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 | Issue Date FY: 2025 ( Subtotal = $48,416,453 ) (Continued on the next page) |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21HD118297 | Use of Oscillometry for the Evaluation of Pulmonary Function Following Pediatric Acute Respiratory Failure. | 000 | 1 | NIH | 4/24/2025 | $224,083 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | S10OD038341 | Seattle Children's Shared Light Sheet Microscopy Facility | 000 | 1 | NIH | 4/3/2025 | $450,173 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AI132819 | Mechanisms of T Cell Quiescence and Exhaustion | 003 | 6 | NIH | 4/17/2025 | $645,962 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21HD113971 | Presumptively Initiating Vaccines and Optimizing Talk for Inpatients (PIVOT-IN): A Vaccine Communication Training Intervention for Pediatric Inpatient Clinicians | 000 | 1 | NIH | 3/31/2025 | $220,000 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K08HS029028 | Using telehealth to improve access to gender-affirming care for BIPOC and rural gender diverse youth | 000 | 3 | AHRQ | 4/23/2025 | $143,057 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HD106628 | Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling | 000 | 4 | NIH | 2/18/2025 | $693,654 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HD106628 | Supraphysiologic Shear Stresses Associated with Cardiopulmonary Bypass are Sufficient to Activate RIKP3 Signaling | 001 | 4 | NIH | 4/16/2025 | $77,073 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HL126523 | Unraveling respiratory rhythm generation in medullary and supramedullary networks | 000 | 10 | NIH | 4/17/2025 | $858,264 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AR075813 | Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE | 000 | 5 | NIH | 1/9/2025 | $482,898 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K24AR085177 | Mentoring the next generation of researchers in pediatric autoimmunity | 000 | 1 | NIH | 1/19/2025 | $212,574 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01DK136980 | Interrogating The Biology Of Human Lupus Nephritis Using Single Cell Resolution Spatial Transcriptomics | 000 | 2 | NIH | 3/28/2025 | $742,873 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R21AI182872 | A Structure-based orthology approach to predict protein function in eukaryotic parasites | 000 | 2 | NIH | 4/25/2025 | $244,625 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI172824 | Parasite and host cell factors involved in the formation and persistence of Plasmodium vivax hypnozoites | 000 | 3 | NIH | 1/16/2025 | $742,943 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI183642 | Targeted vaccines against pulmonary NTM infections in vulnerable populations | 000 | 1 | NIH | 12/20/2024 | $950,092 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R33HS029399 | Inform Shared Decision-making with Advanced Bayesian Causal Inference to Improve Quality of Pediatric Rheumatology Care | 000 | 3 | AHRQ | 3/25/2025 | $259,672 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01MH113545 | Investigating the synaptic pathology of Autism | 000 | 8 | NIH | 1/3/2025 | $661,502 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01HL170607 | Mechanisms by which red blood cells contribute cardiopulmonary bypass associated inflammation | 000 | 2 | NIH | 4/3/2025 | $753,324 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K99AI182458 | Elucidating a novel respiratory-mammary axis of T cell immunity | 000 | 1 | NIH | 12/16/2024 | $114,976 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K01AI187782 | Mechanisms of Innate Immune Activation in Mitochondrial Disease Onset and Progression | 000 | 1 | NIH | 12/11/2024 | $122,562 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01DA048036 | Molecular genetic mechanisms of opioid receptor signaling | 003 | 8 | NIH | 4/18/2025 | $776,335 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI180452 | Transporter function of the Mycobacterium tuberculosis PE/PPE proteins | 000 | 2 | NIH | 12/3/2024 | $857,231 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R25NS141155 | Summer Undergraduate Program to Advance Research and Equity in Pain and Neurological Health | 000 | 1 | NIH | 12/3/2024 | $129,113 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01HL166317 | Unraveling a parabrachial circuit for the state-dependent control of rapid breathing | 000 | 3 | NIH | 11/26/2024 | $797,260 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K23HD103872 | Improving Diversity in Neonatal Clinical Trial Enrollment | 000 | 5 | NIH | 4/7/2025 | $159,764 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01MH135568 | Atypical Development in Infants and Toddlers: