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Common Mechanisms linking Pre- and Post-Natal Exposures for Child Health Outcomes

Award Number: UH3OD023349
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Common Mechanisms linking Pre- and Post-Natal Exposures for Child Health Outcomes - Abstract The NIH Environmental influences on Child Health outcomes (ECHO) Program seeks to understand the impact of early environmental influences on child health and development – with a special emphasis on Pre-, Peri-, and Postnatal Health, Upper and Lower Airways, Neurodevelopment, Obesity, and Positive Health – and to enhance these areas of health and development. The Rochester-Magee award in the first phase of ECHO (UG3/UH3 OD023349) was a pregnancy cohort that followed children through age 4 years. In this proposal, which is responsive to RFA-OD-22-018 for the second phase of ECHO, we will recruit an additional pregnancy cohort of 375 pregnancies (across the first 5 years) and conduct a pediatric follow-up of our existing ECHO cohort (12601) and two Rochester-based ECHO cohorts that were part of other multi-site awards in first phase of ECHO: PROP/PRISM and TIDES-Rochester. Including these two additional cohorts in our pediatric follow- up plans increases the number of ECHO cohorts that are carried forward from the first to the second phase of ECHO and creates economies of scale and efficiencies for our pediatric follow-up. Collectively, we aim to follow 375 children across the three consolidated Rochester-based ECHO cohorts. In response to the RFA, we propose two areas of specialized outcomes, Neurodevelopment & Upper and Lower Airways/Asthma, and two areas of specialized exposures, Chemical exposure & Prenatal Immune Activation/Inflammation, that reflect expertise of the research team and measurement concentration and in- depth data related to the pregnancy and pediatric cohorts. Throughout the UG3 and UH3 phases of the second phase of the ECHO program we will institute practices to maximize retention of existing participants, ensure recruitment of diverse new pregnant/preconception participants, and implement the established ECHO Cohort Protocol with high fidelity. We will also lead novel and solution-oriented research that capitalizes on the data already on the ECHO platform and research that takes advantage of our specialized areas of expertise to understand how pre-conception, perinatal, and early postnatal exposures shape child health outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,645,546 )
2025	2025	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Trans-NIH Research Support	000	10	6/8/2025	EXTENSION WITH OR WITHOUT FUNDS	$1,645,546
														Subtotal = $1,645,546

Issue Date FY: 2024 ( Subtotal = -$52,513 )
2024	2022	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Trans-NIH Research Support	001	7	4/3/2024	NON-COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Trans-NIH Research Support	002	7	6/11/2024	NON-COMPETING CONTINUATION	$313,802
2024	2022	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Trans-NIH Research Support	003	7	6/21/2024	NON-COMPETING CONTINUATION	-$52,513
2024	2022	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Trans-NIH Research Support	000	7	4/2/2024	NON-COMPETING CONTINUATION	-$313,802
														Subtotal = -$52,513

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Trans-NIH Research Support	001	7	6/27/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	000	7	12/28/2022	NON-COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF ROCHESTER	910 GENESEE ST	ROCHESTER	NY	14611	MONROE	USA	Trans-NIH Research Support	002	6	6/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,437,800 )
2022	2022	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	000	7	8/26/2022	NON-COMPETING CONTINUATION	$2,437,800
														Subtotal = $2,437,800

Issue Date FY: 2021 ( Subtotal = $2,437,822 )
2021	2021	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	001	6	8/25/2021	NON-COMPETING CONTINUATION	$2,437,822
2021	2020	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	000	5	6/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,437,822

Issue Date FY: 2020 ( Subtotal = $2,437,822 )
2020	2020	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	001	5	8/14/2020	NON-COMPETING CONTINUATION	$2,437,822
2020	2019	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	002	4	8/24/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	000	4	3/13/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,437,822

Issue Date FY: 2019 ( Subtotal = $3,392,143 )
2019	2019	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	001	4	9/6/2019	NON-COMPETING CONTINUATION	$2,790,263
2019	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	000	3	2/8/2019	EXTENSION WITH OR WITHOUT FUNDS	$601,880
														Subtotal = $3,392,143

Issue Date FY: 2018 ( Subtotal = $2,440,263 )
2018	2018	UNIVERSITY OF ROCHESTER	500 JOSEPH C WILSON BLVD	ROCHESTER	NY	14627	MONROE	USA	Trans-NIH Research Support	000	3	8/29/2018	EXTENSION WITH OR WITHOUT FUNDS	$2,440,263
														Subtotal = $2,440,263

Grand Total All Awards = $14,738,883

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Common Mechanisms linking Pre- and Post-Natal Exposures for Child Health Outcomes

Award Number: UH3OD023349

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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