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Development of an Oral Analgesic for Neuropathic Pain

Award Number: UH2NS094258
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/20/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2017

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Development of an Oral Analgesic for Neuropathic Pain - ¿ DESCRIPTION (provided by applicant): Project Summary/Abstract Chronic pain is a debilitating health condition that is currently insufficiently treated by available therapies. Ther is a growing need to develop alternatives to treat chronic pain and specifically diabetic neuropathy as diabetes is increasing worldwide and painful neuropathy occurs in 50% of diabetic patients. Recently, the importance of lipids as signaling mediators and their functional significance in nociception has been elucidated. Epoxy-fatty acid metabolites generated by cytochrome P450s mediate analgesia, and we have synthesized small molecule inhibitors of their metabolizing enzyme, the soluble epoxide hydrolase (sEH), to elevate their levels in vivo. With this proposal, we aim to develop a novel and safe oral inhibitor of sEH for the treatment of peripheral neuropathy in diabetic patients. Preclinical studies with our candidate, EC5026, demonstrate efficacy that exceeds current therapies for diabetic neuropathy. Based on efficacy, good PK/ADME properties and stability, EicOsis has selected EC5026 to enter further development stages. EicOsis will work with Blueprint Development Teams to create a development plan and initiate studies to test the safety of EC5026 in Phase 1 clinical trials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$3,187 )
2019	2016	EICOSIS, LLC	25242 COUNTY ROAD 95	DAVIS	CA	95616	YOLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/4/2019	SUPPLEMENT FOR EXPANSION	-$3,187
														Subtotal = -$3,187

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	5/3/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2016	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	5/4/2017	NEW	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $274,162 )
2016	2016	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/15/2015	NEW	$224,163
2016	2016	EICOSIS, LLC	1407 NUTMEG LN	DAVIS	CA	95618	YOLO	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	7/15/2016	SUPPLEMENT FOR EXPANSION	$49,999
														Subtotal = $274,162

Grand Total All Awards = $270,975

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Development of an Oral Analgesic for Neuropathic Pain

Award Number: UH2NS094258

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/20/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2017

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