Computational Attentional Signatures through Mobile Eye Tracking | 000 | 2 | NIH | 11/22/2024 | $754,007 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K23HD100566 | Clinical factors associated with long-term recovery following pediatric critical illness and injury | 002 | 5 | NIH | 4/10/2025 | $155,736 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI188789 | Species-transcending prevention of mosquito vector infection | 000 | 1 | NIH | 11/14/2024 | $832,071 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01HD111410 | Development of a Multiplex Proteomics Assay for High-Throughput Newborn Screening of a New Set of Treatable Neonatal Diseases | 000 | 3 | NIH | 2/12/2025 | $437,165 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R00CA263161 | Characterizing the role of MARCH5 in apoptosis regulation in acute myeloid leukemia | 000 | 4 | NIH | 3/14/2025 | $224,082 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R37CA266777 | The IL-18-IFNγ axis predicts response to immunotherapy | 000 | 3 | NIH | 2/14/2025 | $717,404 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AI014102 | Mitochondrial DNA of Normal and Mutant Trypanosomes | 001 | 48 | NIH | 4/25/2025 | $1,158,683 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K01DA058543 | Dissociating respiratory depression and analgesia via a data-driven model of interacting respiratory and pain networks | 000 | 3 | NIH | 3/20/2025 | $101,477 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R35GM139566 | Volatile Anesthetics and Metabolism | 001 | 5 | NIH | 2/20/2025 | $737,978 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | K08AI166072 | Dissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granuloma | 000 | 4 | NIH | 12/12/2024 | $184,917 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI158536 | Uncovering the parasite and host determinants of Plasmodium vivax hypnozoite formation and development using single cell sequencing and human liver-chimeric mice | 000 | 4 | NIH | 1/6/2025 | $761,655 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01HL163103 | Hexosamine biosynthesis pathway metabolism during cardiac hypertrophy | 000 | 3 | NIH | 11/13/2024 | $735,425 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AI182006 | Targeting protein secretion in Mycobacterium tuberculosis | 000 | 2 | NIH | 12/27/2024 | $861,105 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | P01HD104435 | Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects | 001 | 5 | NIH | 4/15/2025 | $160,393 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | P01HD104435 | Utilization of Advanced Technologies for the Understanding of Human Structural Birth Defects | 000 | 5 | NIH | 12/18/2024 | $1,443,565 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R21CA280139 | Identifying non-cardiotoxic drug combinations for patients with relapsed sarcoma | 000 | 2 | NIH | 1/15/2025 | $207,115 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AI181218 | Immunotherapeutic approach for the prevention of secondary infection with drug-resistant TB | 000 | 2 | NIH | 4/28/2025 | $978,349 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | K99HL168211 | Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid Overdose | 000 | 2 | NIH | 3/31/2025 | $120,269 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01AR076978 | Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies | 001 | 5 | NIH | 4/30/2025 | $38,170 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01AR076978 | Three-model platform for understanding DMD epigenetic mechanisms and advancing small molecule therapies | 000 | 5 | NIH | 12/20/2024 | $490,752 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R01DE032663 | Influence of viral and immune interventions on early events following oral SIV infection | 001 | 3 | NIH | 5/5/2025 | $79,732 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | R01DE032663 | Influence of viral and immune interventions on early events following oral SIV infection | 000 | 3 | NIH | 1/15/2025 | $717,601 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3916 | KING | USA | U01AI155335 | Biologically informed design of CD8+ T cell-dependent pre-erythrocytic stage malaria vaccines | 000 | 5 | NIH | 12/20/2024 | $1,204,933 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | R03AI180586 | Cross development of surrogate efficacy mycobacterial growth inhibition assay endpoint for the translational guinea pig model | 000 | 2 | NIH | 4/25/2025 | $97,850 |
| | 2025 | 2025 | SEATTLE CHILDREN'S HOSPITAL | 4800 SAND POINT WAY NE | SEATTLE | WA | 98105-3901 | KING | USA | U54AI170855 | Behavior of HIV in Viral Environments (B-HIVE) | 001 | 4 | NIH | 4/28/2025 | $5,862,824 |
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