON-COMPETING CONTINUATION	$41,834
2024	2024	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	001	6	2/23/2024	NON-COMPETING CONTINUATION	$470,622
2024	2024	THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	003	6	6/13/2024	NON-COMPETING CONTINUATION	$0
2024	2023	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	002	5	3/6/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	000	5	11/14/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $512,456

Issue Date FY: 2023 ( Subtotal = $1,113,328 )
2023	2023	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	004	5	8/24/2023	SUPPLEMENT FOR EXPANSION	$556,664
2023	2023	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	001	5	4/2/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$556,664
2023	2023	FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, THE	350 COMMUNITY DR	MANHASSET	NY	11030	NASSAU	USA	Cardiovascular Diseases Research	003	5	7/13/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$240,666
2023	2022	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	000	4	4/1/2023	NON-COMPETING CONTINUATION	$0
2023	2022	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	002	4	7/13/2023	NON-COMPETING CONTINUATION	-$240,666
														Subtotal = $1,113,328

Issue Date FY: 2022 ( Subtotal = $559,654 )
2022	2022	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	002	4	6/20/2022	NON-COMPETING CONTINUATION	$55,968
2022	2022	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	000	4	4/3/2022	NON-COMPETING CONTINUATION	$503,686
2022	2021	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	001	3	4/30/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $559,654

Issue Date FY: 2021 ( Subtotal = $559,654 )
2021	2021	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	000	3	2/10/2021	NON-COMPETING CONTINUATION	$559,654
														Subtotal = $559,654

Issue Date FY: 2020 ( Subtotal = $559,654 )
2020	2020	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	000	2	3/13/2020	NON-COMPETING CONTINUATION	$559,654
2020	2019	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	001	1	3/16/2020	NEW	$0
														Subtotal = $559,654

Issue Date FY: 2019 ( Subtotal = $571,179 )
2019	2019	DARTMOUTH-HITCHCOCK CLINIC	ONE MEDICAL CENTER DR	LEBANON	NH	03756	GRAFTON	USA	Cardiovascular Diseases Research	000	1	3/21/2019	NEW	$571,179
														Subtotal = $571,179

Grand Total All Awards = $4,346,547

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Advancing Cardiothoracic Surgical Trials in Rural Health Populations

Award Number: UM1HL147371

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/22/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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