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 | Issue Date FY: 2025 ( Subtotal = $69,232,687 ) (Continued on the next page) |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R37CA289981 | B7-H3 CAR T cells following initial radiation for children and young adults with diffuse intrinsic pontine glioma | 000 | 1 | NIH | 5/26/2025 | $456,414 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01EY033364 | Optimizing Models of Non-Coding Genetic Risk in Age-Related Macular Degeneration | 000 | 4 | NIH | 2/14/2025 | $492,250 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HD103700 | Brain Injury Outpatient Education and Care Navigation | 000 | 5 | NIH | 4/21/2025 | $589,533 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21HD118297 | Use of Oscillometry for the Evaluation of Pulmonary Function Following Pediatric Acute Respiratory Failure. | 000 | 1 | NIH | 4/24/2025 | $224,083 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AI165351 | Rapid disease progression and viral reservoir formation in SIV-infected infant macaques | 000 | 5 | NIH | 5/21/2025 | $871,114 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | S10OD038341 | Seattle Children's Shared Light Sheet Microscopy Facility | 000 | 1 | NIH | 4/3/2025 | $450,173 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HL144801 | Unraveling the dynamic mechanisms underlying opioid respiratory depression | 000 | 5 | NIH | 6/5/2025 | $972,132 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21HD113971 | Presumptively Initiating Vaccines and Optimizing Talk for Inpatients (PIVOT-IN): A Vaccine Communication Training Intervention for Pediatric Inpatient Clinicians | 000 | 1 | NIH | 3/31/2025 | $220,000 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AI132819 | Mechanisms of T Cell Quiescence and Exhaustion | 003 | 6 | NIH | 4/17/2025 | $645,962 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01ES025169 | TIDES III: Endocrine Disruption, Hormones, and Sex Differences in Adolescent Airway Health | 000 | 9 | NIH | 5/30/2025 | $1,331,982 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K08HS029028 | Using telehealth to improve access to gender-affirming care for BIPOC and rural gender diverse youth | 000 | 3 | AHRQ | 4/23/2025 | $143,057 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HL126523 | Unraveling respiratory rhythm generation in medullary and supramedullary networks | 000 | 10 | NIH | 4/17/2025 | $858,264 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | T32HD007233 | Academic Pediatric Infectious Disease | 000 | 43 | NIH | 5/7/2025 | $382,388 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K24AR085177 | Mentoring the next generation of researchers in pediatric autoimmunity | 000 | 1 | NIH | 1/19/2025 | $212,574 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01DK136980 | Interrogating The Biology Of Human Lupus Nephritis Using Single Cell Resolution Spatial Transcriptomics | 001 | 2 | NIH | 5/21/2025 | $82,542 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21AI182872 | A Structure-based orthology approach to predict protein function in eukaryotic parasites | 000 | 2 | NIH | 4/25/2025 | $244,625 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01DK136980 | Interrogating The Biology Of Human Lupus Nephritis Using Single Cell Resolution Spatial Transcriptomics | 000 | 2 | NIH | 3/28/2025 | $742,873 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AR075813 | Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE | 002 | 5 | NIH | 6/4/2025 | $37,560 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01NS117434 | Endotelin-1 role in development and regeneration | 003 | 6 | NIH | 6/19/2025 | $615,241 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01MD015723 | The Family Bridge Program to Address Communication and Navigation-Related Inequities for Minority Children and Families: A Randomized Controlled Trial | 001 | 4 | NIH | 4/17/2025 | $779,022 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01MH108519 | Regulation of mTOR signaling in the developing cerebral cortex as a point of convergence for multiple autism risk factors | 002 | 11 | NIH | 3/5/2025 | $415,863 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HD106628 | Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling | 000 | 4 | NIH | 2/18/2025 | $693,654 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HD106628 | Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling | 001 | 4 | NIH | 4/16/2025 | $77,073 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01NS143924 | Modeling mTOR network dynamics to achieve optimal drug rescue of congenital mTORopathies | 000 | 1 | NIH | 6/26/2025 | $754,066 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K23HD100566 | Clinical factors associated with long-term recovery following pediatric critical illness and injury | 002 | 5 | NIH | 4/10/2025 | $155,736 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | U01DA060443 | Deep Analysis of Transcriptome to Understand the Genetics of Substance Use Disorders in Rats | 000 | 1 | NIH | 6/27/2025 | $944,888 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AG081840 | Pericyte control of capillary perfusion in the Alzheimer's disease brain | 000 | 3 | NIH | 2/14/2025 | $759,334 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI155536 | Structural Analysis and Inhibitor Optimization of Cryptosporidium n-myristoyltransferase for Drug Discovery | 000 | 5 | NIH | 11/6/2024 | $800,512 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI163160 | Dysregulated asthmatic epithelial interferon responses to viruses drive exacerbation, T2 inflammation, and airway remodeling | 000 | 4 | NIH | 1/23/2025 | $838,670 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K08DK138302 | Epigenetic regulation of kidney regeneration | 000 | 2 | NIH | 5/29/2025 | $154,980 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R35GM139566 | Volatile Anesthetics and Metabolism | 001 | 5 | NIH | 2/20/2025 | $737,978 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI158536 | Uncovering the parasite and host determinants of Plasmodium vivax hypnozoite formation and development using single cell sequencing and human liver-chimeric mice | 000 | 4 | NIH | 1/6/2025 | $761,655 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K08AI166072 | Dissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granuloma | 000 | 4 | NIH | 12/12/2024 | $184,917 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01HL163103 | Hexosamine biosynthesis pathway metabolism during cardiac hypertrophy | 000 | 3 | NIH | 11/13/2024 | $735,425 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HS029142 | Development and Evaluation of an Instrument to Measure Shared Decision-Making in Pediatrics | 000 | 3 | AHRQ | 6/6/2025 | $386,987 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI182006 | Targeting protein secretion in Mycobacterium tuberculosis | 000 | 2 | NIH | 12/27/2024 | $861,105 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | P01HD104435 | Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects | 001 | 5 | NIH | 4/15/2025 | $160,393 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | P01HD104435 | Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects | 000 | 5 | NIH | 12/18/2024 | $1,443,565 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | UM1DA058220 | 'Mosaicism in Human Tissues, from Telomere to Telomere to RFA-22-013: "Somatic Mosaicism across Human Tissues Program: Genome Characterization Centers." | 001 | 3 | NIH | 6/20/2025 | $2,999,999 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21CA280139 | Identifying non-cardiotoxic drug combinations for patients with relapsed sarcoma | 001 | 2 | NIH | 6/3/2025 | $23,012 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R21CA280139 | Identifying non-cardiotoxic drug combinations for patients with relapsed sarcoma | 000 | 2 | NIH | 1/15/2025 | $207,115 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K99HL168211 | Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid Overdose | 001 | 2 | NIH | 5/15/2025 | $0 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K99HL168211 | Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid Overdose | 000 | 2 | NIH | 3/31/2025 | $120,269 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AI181218 | Immunotherapeutic approach for the prevention of secondary infection with drug-resistant TB | 000 | 2 | NIH | 4/28/2025 | $978,349 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R03AI180586 | Cross development of surrogate efficacy mycobacterial growth inhibition assay endpoint for the translational guinea pig model | 000 | 2 | NIH | 4/25/2025 | $97,850 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AR076978 | Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies | 001 | 5 | NIH | 4/30/2025 | $38,170 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AR076978 | Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies | 000 | 5 | NIH | 12/20/2024 | $490,752 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01DE032663 | Influence of viral and immune interventions on early events following oral SIV infection | 001 | 3 | NIH | 5/5/2025 | $79,732 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01DE032663 | Influence of viral and immune interventions on early events following oral SIV infection | 000 | 3 | NIH | 1/15/2025 | $717,601 |
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