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 | Issue Date FY: 2025 ( Subtotal = $27,014,819 ) (Continued on the next page) |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R35GM139566 | Volatile Anesthetics and Metabolism | 001 | 5 | NIH | 2/20/2025 | $737,978 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI182006 | Targeting protein secretion in Mycobacterium tuberculosis | 000 | 2 | NIH | 12/27/2024 | $861,105 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI180452 | Transporter function of the Mycobacterium tuberculosis PE/PPE proteins | 000 | 2 | NIH | 12/3/2024 | $857,231 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | P01HD104435 | Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects | 000 | 5 | NIH | 12/18/2024 | $1,443,565 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI170914 | Functional exploration of a deep Mycobacterium tuberculosis phosphoproteome | 000 | 3 | NIH | 12/19/2024 | $575,240 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01MH135568 | Atypical Development in Infants and Toddlers: Computational Attentional Signatures through Mobile Eye Tracking | 000 | 2 | NIH | 11/22/2024 | $754,007 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 Sand Point Way NE | Seattle | WA | 98105-3916 | KING | USA | T2331575 | Children's Hospitals Graduate Medical Education Payment Program | 00 | 8 | HRSA | 12/9/2024 | $625,920 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 Sand Point Way NE | Seattle | WA | 98105-3916 | KING | USA | T2331575 | Children's Hospitals Graduate Medical Education Payment Program | 00 | 8 | HRSA | 12/9/2024 | $1,115,376 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K08AI166072 | Dissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granuloma | 000 | 4 | NIH | 12/12/2024 | $184,917 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K01AI187782 | Mechanisms of Innate Immune Activation in Mitochondrial Disease Onset and Progression | 000 | 1 | NIH | 12/11/2024 | $122,562 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI155536 | Structural Analysis and Inhibitor Optimization of Cryptosporidium n-myristoyltransferase for Drug Discovery | 000 | 5 | NIH | 11/6/2024 | $800,512 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01ES033785 | Assessing how Prenatal Phthalate Exposure Disrupts Placental Transcriptional Regulation and Contributes to Changes in Gestational Length | 001 | 3 | NIH | 10/30/2024 | $101,793 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01ES033785 | Assessing how Prenatal Phthalate Exposure Disrupts Placental Transcriptional Regulation and Contributes to Changes in Gestational Length | 000 | 3 | NIH | 10/29/2024 | $675,801 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R00CA263161 | Characterizing the role of MARCH5 in apoptosis regulation in acute myeloid leukemia | 000 | 4 | NIH | 3/14/2025 | $224,082 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21HD113971 | Presumptively Initiating Vaccines and Optimizing Talk for Inpatients (PIVOT-IN): A Vaccine Communication Training Intervention for Pediatric Inpatient Clinicians | 000 | 1 | NIH | 3/31/2025 | $220,000 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K99HL168211 | Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid Overdose | 000 | 2 | NIH | 3/31/2025 | $120,269 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R50CA275857 | Pediatric brain tumors: Improving survival through integration of clinical molecular diagnostics and biologically targeted therapies into clinical trials | 000 | 3 | NIH | 3/13/2025 | $175,338 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01DK136980 | Interrogating The Biology Of Human Lupus Nephritis Using Single Cell Resolution Spatial Transcriptomics | 000 | 2 | NIH | 3/28/2025 | $742,873 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K01DA058543 | Dissociating respiratory depression and analgesia via a data-driven model of interacting respiratory and pain networks | 000 | 3 | NIH | 3/20/2025 | $101,477 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AR075813 | Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE | 000 | 5 | NIH | 1/9/2025 | $482,898 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI188789 | Species-transcending prevention of mosquito vector infection | 000 | 1 | NIH | 11/14/2024 | $832,071 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01HL163103 | Hexosamine biosynthesis pathway metabolism during cardiac hypertrophy | 000 | 3 | NIH | 11/13/2024 | $735,425 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R03NS135446 | Brain Tumor CAR T Mouse Model | 000 | 2 | NIH | 1/29/2025 | $98,450 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | U01AI165455 | Collective Responses to Malaria Vaccination | 000 | 4 | NIH | 1/16/2025 | $679,001 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI172824 | Parasite and host cell factors involved in the formation and persistence of Plasmodium vivax hypnozoites | 000 | 3 | NIH | 1/16/2025 | $742,943 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R21CA280139 | Identifying non-cardiotoxic drug combinations for patients with relapsed sarcoma | 000 | 2 | NIH | 1/15/2025 | $207,115 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01DE032663 | Influence of viral and immune interventions on early events following oral SIV infection | 000 | 3 | NIH | 1/15/2025 | $717,601 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI158536 | Uncovering the parasite and host determinants of Plasmodium vivax hypnozoite formation and development using single cell sequencing and human liver-chimeric mice | 000 | 4 | NIH | 1/6/2025 | $761,655 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AR076978 | Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies | 000 | 5 | NIH | 12/20/2024 | $490,752 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI183642 | Targeted vaccines against pulmonary NTM infections in vulnerable populations | 000 | 1 | NIH | 12/20/2024 | $950,092 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | U01AI155335 | Biologically informed design of CD8+ T cell-dependent pre-erythrocytic stage malaria vaccines | 000 | 5 | NIH | 12/20/2024 | $1,204,933 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01HL166317 | Unraveling a parabrachial circuit for the state-dependent control of rapid breathing | 000 | 3 | NIH | 11/26/2024 | $797,260 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01HD111410 | Development of a Multiplex Proteomics Assay for High-Throughput Newborn Screening of a New Set of Treatable Neonatal Diseases | 000 | 3 | NIH | 2/12/2025 | $437,165 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01MH123442 | Advancing Suicide Intervention Strategies for Teens During High Risk Periods | 000 | 4 | NIH | 1/27/2025 | $1,021,649 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K99AI182458 | Elucidating a novel respiratory-mammary axis of T cell immunity | 000 | 1 | NIH | 12/16/2024 | $114,976 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI163160 | Dysregulated asthmatic epithelial interferon responses to viruses drive exacerbation, T2 inflammation, and airway remodeling | 000 | 4 | NIH | 1/23/2025 | $838,670 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R25NS141155 | Summer Undergraduate Program to Advance Research and Equity in Pain and Neurological Health | 000 | 1 | NIH | 12/3/2024 | $129,113 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01MH113545 | Investigating the synaptic pathology of Autism | 000 | 8 | NIH | 1/3/2025 | $661,502 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K24AR085177 | Mentoring the next generation of researchers in pediatric autoimmunity | 000 | 1 | NIH | 1/19/2025 | $212,574 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R33HS029399 | Inform Shared Decision-making with Advanced Bayesian Causal Inference to Improve Quality of Pediatric Rheumatology Care | 000 | 3 | AHRQ | 3/25/2025 | $259,672 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01EY033364 | Optimizing Models of Non-Coding Genetic Risk in Age-Related Macular Degeneration | 000 | 4 | NIH | 2/14/2025 | $492,250 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AG081840 | Pericyte control of capillary perfusion in the Alzheimer's disease brain | 000 | 3 | NIH | 2/14/2025 | $759,334 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21CA280726 | Designing inducible chemotactic beacons for enhanced trafficking of CAR T cells to solid tumors | 000 | 2 | NIH | 3/24/2025 | $248,537 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R37CA266777 | The IL-18-IFNγ axis predicts response to immunotherapy | 000 | 3 | NIH | 2/14/2025 | $717,404 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HD106628 | Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling | 000 | 4 | NIH | 2/18/2025 | $693,654 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01MH108519 | Regulation of mTOR signaling in the developing cerebral cortex as a point of convergence for multiple autism risk factors | 002 | 11 | NIH | 3/5/2025 | $415,863 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K01MD019730 | Youth climate activism on social media: Building psychosocial resilienceamong minority youth | 004 | 3 | NIH | 2/18/2025 | $114,633 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI177257 | Perturbations of host cell signaling by a complex hepatotropic pathogen | 000 | 13 | NIH | 2/13/2025 | $663,183 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R00NS112575 | Dissecting the Action Learning Process with Dopaminergic Reinforcement | 000 | 4 | NIH | 2/20/2025 | $224,094 |
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