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Pediatric Brain Tumor Consortium A multi-institutional consortium devoted to novel phase I and II clinical evaluations of experimental treatment approaches for pediatric CNS tumors

Award Number: UM1CA081457
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/1999
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Pediatric Brain Tumor Consortium A multi-institutional consortium devoted to novel phase I and II clinical evaluations of experimental treatment approaches for pediatric CNS tumors - PBTC Project Summary/Abstract The primary goal of the Pediatric Brain Tumor Consortium (PBTC) is to rapidly and effectively contribute to the understanding and cure of pediatric central nervous system (CNS) tumors through innovative, multidisciplinary and multi-institutional prospective clinical trials. PBTC clinical trial development is not only based upon known prognostic factors but also upon an evolving understanding of pediatric brain tumor biology. The PBTC will continue to utilize innovative study designs and analyses based on state-of-the-art statistical science. Novel clinical trials will incorporate relevant correlative pharmacology, biology, neuroimaging, immunologic and genomics studies in an effort to define and integrate these modalities into a better understanding of pediatric CNS tumors. These goals will be accomplished through a close and continued partnership with the member institutions' basic and translational scientists as well as the clinical trial experts. In addition, the PBTC welcomes partnerships with investigators outside the consortium providing scientific, laboratory and regulatory support for innovative and high priority clinical trials. The PBTC will continue to maintain and grow its relationship with the National Cancer Institute (NCI) and its large network of adult and pediatric groups as well as with pharmaceutical and biotechnology companies. One of the most important goals of the PBTC is to successfully complete focused phase I and II clinical trials of novel agents and treatment approaches that can be then be translated into large prospective phase II and III studies overseen by the Children's Oncology Group (COG). The overarching long-term goal is to improve survival outcome and quality of life for children with CNS tumor diagnoses that so often lead to high morbidity and mortality such as diffuse intrinsic pontine gliomas, high-grade gliomas, infant embryonal tumors, refractory medulloblastoma, ependymoma, and low-grade gliomas. To this end, the PBTC will continue to focus upon introducing novel molecularly-targeted agents via innovative trials to assess the presence of the target in tumor and surrogate tissue, evaluate the ability of the agent to down-regulate its signaling target and better correlate pharmacokinetic and pharmacodynamic endpoints with toxicities and clinical responses. The PBTC will also continue to explore therapeutic opportunities for pediatric brain tumors through immunotherapeutic interventions as well as via local delivery of treatments. By focusing on the most common solid tumor in children which also accounts for the highest number of cancer-related deaths in pediatrics, the PBTC will continue to support the NCI's mission of helping all people live longer, healthier lives through its contributions to cancer research and identification of better treatments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,793,439 )
2025	2025	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	25	4/17/2025	SUPPLEMENT FOR EXPANSION	$3,793,439
														Subtotal = $3,793,439

Issue Date FY: 2024 ( Subtotal = $3,704,144 )
2024	2024	ST JUDE CHILDREN'S RESEARCH HOSPITAL INC	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	25	4/11/2024	NON-COMPETING CONTINUATION	$3,704,144
														Subtotal = $3,704,144

Issue Date FY: 2023 ( Subtotal = $3,361,716 )
2023	2023	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	24	3/30/2023	NON-COMPETING CONTINUATION	$3,361,716
														Subtotal = $3,361,716

Issue Date FY: 2022 ( Subtotal = $3,440,662 )
2022	2022	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	002	23	4/18/2022	NON-COMPETING CONTINUATION	$3,440,662
2022	2020	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	001	21	3/7/2022	COMPETING CONTINUATION	$18,592
2022	2019	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	20	3/7/2022	SUPPLEMENT FOR EXPANSION	-$18,592
														Subtotal = $3,440,662

Issue Date FY: 2021 ( Subtotal = $4,353,842 )
2021	2021	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	002	22	4/14/2021	NON-COMPETING CONTINUATION	$3,799,050
2021	2021	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	003	22	8/9/2021	NON-COMPETING CONTINUATION	$554,792
2021	2020	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	001	21	2/27/2021	COMPETING CONTINUATION	$50,260
2021	2019	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	20	2/27/2021	SUPPLEMENT FOR EXPANSION	-$50,260
														Subtotal = $4,353,842

Issue Date FY: 2020 ( Subtotal = $4,810,822 )
2020	2020	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	21	5/22/2020	COMPETING CONTINUATION	$4,395,266
2020	2020	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	003	21	9/23/2020	COMPETING CONTINUATION	$167,710
2020	2020	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	001	21	7/30/2020	COMPETING CONTINUATION	$415,556
2020	2019	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	002	20	9/23/2020	SUPPLEMENT FOR EXPANSION	-$167,710
														Subtotal = $4,810,822

Issue Date FY: 2019 ( Subtotal = $2,781,436 )
2019	2019	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	002	20	5/30/2019	SUPPLEMENT FOR EXPANSION	$2,781,436
2019	2018	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	001	20	5/14/2019	NON-COMPETING CONTINUATION	$0
2019	2018	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	20	12/10/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,781,436

Issue Date FY: 2018 ( Subtotal = $2,711,850 )
2018	2018	ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.	262 DANNY THOMAS PL	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	20	4/10/2018	NON-COMPETING CONTINUATION	$2,711,850
														Subtotal = $2,711,850

Issue Date FY: 2017 ( Subtotal = $2,728,300 )
2017	2017	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	262 DANNY THOMAS PL MAILSTOP # 509	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	001	19	6/8/2017	NON-COMPETING CONTINUATION	$272,830
2017	2017	ST. JUDE CHILDREN'S RESEARCH HOSPITAL	262 DANNY THOMAS PL MAILSTOP # 509	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	19	3/27/2017	NON-COMPETING CONTINUATION	$2,455,470
														Subtotal = $2,728,300

Issue Date FY: 2016 ( Subtotal = $2,711,401 )
2016	2016	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	18	3/30/2016	NON-COMPETING CONTINUATION	$2,711,401
														Subtotal = $2,711,401

Issue Date FY: 2015 ( Subtotal = $2,726,546 )
2015	2015	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	17	6/8/2015	NON-COMPETING CONTINUATION	$2,726,546
														Subtotal = $2,726,546

Issue Date FY: 2014 ( Subtotal = $2,825,454 )
2014	2014	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	000	16	6/23/2014	COMPETING CONTINUATION	$2,825,454
2014	2014	ST JUDE CHILDREN`S RESEARCH HOSPITAL	322 NORTH LAUDERDALE STREET	MEMPHIS	TN	38105	SHELBY	USA	Cancer Treatment Research	001	16	6/25/2014	COMPETING CONTINUATION	$0
														Subtotal = $2,825,454

Grand Total All Awards = $39,949,612

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Pediatric Brain Tumor Consortium A multi-institutional consortium devoted to novel phase I and II clinical evaluations of experimental treatment approaches for pediatric CNS tumors

Award Number: UM1CA081457

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/1999

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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