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Prevalence and predictors of opioid misuse after adolescent spinal fusion surgery

Award Number: UH3HD102038
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Prevalence and predictors of opioid misuse after adolescent spinal fusion surgery - Adolescents undergoing spinal fusion surgery experience severe acute postoperative pain and rely on opioids for pain relief. Neurobiological and psychosocial changes during adolescence increase vulnerability to chronic pain and to substance use, placing these youth at elevated risk for developing chronic postsurgical pain as well as persistent opioid use following surgery. Recent data suggest that 5-7% of adolescents prescribed an opioid after surgery develop subsequent persistent opioid use. However, there is a gap in understanding prevalence of opioid misuse and its associated risk factors following an opioid prescription after surgery in adolescents. Thus, opioids remain the cornerstone of acute moderate-severe pain management and are commonly prescribed to adolescents for pain following surgery. This study will explore opioid misuse in a large, well characterized, previously opioid-naive sample of adolescents enrolled in a randomized controlled trial testing a cognitive-behavioral intervention for reducing postoperative pain. The objective of this study is to prospectively collect data to characterize opioid misuse following surgery and identify risk factors for postoperative opioid misuse. Youth 12-18 years of age undergoing spinal fusion surgery will report on baseline anxiety, depression, and sleep, as well as lifetime misuse of prescription opioids, pain relief preferences, and pain relief expectancies. After surgery, youth will report on daily opioid use for 14 days following hospital discharge, and report on opioid misuse at 6-months post-surgery. The aims of this supplemental award are to 1) quantify the risk of postoperative opioid use, including opioid misuse patterns and reasons for opioid misuse, and 2) identify pre-surgery risk factors, as well as beliefs, and expectations before surgery associated with short-term daily opioid use and long-term opioid misuse following surgery. This study will identify prevalence and risk factors to inform future research in this area, and identify targets for perioperative intervention to reduce problematic opioid behaviors and resulting opioid use disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$4,462 )
2026	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	000	2	10/1/2025	SUPPLEMENT FOR EXPANSION	-$104
2026	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	001	2	10/1/2025	SUPPLEMENT FOR EXPANSION	-$4,358
														Subtotal = -$4,462

Issue Date FY: 2025 ( Subtotal = -$29,053 )
2025	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	000	2	10/1/2024	SUPPLEMENT FOR EXPANSION	-$29,053
														Subtotal = -$29,053

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	000	2	8/19/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	001	2	8/20/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	001	2	8/18/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	000	2	6/16/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $29,053 )
2021	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	000	2	12/22/2020	EXTENSION WITH OR WITHOUT FUNDS	$29,053
2021	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	002	2	9/10/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	001	2	3/8/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $29,053

Issue Date FY: 2020 ( Subtotal = $4,282,452 )
2020	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND PT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	000	2	9/18/2020	EXTENSION WITH OR WITHOUT FUNDS	$1,152,427
2020	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND PT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	001	2	9/21/2020	SUPPLEMENT FOR EXPANSION	$99,949
2020	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND PT WAY NE	SEATTLE	WA	98105	KING	USA	Child Health and Human Development Extramural Research	002	2	9/24/2020	EXTENSION WITH OR WITHOUT FUNDS	$3,030,076
														Subtotal = $4,282,452

Grand Total All Awards = $4,277,990

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Prevalence and predictors of opioid misuse after adolescent spinal fusion surgery

Award Number: UH3HD102038

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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